Results 21 to 30 of about 10,780 (181)

The isotype and IgG subclass distribution of anti-carbamylated protein antibodies in rheumatoid arthritis patients

Arthritis Research & Therapy, 2017
Background Anti-carbamylated protein (anti-CarP) antibodies have recently been reported to occur in around 45% of rheumatoid arthritis (RA) patients and to have prognostic and diagnostic properties.
Myrthe A. M. van Delft, Marije K. Verheul, Leonie E. Burgers, Veerle F. A. M. Derksen, Annette H. M. van der Helm-van Mil, Diane van der Woude, Tom W. J. Huizinga, René E. M. Toes, Leendert A. Trouw   +8 more
doaj   +1 more source

Antibodies specific for carbamylated proteins precede the onset of clinical symptoms in mice with collagen induced arthritis. [PDF]

PLoS ONE, 2014
ObjectiveThe immune response to post-translationally modified antigens is a key characteristic of rheumatoid arthritis. Carbamylation is such a posttranslational modification.
Jeroen N Stoop, Bi-Sheng Liu, Jing Shi, Diahann T S L Jansen, Martin Hegen, Tom W J Huizinga, Leendert A Trouw, René E M Toes   +7 more
doaj   +1 more source

Antibodies against multiple post-translationally modified proteins aid in diagnosis of autoimmune hepatitis and associate with complete biochemical response to treatment

Frontiers in Medicine, 2023
Background(Auto)immune mediated and cholestatic liver disease (AILD) includes autoimmune hepatitis (AIH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC).
Michelle D. van den Beukel, Anna E. C. Stoelinga, Adriaan J. van der Meer, Stef van der Meulen, Lu Zhang, Maarten E. Tushuizen, Bart van Hoek, Leendert A. Trouw   +7 more
doaj   +1 more source

Anti-Carbamylated Fibrinogen Antibodies Might Be Associated With a Specific Rheumatoid Phenotype and Include a Subset Recognizing In Vivo Epitopes of Its γ Chain One of Which Is Not Cross Reactive With Anti-Citrullinated Protein Antibodies

Frontiers in Immunology, 2021
To identify the targets recognized by anti-carbamylated protein antibodies (anti-CarP) in patients with early Rheumatoid Arthritis (RA), to study the cross-reactivity between anti-CarP and anti-citrullinated protein antibodies (ACPA) and to evaluate ...
Pauline Brevet, Pauline Brevet, Claire Lattard, Claire Lattard, Clément Guillou, Pascal Rottenberg, Patrice Fardellone, Xavier Le-Loët, Thierry Lequerré, Thierry Lequerré, Pascal Cosette, Olivier Boyer, Olivier Boyer, Manuel Fréret, Manuel Fréret, Olivier Vittecoq, Olivier Vittecoq   +16 more
doaj   +1 more source

Anti-Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap-Mediated Bone Loss in Rheumatoid Arthritis. [PDF]

Arthritis Rheumatol
Objective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Nakabo S, Hanata N, Patino-Martinez E, Holewinski R, Barrera-Vargas A, Merayo-Chalico J, Coonrod SA, Fox DA, Kaplan MJ, Carmona-Rivera C.   +9 more
europepmc   +2 more sources

Acquirement of HRP conjunct IgG anti-IgMs from most widely cultured freshwater fishes in China and its immunoreactivity

Anais da Academia Brasileira de Ciências, 2021
Until now, custom-made or commercial polyclonal antibody against only one kind of fish IgM limited application of the antibody. During our research on development of vaccine against infection of Clonorchis sinensis (C. sinensis) in several kinds of fish,
XINYI ZHOU, HONGYE JIANG, ZELI TANG, HENGCHANG SUN, ZHIPENG LIN, QING BIAN, GUANQUN YAO, TIANYOU ZHANG, MEICHENG CHEN, WEIWEI ZENG, XINBING YU, YAN HUANG   +11 more
doaj   +1 more source

Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis

Arthritis Research & Therapy, 2017
Background Rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibodies are rheumatoid arthritis (RA)-associated autoantibodies. Besides their presence in human serum, anti-CarP antibodies have
Marije K. Verheul, Michel P. M. Vierboom, Bert A. ’t Hart, Rene E. M. Toes, Leendert A. Trouw   +4 more
doaj   +1 more source

Added value of multiple autoantibody testing for predicting progression to inflammatory arthritis in at-risk individuals

RMD Open, 2022
Background Predicting progression to clinical arthritis in individuals at-risk of developing rheumatoid arthritis is a prerequisite to developing stratification groups for prevention strategies. Selecting accurate predictive criteria is the critical step
Paul Emery, K Mankia, Laurence Duquenne, Farag Shuweihdi, L A Trouw, Frederique Ponchel, Diane Corscadden, Xuanxiao Xie   +7 more
doaj   +1 more source

Meta-Analysis: Diagnostic Accuracy of Anti-Carbamylated Protein Antibody for Rheumatoid Arthritis. [PDF]

PLoS ONE, 2016
The anti-carbamylated protein (CarP) antibody is a novel biomarker that might help in the diagnosis of rheumatoid arthritis (RA). We aim to assess the diagnostic value of anti-CarP antibody for RA.We systematically searched PubMed, Embase, the Cochrane ...
Liubing Li, Chuiwen Deng, Si Chen, Shulan Zhang, Ziyan Wu, Chaojun Hu, Fengchun Zhang, Yongzhe Li   +7 more
doaj   +1 more source

FRI0040 Characterization of anti-carbamylated synovial protein antibodies (ANTI-CARPS) in rheumatoid arthritis patients [PDF]

Annals of the Rheumatic Diseases, 2017
Background Anti-carbamylated protein antibodies (anti-CarP) are a new type of autoantibodies specific of patients with RA. Reactivity has generally been tested with in vitro carbamylated proteins from fetal calf serum (FCS) as anti-CarPF. It is likely that other sources of antigens could be more suitable than FCS unless the reactivity of the ...
C Regueiro, A Montes, MD Boveda, S Amhaz-Escanlar, E Perez-Pampin, A Mera-Varela, A Gonzalez   +6 more
openaire   +1 more source