Results 21 to 30 of about 350,217 (297)

Cyclic Stretching of Fibrotic Microtissue Array for Evaluation of Anti-Fibrosis Drugs. [PDF]

Cell Mol Bioeng, 2019
Progression of pulmonary fibrosis, characterized by the deterioration of lung tissue's mechanical properties, is affected by respiratory motion-induced dynamic loading. Since the development of anti-fibrosis drugs faces major hurdles in animal tests and human clinical trials, preclinical models that can recapitulate fibrosis progression under ...
Asmani M, Kotei C, Hsia I, Marecki L, Wang T, Zhou C, Zhao R.   +6 more
europepmc   +4 more sources

The Anti-Fibrotic Effect of Cold Atmospheric Plasma on Localized Scleroderma In Vitro and In Vivo

Biomedicines, 2021
Cold Atmospheric Plasma (CAP) has shown promising results in the treatment of various skin diseases. The therapeutic effect of CAP on localized scleroderma (LS), however, has not yet been evaluated.
Stephanie Arndt, Petra Unger, Anja-Katrin Bosserhoff, Mark Berneburg, Sigrid Karrer   +4 more
doaj   +1 more source

Exosome-mediated aptamer S58 reduces fibrosis in a rat glaucoma filtration surgery model [PDF]

International Journal of Ophthalmology, 2022
AIM: To confirm whether exosome-mediated delivery of aptamer S58 (Exo-S58) has a better antifibrotic effect than naked S58 in human conjunctival fibroblasts (HConFs) and a rat glaucoma filtration surgery (GFS) model.
Qian-Yi Lin, Xiang-Ji Li, Yu Leng, Xiao-Min Zhu, Min Tang, Yi Lin, Wang-Du Luo, Bing-Cai Jiang, Xia Chen, Lin Xie   +9 more
doaj   +1 more source

Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects [PDF]

, 2015
Chronic liver dysfunction or injury is a serious health problem worldwide. Chronic liver disease involves a wide range of liver pathologies that include fatty liver, hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma.
Feng, Y, HONG, M, LI, S, TAN, HY, Tsao, GSW, Wang, N   +5 more
core   +5 more sources

Perspectives of PDE inhibitor on treating idiopathic pulmonary fibrosis

Frontiers in Pharmacology, 2023
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD) without an identifiable cause. If not treated after diagnosis, the average life expectancy is 3–5 years.
Xudan Yang, Zhihao Xu, Songhua Hu, Juan Shen   +3 more
doaj   +1 more source

Ranunculus ternatus Thunb extract attenuates renal fibrosis of diabetic nephropathy via inhibiting SMYD2

Pharmaceutical Biology, 2022
Context Ranunculus ternatus Thunb (Ranunculaceae), (RTT) is used clinically for the treatment of tuberculosis or as tumour adjuvant therapy, but its potential effect on diabetic nephropathy (DN) has not been studied.
Weiwei Xu, Rui Peng, Siyu Chen, Congcong Wu, Xiaoxiao Wang, Ting Yu, Jiuying Jian, Ni Zhang, Siyang Zuo, Min Chen, Bing Guo, Lirong Liu   +11 more
doaj   +1 more source

State of the ART: Drug Screening Reveals Artesunate as a Promising Anti-Fibrosis Therapy. [PDF]

J Respir Biol Transl Med
Fibrosis is a progressive pathological process that severely impairs normal organ function. Current treatments for fibrosis are extremely limited, with no curative approaches available. In a recent article published in Cell, Zhang and colleagues employed drug screening using ACTA2 reporter iPSC-derived cardiac fibroblasts and identified artesunate as a
Qiao Y, Liang J, Jiang D.
europepmc   +3 more sources

Erythropoietin-Modified Mesenchymal Stem Cells Enhance Anti-fibrosis Efficacy in Mouse Liver Fibrosis Model. [PDF]

Tissue Eng Regen Med, 2020
Mesenchymal stem cell (MSC)-based cell transplantation is an effective means of treating chronic liver injury, fibrosis and end-stage liver disease. However, extensive studies have found that only a small number of transplanted cells migrate to the site of injury or lesion, and repair efficacy is very limited.Bone marrow-derived MSCs (BM-MSCs) were ...
Wang X, Wang H, Lu J, Feng Z, Liu Z, Song H, Wang H, Zhou Y, Xu J.   +8 more
europepmc   +4 more sources

Autophagy Inhibitor Chloroquine Downmodulates Hepatic Stellate Cell Activation and Liver Damage in Bile-Duct-Ligated Mice

Cells, 2023
Hepatic stellate cell (HSC) activation via the autophagy pathway is a critical factor in liver fibrogenesis. This study tests the hypothesis that chloroquine (CQ) treatment can prevent autophagy and HSC activation in vitro and in vivo in bile-duct ...
Trinh Van Le, Hong-Thuy Phan-Thi, My-Xuan Huynh-Thi, Thanh Minh Dang, Ai Xuan Le Holterman, Gabriele Grassi, Thao-Uyen Nguyen-Luu, Nhung Hai Truong   +7 more
doaj   +1 more source

Anti-Ro52 Antibody as a Protective Factor for Pulmonary Fibrosis in Primary Sjögren's Syndrome [PDF]

Iranian Journal of Immunology, 2022
Background: Pulmonary fibrosis is common in primary Sjögren's syndrome (pSS)-related interstitial lung disease (ILD). However, research is lacking on the diagnostic immunological examination of pSS-related pulmonary fibrosis.
Defu Li, Hongbing Li, Wei Li, Tingting Zhu   +3 more
doaj   +1 more source