Results 31 to 40 of about 350,217 (297)

Unraveling the biological functions of Smad7 with mouse models [PDF]

, 2011
Smad7 is a key negative regulator of the transforming growth factor β (TGF-β) signaling and plays an important role in modulating a large array of biological processes.
Lu Zhu, Susie Chen, Yan Chen
core   +1 more source

Pharmacological Activities and Mechanisms of Hirudin and Its Derivatives - A Review

Frontiers in Pharmacology, 2021
Hirudin, an acidic polypeptide secreted by the salivary glands of Hirudo medicinalis (also known as “Shuizhi” in traditional Chinese medicine), is the strongest natural specific inhibitor of thrombin found so far. Hirudin has been demonstrated to possess
Chen Junren, Chen Junren, Xie Xiaofang, Xie Xiaofang, Zhang Huiqiong, Zhang Huiqiong, Li Gangmin, Li Gangmin, Yin Yanpeng, Yin Yanpeng, Cao Xiaoyu, Cao Xiaoyu, Gao Yuqing, Gao Yuqing, Li Yanan, Li Yanan, Zhang Yue, Zhang Yue, Peng Fu, Peng Fu, Peng Fu, Peng Cheng, Peng Cheng   +22 more
doaj   +1 more source

Thermal stress induces glycolytic beige fat formation via a myogenic state. [PDF]

, 2019
Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue.
A Jaworski, AA Lans van der, Andrew Brack, Annarita Scaramozza, C Trapnell, Carlos Henrique Sponton, DC Berry, ES Bachman, H Ohno, J Nedergaard, J Sanchez-Gurmaches, J Wu, JR Arch, JZ Long, K Ikeda, K Nishijo, K Shinoda, Kazuki Tajima, Kenji Ikeda, Kosaku Shinoda, Kyeongkyu Kim, L Kazak, L Vishvanath, L Ye, LZ Sharp, M Razzoli, ME Lidell, MJ Hanssen, ML Gantner, MS Rodeheffer, P Cohen, P Seale, Qiang Wang, S Collins, S Heinz, S Jung, S Kajimura, S Tripathi, Shingo Kajimura, T Buch, T Yoneshiro, Takeshi Yoneshiro, VK Mootha, Y Hasegawa, YH Lee, YH Tseng, Yong Chen, Zachary Brown, ZF Yang   +48 more
core   +2 more sources

Potential use of the human amniotic membrane as a scaffold in human articular cartilage repair [PDF]

, 2010
[Abstract] The human amniotic membrane (HAM) is an abundant and readily obtained tissue that may be an important source of scaffold for transplanted chondrocytes in cartilage regeneration in vivo.
Blanco García, Francisco J, De-Toro, Javier, Díaz-Prado, Silvia, Fuentes Boquete, Isaac Manuel, Hermida Gómez, Tamara, Muiños-López, Emma, Rendal Vázquez, María Esther, Rodríguez-Cabarcos, Margarita   +7 more
core   +2 more sources

Gypenosides Protect Orbital Fibroblasts in Graves Ophthalmopathy via Anti-Inflammation and Anti-Fibrosis Effects. [PDF]

Invest Ophthalmol Vis Sci, 2020
To investigate the effect of Gypenosides (Gyps) on the inflammation and fibrosis in orbital fibroblasts (OFs) in Graves ophthalmopathy (GO).Bioinformatics analyses were performed to identify the enriched genes and signaling pathways related to Gyps function.
Li H, Ma C, Liu W, He J, Li K.
europepmc   +3 more sources

Anti-Fibrosis Effect of Panax ginseng and Inula japonica Formula in Human Pulmonary Fibroblasts. [PDF]

Nutrients
Panax ginseng Meyer and Inula japonica Thunb. are well established in traditional medicine and are known for their therapeutic properties in managing a range of ailments such as diabetes, asthma, and cancer. Although P. ginseng and I. japonica can alleviate pulmonary fibrosis (PF), the anti-fibrosis effect on PF by the combination of two herbal ...
Jung Y, Yim NH, Lee SM, Cho WK, Cha MH, Ma JY.   +5 more
europepmc   +3 more sources

The 22nd annual meeting of the European Tissue Repair Society (ETRS) in Athens, Greece [PDF]

, 2013
The 22nd Annual Meeting of the European Tissue Repair Society, Athens, Greece, October 4 to 5, 2012 informed about pathophysiological mechanisms in tissue repair and on the development of clinical treatments of chronic wounds, fibrosis, and cancer ...
Beele, Hilde, Hinz, Boris, Kletsas, Dimitris, Ulrich, Magda   +3 more
core   +2 more sources

Total Flavone of Abelmoschus manihot Ameliorates TNBS-Induced Colonic Fibrosis by Regulating Th17/Treg Balance and Reducing Extracellular Matrix

Frontiers in Pharmacology, 2021
Background and Aims: Surgery remains the major available strategy in inflammatory bowel disease (IBD) fibrotic strictures because no available drugs have sufficient prevention and treatment in this complication.
Lichao Qiao, Lichao Qiao, Lei Fang, Junyi Zhu, Yu Xiang, Yu Xiang, Haixia Xu, Haixia Xu, Xueliang Sun, Xueliang Sun, Hongjin Chen, Bolin Yang   +11 more
doaj   +1 more source

The Effects of Angiotensin Converting Enzyme Inhibitors (ACE-I) on Human N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) Levels: A Systematic Review and Meta-Analysis [PDF]

, 2015
BACKGROUND: Tuberculous pericardial effusion is a pro-fibrotic condition that is complicated by constrictive pericarditis in 4% to 8% of cases. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a ubiquitous tetrapeptide with anti-fibrotic properties ...
Mnguni, Ayanda Trevor, Engel, Mark E, Borkum, Megan S, Mayosi, Bongani M   +3 more
core   +2 more sources

Eccentric and concentric cardiac hypertrophy induced by exercise training: microRNAs and molecular determinants [PDF]

, 2011
Among the molecular, biochemical and cellular processes that orchestrate the development of the different phenotypes of cardiac hypertrophy in response to physiological stimuli or pathological insults, the specific contribution of exercise training has ...
Fernandes, T., Oliveira, E.M., Soci, U.P.R.   +2 more
core   +3 more sources