Results 261 to 270 of about 350,217 (297)

A stimuli-responsive drug release nanoplatform for kidney-specific anti-fibrosis treatment

Biomaterials Science, 2019
A Stimuli-responsive drug release nanoassemblies (GLAuNPs-Co) had selective kidney targeting, pH-triggered and drug-releasable abilities for renal fibrosis.
Lishan Tan, Xuandi Lai, Mengbi Zhang, Tao Zeng, Youhua Liu, Xiulong Deng, Minzi Qiu, Jiawen Li, Guang Zhou, Meng Yu, Xinran Geng, Jianqiang Hu, Aiqing Li   +12 more
openaire   +2 more sources

Liver Anti-Fibrosis Therapy with Mesenchymal Stem Cells Secreting Hepatocyte Growth Factor

Journal of Biomaterials Science, Polymer Edition, 2012
The objective of this study is to investigate the anti-fibrotic effect of combined mesencymal stem cells (MSCs) and gene therapy on liver fibrosis. When transfected by the complex with a plasmid DNA of hepatocyte growth factor (HGF) and the spermine-introduced pullulan of gene carrier, MSCs secreted HGF protein over 1 week.
Hidefumi, Ishikawa, Jun-Ichiro, Jo, Yasuhiko, Tabata   +2 more
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A molecular basis for the anti‐inflammatory and anti‐fibrosis properties of cannabidiol

The FASEB Journal, 2020
Abstract Cannabidiol (CBD) is considered a non‐psychoactive, antioxidant, and anti‐inflammatory compound derived from the Cannabis sativa plant. There are various reports on the versatile function of CBD, including ameliorating chronic inflammation and fibrosis formation in several tissue types.
Falone, Sunda, Afolake, Arowolo
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Design, synthesis and biological evaluation studies of novel anti-fibrosis agents bearing sulfoxide moiety

Bioorganic & Medicinal Chemistry, 2022
Fibrosis, a chronic disease with high morbidity and mortality, is mainly characterized by excessive accumulation of extracellular matrix (ECM). At present, pathogenesis of fibrosis is incompletely understood, and there is an urgent need to develop safe and effective drugs.
Shixuan, Jiao, Wanqiu, Huang, Zhijun, Cao, Ya, Chen, Siliang, Chen, Zhongcheng, Yang, Wenxin, Wang, Huixin, Yao, Xuekun, Wang, Zheng, Li, Luyong, Zhang   +10 more
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Human adipose mesenchymal stem cells as potent anti-fibrosis therapy for systemic sclerosis

Journal of Autoimmunity, 2016
Displaying immunosuppressive and trophic properties, mesenchymal stem/stromal cells (MSC) are being evaluated as promising therapeutic options in a variety of autoimmune and degenerative diseases. Although benefits may be expected in systemic sclerosis (SSc), a rare autoimmune disease with fibrosis-related mortality, MSC have yet to be evaluated in ...
Alexandre T.J. Maria, Karine Toupet, Marie Maumus, Guillaume Fonteneau, Alain Le Quellec, Christian Jorgensen, Philippe Guilpain, Danièle Noël   +7 more
openaire   +2 more sources

Design and evaluation of anti-fibrosis drug engineered resealed erythrocytes for targeted delivery

Drug Delivery and Translational Research, 2019
Resealed erythrocytes (RSE) are potential, site-specific carrier system for drug delivery with prolonged drug release activity. In this study, erythrocytes obtained from Wistar albino rats were loaded with ambroxol hydrochloride (AH) with the focus to convenience the lung targeting possibility of the carrier erythrocytes.
Piyali, Dey, Subham, Banerjee, Santa, Mandal, Pronobesh, Chattopadhyay   +3 more
openaire   +2 more sources

[Anti-fibrosis effects of fenofibrate in mice with hepatic fibrosis].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2014
To investigate the anti-fibrosis effects and mechanisms of fenofibrate on hepatic fibrosis using a mouse model of fibrosis induced by carbon tetrachloride (CCl4).Twenty-six male C57BL mice were divided into the following three groups: CCL4-induced untreated model control (n = 10), CCl4-induced fenofibrate-treated model (n = 10), and uninduced/untreated
Cong, Xie, Long, Li, Ya-ping, Xu, Yue-yong, Zhu, Jia-ji, Jiang   +4 more
openaire   +1 more source

[Anti-fibrosis of liver, Shouder heavy responsibilities].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2019
In recent years, many studies have been conducted on liver fibrosis. This article introduces the latest advances in the pathogenesis, diagnosis, and treatment of liver fibrosis. There is still a long way to go for the research on anti-fibrosis therapy, and this difficult problem will finally be solved with the help of further studies.
openaire   +1 more source

[The action of decorin in anti-fibrosis and anti-cancer].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2009
Decorin (DCN) is a member of the small leucine-rich proteoglycan gene family. Many studies indicated that DCN inhibited fibrosis and scar-formation by neutralization of TGF-P and interfering the binding of TGF-beta with its receptor, which induced ectopic deposition of extracellular matrix. Additionally, DCN can prevent the proliferation and metastasis
Weifeng, Ma, Yi, Tan, Shaohui, Cai, Hongyuan, Chen, Jun, Du, Shaoxi, Cai   +5 more
openaire   +1 more source

Anti-fibrosis and anti-cirrhosis effects of Rhizoma paridis saponins on diethylnitrosamine induced rats

Journal of Ethnopharmacology, 2014
Paris polyphylla var. yunnanensis as a traditional Chinese medicine has been used in the treatment of liver disease for thousands of years. Rhizoma paridis saponins (RPS), as the main active components of Paris polyphylla, have been used to treat liver injury.
Shuli, Man, Wei, Fan, Wenyuan, Gao, Yuanyuan, Li, Yan, Wang, Zhen, Liu, Hongfa, Li   +6 more
openaire   +2 more sources