Results 71 to 80 of about 350,217 (297)
A comparative study on the hepatoprotective action of bear bile and coptidis rhizoma aqueous extract on experimental liver fibrosis in rats [PDF]
, 2012 published_or_final_versio
Cheung, F +6 more
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Frontiers in Pharmacology, 2023 Ganoderma lucidum (G. lucidum, Lingzhi) is a well-known herbal medicine with a variety of pharmacological effects. Studies have found that G. lucidum has pharmacological effects such as antioxidant, antitumor, anti-aging, anti-liver fibrosis, and ...
Haoyuan Peng +9 more
doaj +1 more source
Medical implantable devices for the controlled release of anti-TGF-beta1 in the repair of peripheral nerve injuries [PDF]
, 2004 The development of novel bioartificial nerve grafts which release soluble therapeutic agents, shows great promises guiding the extension of the injured axons and optimizing and improving the degree and specificity of neural outgrowth.
Brown, R.A. +4 more
core
The clinical impact of exosomes in cardiovascular disorders: from basic science to clinical application [PDF]
, 2019 Cardiovascular disease (CVD) is the major cause of death globally; therefore, there is a need for the identification of valid biomarker that accurately predict the risk of developing cardiovascular disease, and novel therapeutic approaches for its ...
Avan, Amir +6 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Pharmacological ResearchTumor necrosis factor α (TNF-α) is an attractive anti-liver fibrosis drug because of its cell apoptosis-inducing ability on activated hepatic stellate cells (HSCs) via TNF-α receptor 1 (TNFR1).
Xiaowen Qiu +11 more
doaj +1 more source
Progress in drug delivery system for fibrosis therapy
Asian Journal of Pharmaceutical Sciences, 2021 Fibrosis is a necessary process in the progression of chronic disease to cirrhosis or even cancer, which is a serious disease threatening human health.
Lei Xing +7 more
doaj +1 more source
Redox and Peroxidase Activities of the Hemoglobin Superfamily: Relevance to Health and Disease [PDF]
, 2016 Significance: Erythrocyte hemoglobin (Hb) and myocyte myoglobin, although primarily oxygen-carrying proteins, have the capacity to do redox chemistry. Such redox activity in the wider family of globins now appears to have important associations with the ...
Brandon J. Reeder +5 more
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source