Results 51 to 60 of about 350,217 (297)

Dissection of the mechanism of traditional Chinese medical prescription-Yiqihuoxue formula as an effective anti-fibrotic treatment for systemic sclerosis [PDF]

, 2014
BACKGROUND: Systemic sclerosis (SSc) is a connective tissue fibrotic disease for which there is no effective treatment. Traditional Chinese Medicine (TCM), such as the Yiqihuoxue formula used in Shanghai TCM-integrated Hospital, has shown the efficacy of
Dongdong Chen, Haiyan Chu, Hejian Zou, Jin Yuan, Jiucun Wang, Li Jin, Ling Yu, Mengmeng Song, Qingmei Liu, Ting Wu, Wenyu Wu, Wenzhen Tu, Xiaodong Zhou, Yanyun Ma   +13 more
core   +2 more sources

Identification of Two Novel Anti-Fibrotic Benzopyran Compounds Produced by Engineered Strains Derived from Streptomyces xiamenensis M1-94P that Originated from Deep-Sea Sediments

Marine Drugs, 2013
The benzopyran compound obtained by cultivating a mangrove-derived strain, Streptomyces xiamenensis strain 318, shows multiple biological effects, including anti-fibrotic and anti-hypertrophic scar properties.
Lei Feng, Xue-Gong Li, Jun Xu, Tie-Sheng Han, Shu-Jie Xie, Min-Juan Xu, Ya-Hui Wang, Zhi-Gang Zhang, Zhong-Yuan You   +8 more
doaj   +1 more source

Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis

Frontiers in Pharmacology, 2023
Background: Inflammation and fibrosis are typical symptoms of non-alcoholic steatohepatitis (NASH), which is one of the most common chronic liver diseases.
Wei Luo, Wei Luo, Wei Luo, Guang Xu, Guang Xu, Guang Xu, Zheng Song, Zheng Song, Wenqing Mu, Wenqing Mu, Wenqing Mu, Jincai Wen, Jincai Wen, Siwen Hui, Siwen Hui, Jia Zhao, Jia Zhao, Jia Zhao, Xiaoyan Zhan, Xiaoyan Zhan, Zhaofang Bai, Zhaofang Bai, Xiaohe Xiao, Xiaohe Xiao, Xiaohe Xiao   +24 more
doaj   +1 more source

Role of bone morphogenetic protein-7 in renal fibrosis [PDF]

, 2015
published_or_final_versio
LI, R, Tang, SCW, Yiu, WH
core   +1 more source

ZYZ-168 alleviates cardiac fibrosis after myocardial infarction through inhibition of ERK1/2-dependent ROCK1 activation [PDF]

, 2017
Selective treatments for myocardial infarction (MI) induced cardiac fibrosis are lacking. In this study, we focus on the therapeutic potential of a synthetic cardio-protective agent named ZYZ-168 towards MI-induced cardiac fibrosis and try to reveal the ...
A Ducharme, A Leask, AE Berezin, C Mera, C Varon, CM Howard, F Klingberg, G Diaz-Araya, H Hirano, H Ji, J Bain, J Heger, J Simova, J Zhang, JC McGrath, JG Cleland, K Kaibuchi, K Kuwahara, KA Harvey, L Li, L Rigassi, M Giannandrea, MC Cho, ME Engel, MS Dzeshka, MT Moore, N Manickam, N Sandbo, P Zhang, PS Tsou, PY Cheung, RJ Nichols, RS Knipe, S Frantz, S Luo, S Mori, SW Rabkin, T Matsui, T-M Lee, XH Liu, Y Cui, Y Rikitake, Y Zhao, YH Liang, YM Zhang, ZS Galis, ZY Hong   +46 more
core   +7 more sources

Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection

Molecules, 2022
Cepharanthine (CEP) has excellent anti-SARS-CoV-2 properties, indicating its favorable potential for COVID-19 treatment. However, its application is challenged by its poor dissolubility and oral bioavailability.
Jian Li, Guangrui Chen, Zhiyun Meng, Zhuona Wu, Hui Gan, Xiaoxia Zhu, Peng Han, Taoyun Liu, Fanjun Wang, Ruolan Gu, Guifang Dou   +10 more
doaj   +1 more source

BMP7 Gene Transfer via Gold Nanoparticles into Stroma Inhibits Corneal Fibrosis In Vivo [PDF]

, 2013
This study examined the effects of BMP7 gene transfer on corneal wound healing and fibrosis inhibition in vivo using a rabbit model. Corneal haze in rabbits was produced with the excimer laser performing -9 diopters photorefractive keratectomy. BMP7 gene
Klibanov, Alexander M., Mohan, Rajiv R., Rieger, Frank G., Rodier, Jason T., Sharma, Ajay, Tandon, Ashish   +5 more
core   +3 more sources

High-Frequency Ultrasound Imaging to Evaluate Liver Fibrosis Progression in Rats and Yi Guan Jian Herbal Therapeutic Effects [PDF]

, 2013
The animals used in liver fibrosis studies must usually be sacrificed. Ultrasound has been demonstrated to have the ability to diagnose hepatic fibrosis and cirrhosis in experimental small-animal models.
Chia-Hui Chuang, Chia-Wen Kuo, Chuan-Mu Chen, Frank ChiahungMao, Hsiao-Ling Chen, Jiun-Yu Chen, Kowit-Yu Chong, Wei Chen, Yu-Tang Tung   +8 more
core   +2 more sources

HIPK2 is a new drug target for anti-fibrosis therapy in kidney disease [PDF]

Frontiers in Physiology, 2015
In vitro and animal studies continue to elucidate the mechanisms of fibrosis and have led to advancements in treatment for idiopathic pulmonary fibrosis and cirrhosis, but the search for treatments for renal fibrosis has been more disappointing. Here, we will discuss homeodomain-interacting-protein kinase 2 (HIPK2), a novel regulator of fibrosis that ...
Melinda M. Nugent, Kyung eLee, John Cijiang He, John Cijiang He   +3 more
openaire   +3 more sources

F127-SE-tLAP thermosensitive hydrogel alleviates bleomycin-induced skin fibrosis via TGF-β/Smad pathway

Molecular Medicine
Background Skin fibrosis affects the normal function of the skin. TGF-β1 is a key cytokine that affects organ fibrosis. The latency-associated peptide (LAP) is essential for TGF-β1 activation.
Zhiqin Cao, Keke Zhang, Jingruo Liu, Yu Pan, Jiayi Shi, Luxin Li, Xiaocan Sun, Shiqi Li, Xiaohuan Yuan, Dan Wu   +9 more
doaj   +1 more source