Results 171 to 180 of about 11,963 (190)

Identification of carbamylated alpha 1 anti-trypsin (A1AT) as an antigenic target of anti-CarP antibodies in patients with rheumatoid arthritis

Journal of Autoimmunity, 2017
In 2011 a novel autoantibody system, anti-carbamylated protein (anti-CarP) antibodies, was described in rheumatoid arthritis (RA) patients. Anti-CarP antibody positivity associates with a more severe disease course, is observed years before disease onset, and may predict the development of RA in arthralgia patients.
Verheul, Marije K.; Yee, Alvin; Seaman, Andrea; Janssen, George M.; van Veelen, Peter A.; Drijfhout, Jan W.; Toes, Rene E. M.; Mahler, Michael; Trouw, Leendert A.   +9 more
openaire   +3 more sources

The differentiation of germ cells and gonads during development of carp (Cyprinus carpio L.). A study with anti-carp sperm monoclonal antibodies

Development, 1985
ABSTRACT Gonadal development, germ cell differentiation and the appearance of membrane antigenic determinants, specific for male and female germ cells during gonadogenesis, was studied in larval and juvenile carp (Cyprinus carpio L.) until 25 weeks after fertilization.
Parmentier, H.K., Timmermans, L.P.M.
openaire   +3 more sources

The association between anti-carbamylated protein (anti-CarP) antibodies and radiographic progression in early rheumatoid arthritis: a study exploring replication and the added value to ACPA and rheumatoid factor

Annals of the Rheumatic Diseases, 2017
Anti-carbamylated protein (anti-CarP) antibodies are reported to associate with more radiographic progression within the total rheumatoid arthritis (RA) population and anti-citrullinated peptide antibody (ACPA)-negative subgroup. We explored the association of anti-CarP with radiographic progression in RA and aimed to replicate the association and ...
Ajeganova, S.; van Steenbergen, H. W.; Verheul, M. K.; Forslind, K.; Hafstrom, I.; Toes, R. E. M.; Huizinga, T. W. J.; Svensson, B.; Trouw, L. A.; van der Helm-van Mil, A. H. M.   +10 more
openaire   +4 more sources

AB0259 Anti-Carbamylated Protein (ANTI-CARP) Antibodies Are Present in the Sera of Individuals at Different Stages of the Inflammatory Arthritis Continuum

Annals of the Rheumatic Diseases, 2014
Background In inflammatory arthritis (IA) the spectrum varies from individuals “at-risk” to the full rheumatoid arthritis phenotype. ACPA are highly specific for RA and associated with severe progression. Recently, anti-carbamylated protein (anti-CarP) antibodies have been identified in the sera of individuals with RA and prior to diagnosis, predicting
L. Hunt, M. Verheul, J.L. Nam, L. Trouw, M. Fechtenbaum, C. Rakieh, E.M. Hensor, R. Toes, M.H. Buch, P. Emery   +9 more
openaire   +1 more source

A1.28 Anti-carp antibodies in two large cohorts of patients with rheumatoid arthritis and their relationship to genetic risk factors and smoking

Annals of the Rheumatic Diseases, 2014
Background and Objectives In rheumatoid arthritis (RA), the presence of antibodies to citrullinated proteins (ACPA) is strongly associated with certain genetic risk factors and smoking. The recently identified antibodies against carbamylated proteins (anti-CarP) are present in part of ACPA-positive, but also ACPA-negative RA patients.
Xia Jiang, Leendert A Trouw, Tineke J van Wesemael, Jing Shi, Henrik Källberg, Vivi Malmström, Lena Israelsson, Hulda Hreggvidsdottir, Willem Verduijn, Lars Klareskog, Lars Alfredsson, Tom W J Huizinga, Rene E M Toes, Karin Lundberg, Diane van der Woude   +14 more
openaire   +1 more source

Ontogeny of the immune system in carp (Cyprinus carpio L.) the appearance of antigenic determinants on lymphoid cells detected by mouse anti-carp thymocyte monoclonal antibodies

Developmental & Comparative Immunology, 1983
Mouse anti-carp thymocyte monoclonal antibodies were used to investigate the appearance of lymphoid cell determinants in young carp. Determinants detected by clone WCT 4 were present on thymocytes as soon as the thymus was visible histologically, day 4 after fertilization (a.f.) at 21 degrees C, but WCT 4-positive lymphocytes were not present in the ...
C J, Secombes, J J, van Groningen, W B, van Muiswinkel, E, Egberts   +3 more
openaire   +2 more sources

Phenotypic changes in germ cells during gonadal development of the common carp (Cyprinus carpio)

Histochemistry, 1992
A procedure is described in which large early spermatogonia were isolated from carp testes and purified from an initial 4-5% recovery up to 60-70% using equilibrium density centrifugation on a continuous Percoll gradient. Mice were immunized with the spermatogonia via the intrasplenic route. Six hybridoma cultures, producing monoclonal antibodies (MAbs)
van Winkoop, A., Timmermans, L.P.M.
openaire   +3 more sources

FRI0013 Anti-Carbamylated Protein Antibodies (ANTI-CARP) Precede the Onset of Rheumatoid Arthritis

Annals of the Rheumatic Diseases, 2014
J. Shi, L. van de Stadt, N. Levarht, T. Huizinga, D. Hamann, D. van Schaardenburg, R. Toes, L. Trouw   +7 more
openaire   +1 more source

POS0463 ASSOCIATION OF CIRCULATING LEVELS OF ANTI-CARP ANTIBODIES WITH DISEASE ACTIVITY AND RADIOLOGICAL DAMAGE IN RHEUMATOID ARTHRITIS PATIENTS

Annals of the Rheumatic Diseases, 2023
M. Markovic, C. Campochiaro, B. Glisic, M. Petronijevic, G. Ristic, I. Stanojevic, D. Vojvodic, N. Viapiana, M. Matucci-Cerinic, L. Dagna   +9 more
openaire   +1 more source

THU0031 Anti-Carbamylated Protein Antibodies (Anti-CarP) Precede the Onset of Rheumatoid Arthritis

Annals of the Rheumatic Diseases, 2013
J. Shi, L. van de Stadt, N. Levarht, T. Huizinga, D. Hamann, D. van Schaardenburg, R. Toes, L. Trouw   +7 more
openaire   +1 more source