Astragalus Mongholicus: A review of its anti-fibrosis properties. [PDF]
Front Pharmacol, 2022 Background: Fibrosis-related diseases (FRD) include cerebral fibrosis, pulmonary fibrosis, cardiac fibrosis, liver fibrosis, renal fibrosis, peritoneal fibrosis, etc. The effects of fibrosis can be severe, resulting in organ dysfunction, functional decline, and even organ failure, which can cause serious health problems.Aim: Currently, there is no ...
Gong F, Qu R, Li Y, Lv Y, Dai J.
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Design, Synthesis and Anti-fibrosis Activity Study of N1-Substituted Phenylhydroquinolinone Derivatives [PDF]
Molecules, 2012 Pirfenidone (5-methyl-1-phenyl-2(1H)-pyridone, PFD) is a small-molecule compound acting on multiple targets involved in pathological fibrogenesis and is effective to increase the survival of patients with fibrosis, such as idiopathic pulmonary fibrosis ...
Jun Chen +5 more
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Dr AFC: drug repositioning through anti-fibrosis characteristic. [PDF]
Brief Bioinform, 2021 AbstractFibrosis is a key component in the pathogenic mechanism of many diseases. These diseases involving fibrosis may share common mechanisms, therapeutic targets and therefore, common intervention strategies and medicines may be applicable for these diseases.
Wu D +10 more
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Synthesis and evaluation of new pirfenidone derivatives as anti-fibrosis agents. [PDF]
RSC Adv, 2022 Two series of new pirfenidone derivatives were synthesized and evaluated as anti-fibrosis agents. Among them, compound 9d give 35 μM of the IC50 against the human fibroblast cell line HFL1.
Gu C +7 more
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The research progress of anti-inflammatory and anti-fibrosis treatment of chronic pancreatitis. [PDF]
Front Oncol, 2022 Chronic pancreatitis (CP) is a chronic progressive inflammatory disease of the pancreas, caused by multiple factors and accompanied by irreversible impairment of pancreatic internal and external secretory functions. Pathologically, atrophy of the pancreatic acini, tissue fibrosis or calcification, focal edema, inflammation, and necrosis are observed ...
Li BQ +7 more
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Effect of Extracellular Matrix Stiffness on Candesartan Efficacy in Anti-Fibrosis and Antioxidation. [PDF]
Antioxidants (Basel), 2023 Myocardial fibrosis progression and imbalanced redox state are closely associated with increased extracellular matrix (ECM) stiffness. Candesartan (CAN), an angiotensin II (Ang II) receptor inhibitor, has shown promising anti-fibrosis and antioxidant efficacy in previous cardiovascular disease studies.
Zhu T +9 more
europepmc +4 more sources
Mesenchymal Stem/Stromal Cells in Progressive Fibrogenic Involvement and Anti-Fibrosis Therapeutic Properties. [PDF]
Front Cell Dev Biol, 2022 Fibrosis refers to the connective tissue deposition and stiffness usually as a result of injury. Fibrosis tissue-resident mesenchymal cells, including fibroblasts, myofibroblast, smooth muscle cells, and mesenchymal stem/stromal cells (MSCs), are major players in fibrogenic processes under certain contexts.
Li C, Wang B.
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Fibrotic microtissue array to predict anti-fibrosis drug efficacy. [PDF]
Nat Commun, 2018 AbstractFibrosis is a severe health problem characterized by progressive stiffening of tissues which causes organ malfunction and failure. A major bottleneck in developing new anti-fibrosis therapies is the lack of in vitro models that recapitulate dynamic changes in tissue mechanics during fibrogenesis.
Asmani M +7 more
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Modeling mechanical activation of macrophages during pulmonary fibrogenesis for targeted anti-fibrosis therapy. [PDF]
Sci Adv, 2023 Pulmonary fibrosis is an often fatal lung disease. Immune cells such as macrophages were shown to accumulate in the fibrotic lung, but their contribution to the fibrosis development is unclear. To recapitulate the involvement of macrophages in the development of pulmonary fibrosis, we developed a fibrotic microtissue model with cocultured human ...
Xu Y, Ying L, Lang JK, Hinz B, Zhao R.
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Ferroptosis: new insight into the mechanisms of diabetic nephropathy and retinopathy
Frontiers in Endocrinology, 2023 Diabetic nephropathy (DN) and diabetic retinopathy (DR) are the most serious and common diabetes-associated complications. DN and DR are all highly prevalent and dangerous global diseases, but the underlying mechanism remains to be elucidated ...
Luxin Li +15 more
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