Results 51 to 60 of about 197,173 (246)

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

A Case of Alport Syndrome with Posttransplant Antiglomerular Basement Membrane Disease despite Negative Antiglomerular Basement Membrane Antibodies by EIA Treated with Plasmapheresis and Intravenous Immunoglobulin

Case Reports in Transplantation, 2013
Posttransplant antiglomerular basement membrane (anti-GBM) disease occurs in approximately 5% of Alport patients and usually ends in irreversible graft failure. Recent research has focused on characterizing the structure of the anti-GBM alloepitope. Here
Sumiko I. Armstead, Thomas Hellmark, Jorgen Wieslander, Xin J. Zhou, Ramesh Saxena, Nilum Rajora   +5 more
doaj   +1 more source

Rituximab in treatment of anti-GBM antibody glomerulonephritis

Medicine, 2019
Abstract Rationale: Anti-glomerular basement membrane (GBM) disease is a T cell-mediated disease that has a poor prognosis with conventional therapy. We tested rituximab as a primary therapy to reduce anti-GBM antibody produced by B cells.
Uematsu-Uchida, Mayu, Ohira, Takehiro, Tomita, Shigeki, Satonaka, Hiroshi, Tojo, Akihiro, Ishimitsu, Toshihiko   +5 more
openaire   +2 more sources

Demographic data, clinical and pathological parameters of anti-GBM patients with anti-P14 antibodies.

, 2015
n = 16 patients. ANCA, antineutrophil cytoplasmic antibody; MPO, myeloperoxidase; PR3, proteinase 3; GBM, glomerular basement membrane.Demographic data, clinical and pathological parameters of anti-GBM patients with anti-P14 antibodies.
Jian-nan Li (721626), Zhao Cui (541199), Xiao-yu Jia (5663035), Shui-yi Hu (5663038), Ming-hui Zhao (3926921)   +4 more
core   +1 more source

Co-injection of anti-HS antibodies increases fibrin deposition 1 day after induction of anti-GBM glomerulonephritis.

, 2021
Glomerular fibrin deposition after (A) 1 day and (B) 4 days of anti-GBM IgG-induced glomerulonephritis, analyzed by immunofluorescence staining and scored semi-quantitatively from 0–10 based on the percentage of glomeruli with positive staining ...
Toin H. van Kuppevelt (10013111), Nathalie J. H. G. Passmann (11873757), Markus A. Loeven (3368984), Jasper J. van Gemst (3368987), Bart Smeets (170582), Johan van der Vlag (45996), Jo H. Berden (11873763), Ton J. Rabelink (8695392), Angelique L. W. M. M. Rops (11873760)   +8 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Membranous Glomerulonephritis With Crescents

Kidney International Reports, 2019
Introduction: Membranous glomerulonephritis (MGN) is rarely associated with necrotizing and crescentic glomerulonephritis (NCGN). Methods: We report the clinical and pathologic findings in 15 patients with MGN and NCGN associated with anti-neutrophil ...
Aikaterini Nikolopoulou, Isabel Huang-Doran, Stephen P. McAdoo, Megan E. Griffith, H. Terence Cook, Charles D. Pusey   +5 more
doaj   +1 more source

Pulmonary Hemorrhage and Crescentic Glomerulonephritis in a Patient with Seropositive Anti-Glomerular Basement Membrane Disease and Anti-Neutrophil Cytoplasmic Antibodies

Acta Clinica Croatica, 2022
Anti-glomerular basement membrane (anti-GBM) disease is an acute and life-threatening systemic autoimmune disorder. The coexistence of circulating anti-neutrophil cytoplasmic antibodies (ANCA) and anti-GBM disease, the so-called double-positive disease
Katherina Bernadette Sreter, Draško Pavlović, Monika Tomić, Petar Šenjug, Danica Galešić Ljubanović   +4 more
doaj   +1 more source

Host Factors Determine Anti-GM1 Response Following Oral Challenge of Chickens with Guillain-Barre Syndrome Derived Campylobacter jejuni Strain GB11 [PDF]

, 2010
Background: Anti-ganglioside antibodies with a pathogenic potential are present in C. jejuni-associated Guillain-Barre syndrome (GBS) patients and are probably induced by molecular mimicry.
Dijkstra, J.R. (Jeroen), LS Klinisch Onderzoek Wagenaar, Endtz, Hubert Ph, Ang, CW (Wim), Hubert Ph Endtz, Wagenaar, J.A., Jeurissen, Suzan H M, de Klerk, M.A., Jacobs Bart C., van Doorn, Pieter; id_orcid, Endtz Hubert Ph., Jacobs, B.C. (Bart), Endtz, Hubert, Klerk, M.A. de, Bart C Jacobs, van Doorn Pieter A., Dijkstra Jeroen R., Klerk, M.A., de, Jeurissen, P.P.T. (Patrick), Wagenaar Jaap A., de Klerk, MA, Ang, C.W., Jeurissen, SHM, Doorn, P.A., Marcel A de Klerk, Wagenaar, J.A. (Jaap), Endtz, H.P., Doorn, P.A. (Pieter) van, Doorn, P.A. van, Jacobs, B.C., Ang C. Wim, de Klerk Marcel A., Suzan H M Jeurissen, Dijkstra, JR, van Doorn, P.A., Dijkstra, J.R., Jaap A Wagenaar, Ang, C Wim, Dijkstra, Jeroen R, Wagenaar, JA, Jacobs, Bart C, Jeurissen, S.H.M., C Wim Ang, Jeroen R Dijkstra, Endtz, H.P. (Hubert), Wagenaar, Jaap A, de Klerk, Marcel A, Pieter A van Doorn, Ang, C.W. (Wim), van Doorn, Pieter A, Jeurissen Suzan H. M.   +50 more
core   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source