Results 21 to 30 of about 5,689,156 (145)

Updates on the Evaluation of Lupus Arthritis [PDF]

Rheumatology and Therapy
Lupus arthritis is the most common manifestation of systemic lupus erythematosus (SLE), affecting up to 95% of patients. Clinical presentations range from inflammatory arthralgia and non-deforming non-erosive (NDNE) synovitis to Jaccoud arthropathy and ...
Wei Tang, Alberto Nordmann-Gomes, Leila Khalili, Giovanna Rosas, Ellen Montgomery, Laurel Zhang, Stephen Suh, Robert Clancy, Anca D. Askanase   +8 more
doaj   +2 more sources

Evaluation of anti-citrullinated and anti-carbamylated antibodies in mexicans with rheumatoid arthritis and at-risk individuals [PDF]

Revista de Investigación Clínica
Background: Rheumatoid arthritis (RA) diagnosis is a challenge in the initial phases of the disease when clinical symptoms are only starting to develop.
Edgar E. Lara-Ramírez, Betzaida Cuevas-Córdoba, Diana Olguín-Calderon, Yadira Bastian, César Ramos-Remus, José D. Castillo-Ortiz, Martín Zapata-Zúñiga, Jesús Núñez-Contreras, Leendert A. Trouw, José A. Enciso-Moreno, Julio E. Castañeda-Delgado   +10 more
doaj   +2 more sources

Anti-Modified Peptide Antibodies (AMPAs) in Rheumatoid Arthritis: Study of the Diagnostic Value of Citrullinated, Homocitrullinated, and Acetylated Fibrin/Filaggrin Chimeric Peptides [PDF]

Diagnostics
Background/Objectives. The presence of anti-citrullinated peptide/protein antibodies (ACPAs), anti-carbamylated peptide/protein antibodies (anti-CarPs), and anti-acetylated peptide/protein antibodies (AAPAs), collectively termed as anti-modified peptide ...
Isabel Haro, Raul Castellanos-Moreira, Raimon Sanmartí, María José Gómara   +3 more
doaj   +2 more sources

Anti-Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap-Mediated Bone Loss in Rheumatoid Arthritis. [PDF]

Arthritis Rheumatol
Objective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Nakabo S, Hanata N, Patino-Martinez E, Holewinski R, Barrera-Vargas A, Merayo-Chalico J, Coonrod SA, Fox DA, Kaplan MJ, Carmona-Rivera C.   +9 more
europepmc   +2 more sources

Anti-carbamylated protein antibodies in ACCP-negative and ACCP-positive patients with rheumatoid arthritis [PDF]

Научно-практическая ревматология
Objective. Assess the level of antibodies to carbamylated proteins (anti-CarP) and analyse the clinical and immunological associations in patients with ACCP-negative and ACCP-positive variants of rheumatoid arthritis.Materials and methods.
D. A. Dibrov, A. S. Avdeeva, M. E. Diatroptov, E. L. Nasonov   +3 more
doaj   +2 more sources

Anti-Modified Protein Antibodies in Rheumatoid Arthritis: Pathogenic, Protective, or Passive Bystander? [PDF]

Immunol Rev
ABSTRACT The presence of anti‐modified protein antibodies (AMPA) is a hallmark of rheumatoid arthritis (RA). AMPA recognize post‐translationally modified proteins and are cross‐reactive. AMPA include anti‐citrullinated protein antibodies (ACPA), anti‐carbamylated protein antibodies (anti‐CarP), and anti‐acetylated protein antibodies (AAPA).
Stalman AFL, van der Woude D.
europepmc   +2 more sources

Complement Activation by Post-Translationally Modified Proteins: Links to Chronic Inflammation and Autoimmunity. [PDF]

Immunol Rev
ABSTRACT Post‐translational modifications (PTMs) of proteins are essential to maintain homeostasis as many cellular processes rely on reversible PTMs. However, several PTMs, particularly irreversible PTMs in the extracellular space, can contribute to tissue dysfunction, inflammation, and may even trigger the development of autoimmunity against PTM ...
van Greevenbroek MMJ, Trouw LA.
europepmc   +2 more sources

Research progress on anti-carbamylated protein antibodies in connective tissue disease [PDF]

Xin yixue, 2023
Connective tissue disease （CTD） is a group of chronic autoimmune diseases characterized by pathological changes in systemic organs and multisystems. The diagnosis of CTD mainly depends on clinical manifestations and specific autoantibodies.
Dong Rongrong, Yang Qingrui, Ma Zhenzhen
doaj   +1 more source

Low mortality rate in Italian rheumatoid arthritis patients from a tertiary center: putative implication of a low anti-carbamylated protein antibodies prevalence [PDF]

Open Access Rheumatology: Research and Reviews, 2018
Daniela Iacono,1 Elvira Favoino,2 Alessia Borgia,1 Serena Fasano,1 Ilenia Pantano,1 Virginia D’Abrosca,1 Giuseppe Picillo,1 Rosa Daniela Grembiale,3 Federico Perosa,2 Gabriele Valentini1 1Department of Clinical and Experimental Medicine ...
Iacono D, Favoino E, Borgia A, Fasano S, Pantano I, D'Abrosca V, Picillo G, Grembiale RD, Perosa F, Valentini G   +9 more
doaj   +2 more sources

Protective and Pathogenic Antibodies to Citrullinated Antigens. [PDF]

Immunol Rev
ABSTRACT Autoimmune diseases start years before clinical onset. In rheumatoid arthritis (RA), autoantibodies to citrullinated proteins (ACPA) and to modified IgG (rheumatoid factors, RF) can be detected many years before the inflammatory attack on cartilaginous joints. It has been assumed that these antibodies are pathogenic.
Sareila O, He Y, Xu Z, Ge C, Lönnblom E, Holmdahl R.   +5 more
europepmc   +2 more sources