Results 111 to 120 of about 8,957 (228)

Differences in IgG Sialylation Distinguish Asymptomatic From Symptomatic Antinuclear Antibody–Positive Individuals

Arthritis &Rheumatology, Volume 78, Issue 1, Page 243-254, January 2026.
Objective The transition from asymptomatic antinuclear antibody (ANA) positivity to systemic autoimmune rheumatic disease (SARD) is associated with increased production of proinflammatory factors such as tumor necrosis factor α (TNFα). Here we investigate whether the relative absence of inflammation in asymptomatic ANA+ individuals (ANA+NS) results ...
Carolina Muñoz‐Grajales, Carmen C. Ucciferri, Sindhu R. Johnson, Zahi Touma, Zareen Ahmad, Dennisse Bonilla, Linda T. Hiraki, Arthur Bookman, Joan E. Wither   +8 more
wiley   +1 more source

Serum Levels of Anti-Citrullinated Protein Antibody (ACPA) and TWEAK in Patients with Rheumatoid Arthritis: Association with Disease Activity and Treatment Modalities

Archives of Rheumatology, 2011
Objectives: In this study, we evaluated the serum levels of a serum TNF-related weak inducer of apoptosis (TWEAK) and anti-citrullinated protein antibody (ACPA) and investigated the possible correlation of these parameters with disease activity, cytokine levels and anti-TNF-alpha treatment in patients with rheumatoid arthritis (RA).
null Murat KARKUCAK, null Erhan ÇAPKIN, null Haşim ÇAKIRBAY, null Ayşe AKYÜZ, null Ahmet ALVER, null Ayşegül CANSU, null Duygu DEMİROK, null Mehmet TOSUN   +7 more
openaire   +2 more sources

Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis [PDF]

, 2017
Objective The pathogenetic mechanisms by which HLA-DRB1 alleles are associated with anticitrullinated peptide antibody (ACPA)-positive rheumatoid arthritis (RA) are incompletely understood. RA high-risk HLA-DRB1 alleles are known to share a common motif,
Anaparti, Vidyanand, Bernstein, Charles N, Bridie Clemens, E, Deutsch, Aaron J, El-Gabalawy, Hani, Ferucci, Elizabeth D, Heemst, Jurgen van, Hitchon, Carol A, Huizinga, Tom, Kedzierska, Katherine, Law, Soi-Cheng, Meng, Xiaobo, Moustakas, Antonis K, Papadopoulos, George K, Raychaudhuri, Soumya, Reid, Hugh H, Robinson, David B, Rossjohn, Jamie, Scally, Stephen W, Smolik, Irene, Sokolove, Jeremy, Thomas, Ranjeny, Ting, Yi Tian, Toes, René E, Woude, Diane van der   +24 more
core   +2 more sources

Lipoxygenase-derived oxylipins are enriched in anti-citrullinated protein antibody (ACPA)-positive individuals at risk for developing rheumatoid arthritis

Arthritis Research & Therapy
Abstract Background Rheumatoid arthritis (RA) is typically preceded by an extended preclinical period where circulating autoantibodies, particularly anti-citrullinated protein antibodies (ACPA), are detectable in the absence of clinical arthritis. Increased dietary intake of anti-inflammatory omega-3 (ω3) polyunsaturated
Liam J. O’Neil, Vidyanand Anaparti, Tanja Winter, Irene Smolik, Xiaobo Meng, Harold M. Aukema, Hani El-Gabalawy   +6 more
openaire   +3 more sources

A cross-sectional investigation into the association between and autoantibodies to citrullinated proteins in a German population

Therapeutic Advances in Musculoskeletal Disease, 2019
Background: Porphyromonas gingivalis (P.g) is unique among pathogens due to its ability to generate citrullinated proteins in an inflammatory milieu, potentially mediating the loss of immune tolerance, the production of anticitrullinated protein ...
Kolade Oluwagbemigun, Tülay Yucel-Lindberg, Thomas Dietrich, Gregory Tour, Natalia Sherina, Monika Hansson, Manuela Bergmann, Karin Lundberg, Heiner Boeing   +8 more
doaj   +1 more source

Molecular and epidemiological investigations of lung involvement in very early Rheumatoid arthritis [PDF]

, 2015
Rheumatoid arthritis (RA) is a systemic inflammatory joint disease with at least two distinct clinical phenotypes defined by the presence or absence of antibodies, i.e. rheumatoid factor (RF) and/or anti-­‐citrullinated protein antibodies (ACPAs).
Reynisdottir, Gudrun Björk
core   +1 more source

Recurrent Remitting Seronegative Symmetrical Synovitis With Pitting Edema in a Nonagenarian: An Atypical Clinical Course Requiring Methotrexate for Remission

Journal of General and Family Medicine, Volume 27, Issue 1, January 2026.
ABSTRACT Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is a rare inflammatory arthritis of older adults. We report a 92‐year‐old man who presented with fatigue and distal pitting edema, fulfilling the clinical features of RS3PE.
Ken Sato
wiley   +1 more source

Sequencing of the MHC region defines HLA-DQA1 as the major independent risk for anti-citrullinated protein antibodies (ACPA)-positive rheumatoid arthritis in Han population [PDF]

, 2018
ABSTRACTThe strong genetic contribution of the major histocompatibility complex (MHC) to rheumatoid arthritis (RA) susceptibility has been generally attributed to HLA-DRB1. However, due to the high linkage disequilibrium in the MHC region, it is difficult to define the ‘real’ or/and additional independent genetic risks using the conventional HLA ...
Guo, Jianping, Zhang, Tao, Cao, Hongzhi, Li, Xiaowei, Liang, Hao, Liu, Mengru, Zou, Yundong, Zhang, Yuanwei, Sun, Xiaolin, Hu, Fanlei, Du, Yan, Mo, Xiaodong, Liu, Xu, Yang, Yue, Yang, Huanjie, Wu, Xinyu, Zhang, Xuewu, Jia, Huijue, Jiang, Hui, Hou, Yong, Liu, Xin, Su, Yin, Zhang, Mingrong, Yang, Huanming, Wang, Jian, Sun, Liangdan, Liu, Liang, Padyukov, Leonid, Lai, Luhua, Yamamoto, Kazuhiko, Zhang, Xuejun, Klareskog, Lars, Xu, Xun, Li, Zhanguo   +33 more
openaire   +1 more source

Identification of genetic variants and their implications in autoimmunity [PDF]

, 2017
Autoimmune disorders start to develop when the body’s immune system recognizes organs and tissues as foreign and initiates uncontrolled immune reactions against them.
Norin, Ulrika
core   +1 more source

Pathogenic role of immune cells in rheumatoid arthritis: Implications in clinical treatment and biomarker development [PDF]

, 2018
Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic, inflammatory disorder that affects synovial joints, both small and large joints, in a symmetric pattern.
Chow, Sook Khuan *, Peh, Suat Cheng *, Tee, Sabrina Zi Yi *, Teow, Sin Yeang *, Wong, Magdelyn Mei Theing *, Yap, Hooi Yeen *   +5 more
core   +1 more source