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Discovery of triazolyl thalidomide derivatives as anti-fibrosis agents

New Journal of Chemistry, 2021
Triazolyl thalidomide derivative10einhibits fibrogenesis by SOCE and TGF-β1/SMAD2/3 signaling pathways.
Kai-Wei Tang   +5 more
openaire   +1 more source

Fibrosis on a Chip for Screening of Anti-Fibrosis Drugs

2021
Idiopathic pulmonary fibrosis (IPF) is a chronic pathological disorder that targets alveoli interstitial tissues and is characterized by the progressive stiffening of alveolar membrane. The median survival rate of the patients with IPF is less than 5 years.
Mohammadnabi, Asmani, Ruogang, Zhao
openaire   +2 more sources

Earthworm protease in anti-thrombosis and anti-fibrosis

Biochimica et Biophysica Acta (BBA) - General Subjects, 2019
Earthworms are widely used in basic and applied research in medicine, food, environment and agriculture, in which for instance earthworm protease has its own biochemical features.This review summarizes earthworm protease biochemical features in anti-thrombosis and anti-fibrosis, and provides new perspectives for earthworm to be used in biochemical and ...
Xiu-Mei, Wang   +4 more
openaire   +2 more sources

Anti-Fibrosis Therapy and Diabetic Nephropathy

Current Diabetes Reports, 2012
Diabetes mellitus is rapidly becoming a global health issue that may overtake cancer during the next two decades as it covertly affects multiple organ systems that goes undiagnosed long after the onset. A number of complications are associated with poorly controlled hyperglycemia. Diabetic nephropathy is one of the most common complications of diabetes
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A new glucomannan from Bletilla striata: Structural and anti-fibrosis effects

Fitoterapia, 2014
A novel water-soluble polysaccharide, designated Bletilla striata polysaccharide b (BSPb), was isolated from a traditional Chinese medicinal herb, Bletilla striata. The crude polysaccharide was obtained by hot water extraction and purified by ion-exchange chromatography.
Ying, Wang   +5 more
openaire   +2 more sources

Cytoglobin Exhibits Anti-Fibrosis Activity on Liver In Vivo and In Vitro

The Protein Journal, 2011
Cytoglobin, generated using genetic engineering method, is a kind of recombinant human stellate cell activation-associated protein. We speculate that it could influence the development of hepatic fibrosis like Sellate cell activation-associated protein which was discovered by Kawada et al.
Xin, He   +6 more
openaire   +2 more sources

Anti‐fibrosis effect of BMP‐7 peptide functionalization on cobalt chromium alloy

Journal of Orthopaedic Research, 2013
AbstractOrthopedic metallic prosthetic implants are commonly made of cobalt chromium (CoCr) alloys. However, such metal‐based implants are susceptible to fibrous capsule formation on the implant surface after implantation. At the bone‐implant interface, this capsule can prevent implant integration, resulting in loosening and failure.
Hark Chuan, Tan   +3 more
openaire   +2 more sources

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