Results 211 to 220 of about 68,398 (251)
Some of the next articles are maybe not open access.
Mechanisms of killing by anti-CD20 monoclonal antibodies
Molecular Immunology, 2007CD20 is a cell-surface marker expressed on mature B cells and most malignant B cells, but not stem or plasma cells. It is an ideal target for monoclonal antibodies (mAb), such as rituximab and ofatumumab, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following mAb ...
Glennie, Martin J. +3 more
openaire +3 more sources
Anti-CD20 monoclonal antibodies in multiple sclerosis
Expert Review of Neurotherapeutics, 2016The therapeutic utility of the anti-CD20 monoclonal antibodies (mAbs) is currently being evaluated in multiple sclerosis (MS) in line with the better understanding of the role of B lymphocytes in MS pathogenesis. Area covered: We conducted a literature search using Medline/Pub Med database of basic research and available controlled trials about anti ...
Irene, Moreno Torres +1 more
openaire +2 more sources
Treatment of SLE with Anti-CD20 Monoclonal Antibody
2004Systemic lupus erythemaotsus (SLE) is an autoimmune disease involving multiple organ systems and characterized by anti-nuclear antibodies. While T cells and dendritic cells may play major roles in SLE, several lines of evidence strongly suggest a central role for B cells.
R John, Looney +2 more
openaire +2 more sources
Anti‐CD20 monoclonal antibody therapy in multiple myeloma
British Journal of Haematology, 2008SummaryCD20 is a particularly appealing target that is expressed on the surface of almost all B cells, with no significant shedding, secretion or internalization. In contrast to the demonstrated efficacy of anti‐CD20 strategies in various B‐cell lymphoproliferative disorders, the role of such therapy in multiple myeloma is undetermined and ...
Prashant, Kapoor +5 more
openaire +2 more sources
Anti-CD20 monoclonal antibodies: Beyond B-cells
Blood Reviews, 2013Anti-CD20 monoclonal antibodies (MoAbs), employed in treating CD20⁺ lymphomas and autoimmune diseases, appear to have broader functions than just eradicating malignant B-cells and decreasing autoantibody production. Rituximab-induced T-cell inactivation, reported both in-vitro and in-vivo, may contribute to the increased risk of T-cell-dependent ...
Irit, Avivi +2 more
openaire +2 more sources
Anti-CD20 monoclonal antibodies in chronic lymphocytic leukemia
Expert Opinion on Biological Therapy, 2012The last decade has witnesd immense progress in the treatment of chronic lymphocytic leukemia (CLL). Chemoimmunotherapy (CIT) combining rituximab and fludarabine with cyclophosphamide (FCR) in the frontline setting has clearly been shown to improve outcomes in patients with CLL.
Preetesh, Jain, Susan, O'Brien
openaire +2 more sources
Anti-CD20 Monoclonal Antibodies for Relapsing and Progressive Multiple Sclerosis
CNS Drugs, 2020Multiple sclerosis (MS) was previously thought to be a T-cell-mediated, demyelinating disease of the central nervous system. Disease-modifying therapies targeting T cells have, indeed, shown remarkable efficacy in patients with relapsing-remitting MS.
Finn Sellebjerg +2 more
openaire +3 more sources
Treatment of Refractory Pemphigus with the Anti-CD20 Monoclonal Antibody (Rituximab)
Dermatology, 2007<i>Background:</i> Pemphigus is a severe blistering disorder caused by autoantibodies to desmogleins 1 and 3. Because some patients with pemphigus never enter into remission, new immunosuppressants are warranted. Rituximab is a chimeric monoclonal antibody binding to the CD20 antigen on B cells, which proved to be effective in recalcitrant ...
A.V. Marzano +4 more
openaire +2 more sources
The use of rituximab, anti‐CD20 monoclonal antibody, in pediatric transplantation
Pediatric Transplantation, 2004Abstract: Rituximab, chimeric anti‐human CD20, is approved for treatment of B‐cell lymphoma in adults. It is being used experimentally in other various immune related disease such as immune thrombocytopenic purpura, myasthenia gravis, and rheumatoid arthritis.
openaire +2 more sources