Results 91 to 100 of about 22,513 (170)

The Src‐Family Kinases Hck, Fgr and Lyn Drive Immune Complex‐Mediated Glomerulonephritis Through the Syk Tyrosine Kinase

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
The study aimed to test the role of three Src‐family kinases, Hck, Fgr, and Lyn in immune complex glomerulonephritis. Hck, Fgr, and Lyn were overexpressed in human lupus nephritis and mouse nephrotoxic nephritis. Combined genetic deficiency of the three kinases practically completely protected mice from nephrotoxic nephritis.
Lukács S. Lesinszki, Dorottya Deli, Lili K. Boldizsár, Áron Pánczél, Attila Fintha, Michael G. Robson, Attila Mócsai   +6 more
wiley   +1 more source

Applications of Bioinorganic Nano‐Based Delivery Systems—Diagnostics and Therapeutics

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Nanotechnology has emerged as a promising avenue for producing nanomedicines as alternatives to conventional drugs. Many organic nanoparticles, such as liposomes used in formulations like Doxil, Onivyde, and Marqibo, are approved by the Food and Drug Administration (FDA) and instrumental in treating various types of cancers.
Frank Ssengooba, Jubilee Andrew, Donald Fernandes   +2 more
wiley   +1 more source

The ELAVL1‐PLAUR‐suPAR Axis Exacerbates Diabetic Nephropathy by Promoting Podocyte Injury and Inflammation

Journal of Diabetes, Volume 18, Issue 8, August 2026.
This study identifies a novel pathogenic pathway in DN wherein hyperglycemia‐induced ELAVL1 upregulates PLAUR expression and promotes suPAR release from podocytes, leading to renal inflammation and injury. ABSTRACT Background Diabetic nephropathy (DN) is a leading cause of end‐stage renal disease.
DanDan Xu, Liang Xu, LinLin Li
wiley   +1 more source

An Exceptional Case of Crohn-Associated IgA-Mediated Goodpasture Disease

Kidney Medicine
Anti-glomerular basement membrane (anti-GBM) disease is typically mediated by IgG autoantibodies and presents with pulmonary hemorrhage and rapidly progressive glomerulonephritis, classically referred to as Goodpasture disease.
Rebecca Ryan, Thomas Fairhead, Sophie Seager, Mona Jain, Rauri Clark   +4 more
doaj   +1 more source

Down‐Regulation of TFEB With Defective Autophagy in the Susceptibility of Aging Kidneys to Septic Acute Kidney Injury

Aging Cell, Volume 25, Issue 8, August 2026.
Aging is associated with impaired TFEB‐dependent autophagy in renal proximal tubular epithelial cells, leading to increased susceptibility to LPS‐induced injury and inflammation. Restoration of autophagy through TFEB activation or Tat–Beclin 1 treatment partially rescues autophagic function and confers protection against elderly sepsis‐associated acute
Yu Xiang, Ying Fu, Zhiwen Liu, Yu Han, Wenwen Wu, Juan Cai, Dongshan Zhang, Zheng Dong   +7 more
wiley   +1 more source

Goodpasture's syndrome with positive C-ANCA and normal renal function: A case report

Journal of Medical Case Reports, 2008
Introduction Goodpasture's syndrome consists of a triad of pulmonary hemorrhage, rapidly progressive glomerulonephritis and anti-glomerular basement membrane (anti-GBM) antibodies, either in circulation or fixed to the kidney.
Ramaswami Arunachalam, Kandaswamy Thiraviyam, Rajendran Tholappan, Aung Hla, Jacob Chakko K, Zinna Haji Shaukat, Telesinge Pemasiri   +6 more
doaj   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, Volume 183, Issue 16, Page 5082-5101, August 2026.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Anti-Glomerular Basement Membrane Disease With Thrombotic Thrombocytopenic Purpura

Case Reports in Clinical Practice, 2019
We report a 25-year-old man who was initially presented with Rapidly Progressive Glomerulonephritis (RPGN) in Shahid Modarress Hospital, Tehran, Iran.
Amirhesam Alirezaei, Mahmood Bakhtiyari, Elham Zare   +2 more
doaj  

IgA mediated anti-glomerular basement membrane disease with associated circulating anti-neutrophil cytoplasm antibodies [PDF]

Journal of Nephropathology
Anti-glomerular basement membrane (anti-GBM) disease is an aggressive small vessel vasculitis usually mediated by IgG autoantibodies. We describe the case of a 73-year-old male with rapidly progressive renal failure that was diagnosed with IgA mediated ...
Patricia Alves, Mário Góis, Tiago Pereira, Dulce Carvalho, Fernando Nolasco   +4 more
doaj   +1 more source

Fn14 signalling participates in pristane‐induced murine lupus through exacerbating oxidative stress

British Journal of Pharmacology, Volume 183, Issue 16, Page 5102-5119, August 2026.
Background and Purpose Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by oxidative stress and immune dysregulation. Fibroblast growth factor‐inducible 14 (Fn14) has been implicated in tissue injury, but its specific role in SLE pathogenesis remains unclear.
Zhu Yan, Rongfang Feng, Mai Luo, Yaqi Wang, Min Gao, Qin Chen, Yufei Zhang, Yale Liu, Yumin Xia   +8 more
wiley   +1 more source