Results 191 to 200 of about 8,957 (228)
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Journal of Periodontology, 2015
Background: This study examines: 1) alveolar bone loss (ABL), a hallmark of periodontitis, in anti‐citrullinated protein antibody (ACPA)‐positive rheumatoid arthritis (RA) patients versus control patients with osteoarthritis (OA); and 2) the association of ABL with RA disease activity and ACPA concentrations, including multiple antigen–specific ACPA ...
Shawneen M, Gonzalez +12 more
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Background: This study examines: 1) alveolar bone loss (ABL), a hallmark of periodontitis, in anti‐citrullinated protein antibody (ACPA)‐positive rheumatoid arthritis (RA) patients versus control patients with osteoarthritis (OA); and 2) the association of ABL with RA disease activity and ACPA concentrations, including multiple antigen–specific ACPA ...
Shawneen M, Gonzalez +12 more
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Annals of the Rheumatic Diseases, 2012
Background Anti-citrullinated protein antibodies (ACPA), the most specific markers of rheumatoid arthritis (RA), are found in approximately 50% of patients with palindromic rheumatism (PR). A significant proportion of these patients may evolve to RA. Objectives To analyze the clinical significance of serial measurements of ACPA in patients with PR ...
S.R. Cabrera-Villalba +6 more
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Background Anti-citrullinated protein antibodies (ACPA), the most specific markers of rheumatoid arthritis (RA), are found in approximately 50% of patients with palindromic rheumatism (PR). A significant proportion of these patients may evolve to RA. Objectives To analyze the clinical significance of serial measurements of ACPA in patients with PR ...
S.R. Cabrera-Villalba +6 more
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Annals of the Rheumatic Diseases, 2012
Objectives Anti-citrullinated protein antibodies (ACPA) are specific for Rheumatoid Arthritis (RA) and have been implicated in disease pathogenesis. Previously we have shown that ACPA display a considerably lower avidity as compared to antibodies against recall antigens. Nonetheless, ACPA-avidity did vary between patients. As antibody-mediated effects
A. Willemze +10 more
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Objectives Anti-citrullinated protein antibodies (ACPA) are specific for Rheumatoid Arthritis (RA) and have been implicated in disease pathogenesis. Previously we have shown that ACPA display a considerably lower avidity as compared to antibodies against recall antigens. Nonetheless, ACPA-avidity did vary between patients. As antibody-mediated effects
A. Willemze +10 more
openaire +1 more source
2023
Rheumatoid arthritis (RA) is the most prevalent form of arthritis worldwide. It is characterized by chronic systemic and localized inflammation and takes a progressive course eventually leading to joint destruction if remained untreated. RA is considered to be a disease of autoimmune origin, with rheumatoid factor and anti-citrullinated protein ...
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Rheumatoid arthritis (RA) is the most prevalent form of arthritis worldwide. It is characterized by chronic systemic and localized inflammation and takes a progressive course eventually leading to joint destruction if remained untreated. RA is considered to be a disease of autoimmune origin, with rheumatoid factor and anti-citrullinated protein ...
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ACPA (anti-citrullinated protein antibodies) and rheumatoid arthritis.
Acta reumatologica portuguesa, 2011It has recently been discovered that anti-citrullinated protein antibodies (ACPA) are present in 50% of patients with early rheumatoid arthritis (RA). Assays for detecting ACPA have been shown to have very good diagnostic and predictive characteristics, and they may facilitate the identification of patients with early arthritis who need aggressive ...
Toes, R.E.M., Woude, D. van der
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Annals of the Rheumatic Diseases, 2015
Background In rheumatoid arthritis (RA) a biological hypothesis has been proposed linking smoking with citrullination, anti-citrulline autoimmunity and ACPA-positive RA1. An interaction has been described between smoking and the HLA-DRB1 shared epitope (SE) alleles for ACPA-positive RA, but this interaction has not been investigated in relation to the ...
T.J. van Wesemael +9 more
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Background In rheumatoid arthritis (RA) a biological hypothesis has been proposed linking smoking with citrullination, anti-citrulline autoimmunity and ACPA-positive RA1. An interaction has been described between smoking and the HLA-DRB1 shared epitope (SE) alleles for ACPA-positive RA, but this interaction has not been investigated in relation to the ...
T.J. van Wesemael +9 more
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Annals of the Rheumatic Diseases, 2012
Background The complex processes of citrullination presents an ubiquitous pathophysiological procedure during inflammation. However, anti-citrullinated protein antibodies (ACPA) are highly specific for the rheumatoid arthritis (RA). In order to a variety of several autoimmune phenomenons during the course of lymphoma diseases the occurrence of ...
G. Assmann +5 more
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Background The complex processes of citrullination presents an ubiquitous pathophysiological procedure during inflammation. However, anti-citrullinated protein antibodies (ACPA) are highly specific for the rheumatoid arthritis (RA). In order to a variety of several autoimmune phenomenons during the course of lymphoma diseases the occurrence of ...
G. Assmann +5 more
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The Journal of the Association of Physicians of India, 2019
To evaluate the prevalence of anti- citrullinated protein antibodies (ACPA) in patients with a variety of rheumatic diseases other than rheumatoid arthritis (RA).144 cases of rheumatic diseases other than rheumatoid arthritis (RA) over a period of 1 year were recruited after consenting and followed up for 2 years.
Renu, Saigal +3 more
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To evaluate the prevalence of anti- citrullinated protein antibodies (ACPA) in patients with a variety of rheumatic diseases other than rheumatoid arthritis (RA).144 cases of rheumatic diseases other than rheumatoid arthritis (RA) over a period of 1 year were recruited after consenting and followed up for 2 years.
Renu, Saigal +3 more
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Annals of the Rheumatic Diseases, 2014
Background Anti-citrullinated protein antibody (ACPA) is a serum biomarker that is as sensitive as, but more specific than the rheumatoid factor (RF) and detected earlier in RA [1,2]. Although ACPAs are part of the ACR RA classification criteria, ACPA testing is not routinely paid for/accessible in all jurisdictions. Objectives The impact of missing
J. Shu +8 more
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Background Anti-citrullinated protein antibody (ACPA) is a serum biomarker that is as sensitive as, but more specific than the rheumatoid factor (RF) and detected earlier in RA [1,2]. Although ACPAs are part of the ACR RA classification criteria, ACPA testing is not routinely paid for/accessible in all jurisdictions. Objectives The impact of missing
J. Shu +8 more
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2023
RA is an autoimmune disease that primarily impacts joints throughout the body. The disease can result in pain, stiffness, and reduced mobility. It is a chronic disease, meaning that it lasts a long time and can worsen over time if left untreated. As the disease progresses, it can lead to joint deformity and severe pain, which can significantly impact ...
openaire +1 more source
RA is an autoimmune disease that primarily impacts joints throughout the body. The disease can result in pain, stiffness, and reduced mobility. It is a chronic disease, meaning that it lasts a long time and can worsen over time if left untreated. As the disease progresses, it can lead to joint deformity and severe pain, which can significantly impact ...
openaire +1 more source