Results 31 to 40 of about 5,689,156 (145)

Rheumatoid arthritis and the proinflammatory cytokine IL-17 [PDF]

Folia Medica, 2023
Introduction: Rheumatoid arthritis (RA) is the most common inflammatory joint disease. Various proinflammatory cytokines are involved in the pathogenesis of this chronic disorder.
Pavel Selimov, Rositsa Karalilova, Ljubinka Damjanovska, Ginka Delcheva, Teodora Stankova, Katya Stefanova, Ana Maneva, Teodor Selimov, Anastas Batalov   +8 more
doaj   +3 more sources

Detection and clinical significance of anti-carbamylated protein antibody in serologically negative patients with rheumatoid arthritis [PDF]

Xin yixue, 2022
Objective To probe into the level and clinical significance of anti-carbamylated protein （CarP） antibody in serologically negative patients with rheumatoid arthritis （RA）.
Wu Tao, Chen Chutao, Yang Lijuan, Zou Yaowei, Ma Jianda, Xu Yanhui, Jia Lei, Dai Lie
doaj   +1 more source

The value of anti-CarP and anti-PAD4 as markers of rheumatoid arthritis in ACPA/RF negative rheumatoid arthritis patients

Therapeutic Advances in Musculoskeletal Disease, 2021
Background: Anti-citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF) are key factors in the American College of Rheumatology/European League Against Rheumatism rheumatoid arthritis (RA) classification criteria markers.
Bogdan Kolarz, Marek Ciesla, Ann K. Rosenthal, Magdalena Dryglewska, Maria Majdan   +4 more
doaj   +1 more source

Evidence of Site-Specific Mucosal Autoantibody Secretion in Rheumatoid Arthritis. [PDF]

Arthritis Rheumatol
Objective Anti–citrullinated protein antibodies (ACPA) have been detected in sputum and saliva, indicating that anti–modified protein antibodies (AMPA) can be produced at mucosal sites in patients with rheumatoid arthritis (RA). However, the body's largest mucosal compartment, the gut, has not yet been examined.
Derksen VFAM, Martinsson K, van Mourik AG, Wagenaar CA, Toes REM, Walrabenstein W, Sjöberg D, van Schaardenburg D, Huizinga TWJ, Kastbom A, Svärd A, van der Woude D.   +11 more
europepmc   +2 more sources

Rheumatoid Arthritis Diagnostic and Monitoring Testing Patterns by Physicians and Advanced Practice Providers in the United States, 2012 to 2024. [PDF]

ACR Open Rheumatol
Objective To investigate longitudinal trends in rheumatoid arthritis (RA) diagnosis and monitoring by physicians and advanced practice providers (APPs) as measured by laboratory testing. Methods We conducted a retrospective review of RA‐associated diagnostic and monitoring tests ordered through Labcorp by 7,026 physicians and 2,188 APPs in primary care
Lee MK, Lee K, Alfego D, Naides SJ.
europepmc   +2 more sources

Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

Immunity, Inflammation and Disease, Volume 11, Issue 12, December 2023., 2023
Abstract Background Autoimmune diseases (AD) are severe pathophysiological ailments that are stimulated by an exaggerated immunogenic response towards self‐antigens, which can cause systemic or site‐specific organ damage. An array of complex genetic and epigenetic facets majorly contributes to the progression of AD, thus providing significant insight ...
Sagnik Nag, Oishi Mitra, Garima Tripathi, Souvik Samanta, Bikramjit Bhattacharya, Priti Chandane, Sourav Mohanto, Vino Sundararajan, Sumira Malik, Sarvesh Rustagi, Suraj Adhikari, Aroop Mohanty, Darwin A. León‐Figueroa, Alfonso J. Rodriguez‐Morales, Joshuan J. Barboza, Ranjit Sah   +15 more
wiley   +1 more source

Long noncoding RNA00324 is involved in the inflammation of rheumatoid arthritis by targeting miR‐10a‐5p via the NF‐κB pathway

Immunity, Inflammation and Disease, Volume 11, Issue 6, June 2023., 2023
Linc00324 is significantly increased in peripheral blood mononuclear cells of rheumatoid arthritis (RA). Linc00324 is preferentially expressed in CD4+ T cells, and promots CD4+ T cells proliferation and MIP‐1α secretion. Linc00324 may contribute to RA pathogenesis through NF‐κB signaling by targeting miR‐10a‐5p.
Binbin Xie, Faquan Lin, Wei Bao, Yangyang Zhang, Yi Liu, Xiaohui Li, Wei Hou, Qiyan Zeng   +7 more
wiley   +1 more source

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

MedComm, Volume 4, Issue 3, June 2023., 2023
The reversible and irreversible protein posttranslational modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, SUMOylation, and redox modifications, are essential regulators in organisms and cells. This work systematically summarizes the features, regulatory mechanisms, substrates, functions, and related ...
Qian Zhong, Xina Xiao, Yijie Qiu, Zhiqiang Xu, Chunyu Chen, Baochen Chong, Xinjun Zhao, Shan Hai, Shuangqing Li, Zhenmei An, Lunzhi Dai   +10 more
wiley   +1 more source

Unique Serum Immune Phenotypes and Stratification of Oklahoma Native American Rheumatic Disease Patients

Arthritis Care &Research, Volume 75, Issue 4, Page 936-946, April 2023., 2023
Objective Native American (NA) populations have higher rates of rheumatic disease and present with overlapping disease symptoms and nontraditional serologic features, thus presenting an urgent need for better biomarkers in NA diagnostics. This study used a machine learning approach to identify immune signatures that more effectively stratify NA ...
Samantha Slight‐Webb, Carla J. Guthridge, Joseph Kheir, Hua Chen, Ly Tran, Tim Gross, Virginia Roberts, Sohail Khan, Michael Peercy, Bobby Saunkeah, Joel M. Guthridge, Judith A. James   +11 more
wiley   +1 more source

Peripheral Blood Biomarkers for Rheumatoid Arthritis–Associated Interstitial Lung Disease: A Systematic Review

ACR Open Rheumatology, Volume 5, Issue 4, Page 201-226, April 2023., 2023
Background Biomarkers have been proposed as tools to aid in the identification and prognostication of interstitial lung disease (ILD) in rheumatoid arthritis (RA). We performed a systematic review of studies evaluating peripheral blood biomarkers and their association with RA‐ILD and its prognosis.
Daniel Van Kalsbeek, Rebecca Brooks, Dawson Shaver, Ariadne Ebel, Daniel Hershberger, Cynthia Schmidt, Jill A. Poole, Dana P. Ascherman, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England   +10 more
wiley   +1 more source