Structure and molecular interaction analysis of monoclonal antibodies in complex with receptor tyrosine kinases [PDF]
, 2010 Misregulated receptor tyrosine kinases (RTKs), i.e. the epidermal growth factor receptor EGFR or the insulin-like growth factor receptor 1 (IGF-1R), can be involved in the development of cancer.
Schmiedel, Judith
core
Comparison of Tissue Preparations to Identify and Phenotype T Cells in Human Colorectal Tumor Tissue
Cytometry Part A, EarlyView.ABSTRACT Archived patient samples (e.g., formalin‐fixed paraffin embedded (FFPE) tissue blocks, cryoembedded tissue blocks, and frozen whole tissue samples) are a source of immune information for which corresponding patient data is often collected.
Justin F. Tirados +5 more
wiley +1 more source
Frontiers in MedicinePurposeThis study aimed to assess the effectiveness of anti-CD20 monoclonal antibody and hetrombopag for relapsed/refractory immune thrombocytopenia (ITP) following glucocorticoid treatment.MethodsWe retrospectively included four patients with relapsed ...
Xiaolei Zhang +6 more
doaj +1 more source
New anti-CD20 monoclonal antibodies: which is the best? [PDF]
Leukemia & Lymphoma, 2014 Rituximab (MabTh era â , Rituxan â ), a chimeric immunoglobulin G1 (IgG1) monoclonal antibody (Mab) targeting CD20, has dramatically improved the outcome of most B-cell lymphoproliferative disorders. Regarding the clinical effi cacy of this Mab, little is known however on how rituximab works in vivo , and it is speculated that rituximab induces both Fv-
Anne-Laure, Gagez, Guillaume, Cartron
openaire +2 more sources
Combinatorial functions of two chimeric antibodies directed to human CD4 and one directed to the a-chain of the human interleukin-2 receptor [PDF]
, 1992 The general feasibility of chimerization of monoclonal antibodies (mAbs) has already been shown for a large number of them. In order to evaluate in vitro parameters relevant to immunosuppressive therapy, we have chimerized and synthesized two anti-CD4 ...
Schwirzke, Marina +10 more
core +1 more source
Targeted treatment for chronic lymphocytic leukemia: clinical potential of obinutuzumab
Pharmacogenomics and Personalized Medicine, 2014 Lukáš Smolej 4th Department of Internal Medicine – Hematology, University Hospital Hradec Králové and Charles University in Prague, Faculty of Medicine in Hradec Králové, Hradec Králové, Czech
Smolej L
doaj
Cytometry Part B: Clinical Cytometry, EarlyView.Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley +1 more source
The Development and Evaluation of Novel Reagents for Pre-Targeted Radioimmunotherapy [PDF]
, 2004 PhDIn a pretargeting radioimmunotherapy system, monoclonal antibodies (MAbs) derivatised with a high affinity streptavidin receptor are used in a localisation step.
Hainsworth, James Edward Scott
core
Mass-Production and Characterization of Anti-CD20 Monoclonal Antibody in Peritoneum of Balb/c Mice [PDF]
, 2013 Purpose: Monoclonal antibodies are important tools are used in basic research as well as, in diagnosis, imaging and treatment of immunodeficiency diseases, infections and cancers.
Behzad Baradaran +5 more
core +1 more source
Chapter 5. Potential contribution of sero-epidemiological analysis for monitoring malaria control and elimination: historical and current perspectives. [PDF]
, 2009 Anti-malarial antibody responses represent an individual's history of exposure to the disease and, as age sero-conversion rates, reflect cumulative malaria exposure in a population.
Jackie Cook +3 more
core +1 more source