Results 61 to 70 of about 197,173 (246)

Recurrence of Goodpasture syndrome without circulating anti-glomerular basement membrane antibodies after kidney transplant, a case report

BMC Nephrology, 2019
Background Goodpasture Syndrome (GS) is an autoimmune disease caused by the development of auto-antibodies against the Glomerular Basement Membrane (GBM).
V. Thibaud, N. Rioux-Leclercq, C. Vigneau, S. Morice   +3 more
doaj   +1 more source

Pauci Antibody Anti-GBM Nephritis: A Case Report

Journal of Nephrology & Therapeutics, 2016
Anti-glomerular basement membrane (GBM) disease is characterized by autoantibodies directed against the anti-GBM antigen, which is part of the non-collagenous domain of the alpha 3(IV) collagen chain. These antibodies bind to the GBM and most patients show rapid progressive form of glomerulonephritis.
Upma Narain, Arvind Gupta
openaire   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

An Unusual Presentation of Myeloperoxidase-Associated Glomerulonephritis and Suspected IgA-Mediated Anti-Glomerular Basement Membrane Disease: A Case Report

Case Reports in Nephrology and Dialysis
Introduction: Anti-glomerular basement membrane (GBM) disease is a rare cause of glomerulonephritis usually mediated by IgG antibodies and is associated with ANCA-associated glomerulonephritis in up to 50% of cases.
Ciaran Twomey Brenner, Sujit Saha, Kate Bramham, Katie Vinen, Catherine Horsfield, Eirini Lioudaki   +5 more
doaj   +1 more source

Rapidly Progressive Glomerulonephritis with Delayed Appearance of Anti-Glomerular Basement Membrane Antibody Successfully Treated with Multiple Courses of Steroid Pulse Therapy

Case Reports in Nephrology and Dialysis, 2019
Patients with anti-glomerular basement membrane (GBM) antibody glomerulonephritis typically exhibit rapidly progressive glomerulonephritis (RPGN). The renal outcome as well as the prognosis of this disease is worse than other forms of RPGN such as those ...
Satoshi Toyota, Masahiro Eriguchi, Shoko Hasegawa, Kenji Ueki, Yuta Matsukuma, Akihiro Tsuchimoto, Kiichiro Fujisaki, Kumiko Torisu, Kazuhiko Tsuruya, Toshiaki Nakano, Takanari Kitazono   +10 more
doaj   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Antibody-Negative Relapse of Goodpasture Syndrome with Pulmonary Hemorrhage

Case Reports in Medicine, 2019
Goodpasture syndrome is a rare autoimmune disease comprising antiglomerular basement membrane (anti-GBM) crescentic glomerulonephritis and pulmonary capillaritis with circulating anti-GBM antibodies.
Charlene L. Rohm, Sara Acree, Aseem Shrivastava, Asif A. Saberi, Louis Lovett   +4 more
doaj   +1 more source

Sequential development of ANCA‐associated vasculitis and anti‐GBM disease: A report of two cases

Clinical Case Reports, 2021
In case of AAV with kidney involvement, physicians should explore anti‐GBM antibodies and be aware of the possible sequential development of AAV, especially with MPO‐ANCA, and anti‐GBM glomerulonephritis.
Camille Le Moine, Noémie Jourde‐Chiche, Delphine Kemlin, Benjamin Terrier, Frédéric Vandergheynst   +4 more
doaj   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Of mice and men: Murine models of anti-GBM antibody nephritis [PDF]

Kidney International, 2002
The autoimmune response to renal antigens is a significant cause of progressive glomerulonephritis and end-stage renal disease, leading to dialysis or kidney transplantation. A prominent target of renal immune injury is type IV collagen, a major constituent of the glomerular basement membrane (GBM).
Borza, Dorin-Bogdan, Hudson, Billy G.
openaire   +1 more source