Results 61 to 70 of about 350,217 (297)

Identification and Characterization of an Anti-Fibrotic Benzopyran Compound Isolated from Mangrove-Derived Streptomyces xiamenensis

Marine Drugs, 2012
An anti-fibrotic compound produced by Streptomyces xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis.
Jun Xu, Song-Lin Yang, Zhi-Gang Zhang, Ping Ao, Wen-Han Lin, Dong Liu, Zhen-Hao Xu, Xiao-Meng Lang, Yi-Lei Zhao, Min-Juan Xu, Xiao-Jin Liu   +10 more
doaj   +1 more source

Anti-Apoptosis and Anti-Fibrosis Effects of Eriobotrya Japonica in Spontaneously Hypertensive Rat Hearts. [PDF]

Int J Mol Sci, 2018
Myocardial apoptosis and fibrosis represent important contributing factors for development of hypertension-induced heart failure. The present study aims to investigate the potential effects of Eriobotrya japonica leaf extract (EJLE) against hypertension-induced cardiac apoptosis and fibrosis in spontaneously hypertensive rats (SHRs).
Chiang JT, Badrealam KF, Shibu MA, Cheng SF, Shen CY, Chang CF, Lin YM, Viswanadha VP, Liao SC, Huang CY.   +9 more
europepmc   +4 more sources

Transcriptional up-regulation of relaxin-3 by Nur77 attenuates β-adrenergic agonist-induced apoptosis in cardiomyocytes. [PDF]

, 2018
The relaxin family peptides have been shown to exert several beneficial effects on the heart, including anti-apoptosis, anti-fibrosis, and anti-hypertrophy activity.
Cheng, Fang, Guo, Zhifu, Liu, Xinzhu, Ma, Xin-Liang, Sun, Jianxin, Yan, Guijun, Yang, Fan, Yi, Bing, You, Xiaohua, Zhao, Xianxian, Zhu, Ni   +10 more
core   +1 more source

Effectiveness of Chinese herbal medicine in treating liver fibrosis: a systematic review and meta-analysis of randomized controlled trials [PDF]

, 2012
Background The studies on the effectiveness of Chinese herbal medicines (CHM) in treating liver fibrosis (LF) were not consistent. This study aims to systematically review the effectiveness of CHM on treating LF patients.
Fan Cheung, Yibin Feng, Ning Wang, Man-Fung Yuen, Yao Tong, Vivian Wong   +5 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

TSG6 Plays a Role in Improving Orbital Inflammatory Infiltration and Extracellular Matrix Accumulation in TAO Model Mice

Journal of Inflammation Research, 2023
Xiuhui He, Siya Chen, Xiaohui Wang, Min Kong, Fangzheng Shi, Xiaoxuan Qi, Yuxin Xu Department of Ophthalmology, Second Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of ChinaCorrespondence: Yuxin Xu, Department of Ophthalmology,
He X, Chen S, Wang X, Kong M, Shi F, Qi X, Xu Y   +6 more
doaj  

Properties of the amniotic membrane for potential use in tissue engineering [PDF]

, 2008
An important component of tissue engineering (TE) is the supporting matrix upon which cells and tissues grow, also known as the scaffold. Scaffolds must easily integrate with host tissue and provide an excellent environment for cell growth and ...
Ahmadiani, A, Ghanavi, J, Jorjani, M, Niknejad, H, Peirovi, H, Seifalian, AM   +5 more
core   +1 more source

Polydatin up-regulates clara cell secretory protein to suppress phospholipase A2 of lung induced by LPS in vivo and in vitro [PDF]

, 2011
Background Lung injury induced by lipopolysaccharide (LPS) remains one of the leading causes of morbidity and mortality in children. The damage to membrane phospholipids leads to the collapse of the bronchial alveolar epithelial barrier ...
Shu Shiyu, Ling Zhiyu, Ye Mao, Bo Lin, Wang Lijia, Zhang Tianbao, Chen Jie, Li Tingyu   +7 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

New Drugs for Hepatic Fibrosis

Frontiers in Pharmacology, 2022
The morbidity and mortality of hepatic fibrosis caused by various etiologies are high worldwide, and the trend is increasing annually. At present, there is no effective method to cure hepatic fibrosis except liver transplantation, and its serious ...
Liang Shan, Liang Shan, Liang Shan, Liang Shan, Fengling Wang, Dandan Zhai, Xiangyun Meng, Jianjun Liu, Xiongwen Lv, Xiongwen Lv, Xiongwen Lv   +10 more
doaj   +1 more source