Results 81 to 90 of about 7,623,830 (208)

ANTI-GLOMERULAR BASEMENT MEMBRANE ANTIBODY DISEASE AND ITS OUTCOME [PDF]

, 2019
Anti-glomerular basement membrane (anti-GBM) disease is an aggressive autoimmune disease which affects glomerular capillaries, characterized by glomerular fibrinoid necrosis and crescent formation with or without pulmonary hemorrhage. Patients presenting
Dr. M. Edwin Fernando, Dr. B. Karthikeyan   +1 more
core  

Antimitochondrial autoantibodies in anti-glomerular basement membrane disease

Clinical and Experimental Immunology, 1993
SUMMARYAnti-glomerular basement membrane (GBM) disease is characterized by the production of an autoantibody with very restricted specificity, with no evidence of polyclonal B cell activation. It was therefore surprising to find that in a solid-phase ELISA a proportion of anti-GBM sera showed significant binding to pyruvate dehydrogenase (PDH), a ...
J B, Marriott, D B, Oliveira
openaire   +3 more sources

Astragaloside IV Restores Autophagy and Inhibits Apoptosis for Podocyte Protection in Diabetic Nephropathy by Inhibiting Notch1 Signaling via SIRT6‐Mediated Deacetylation

Phytotherapy Research, EarlyView.
AS‐IV binds to SIRT6 and promotes H3K9 deacetylation at the Notch1 promoter, inhibiting gene transcription (Created with BioGDP.com). ABSTRACT Astragaloside IV (AS‐IV) has demonstrated efficacy in ameliorating proteinuria and attenuating renal tubular damage in preclinical diabetic nephropathy (DN) models.
Qiyu Yue, Chen Yong, Xinran Wang, Yang Shu, Min Yao, Yongfei Yu, Yubai Xue, Rong Deng, Tianlu Chu, Weiwei Tao, Min Zhao, Enchao Zhou   +11 more
wiley   +1 more source

The role of cytosolic RNA and DNA recognition in systemic autoimmunity and immune complex glomerulonephritis [PDF]

, 2010
Non-CpG-DNA and 3P-RNA activated mesangial cells to produce inflammatory cytokines and type 1 interferons in TLR-independent manner. Both ligands induced similar gene expression patterns in mesangial cells.
Ramanjaneyulu, Allam
core   +1 more source

Multiple occurrences of membranous nephropathy complicated with anti-glomerular basement membrane antibody and anti-neutrophil cytoplasm antibody double-negative crescentic formation since the COVID-19 pandemic: A case series

Journal of International Medical Research
There has been an unusual increase in the incidence of anti-glomerular basement membrane disease, anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis, and double-positive cases since the coronavirus disease 2019 (COVID-19) pandemic.
Shuang Yuan, Chao Li, ZhiBo Guo, Guang Yang, LiHong Zhang, Tao Wang   +5 more
doaj   +1 more source

Difficulties in Goodpasture's syndrome diagnosing [PDF]

Терапевтический архив, 2019
The article analyzes the diagnosis and treatment of anti-GBM antibody disease (Goodpasture's syndrome) - a rare, severe progressive disease, associated with anti-glomerular basement membrane antibody-induced pulmonary hemorrhage and glomerulonephritis ...
V I Podzolkov, G K Makhnach, T I Ishina, A B Ponomarev, I D Medvedev   +4 more
doaj   +1 more source

Deficiency of high‐molecular‐weight von Willebrand factor mitigates thrombo‐complement injury in an LPS‐induced TMA‐like mouse model

VIEW, EarlyView.
Reduction of high‐molecular‐weight von Willebrand factor disrupts the platelet–complement amplification loop, attenuating microvascular thrombosis, complement deposition, endothelial injury, and organ damage in complement‐mediated thrombotic microangiopathy.
Yang Li, Chihao Zhang, Xiaoqian Xu, Sicong Wang, Xiaofan Hu, Junjie Yao, Xi Wu, Difeng Zhu, Qian Liang, Yeling Lu, Yu Liu, Guanqun Xu, Jiakuan Zhou, Qiulan Ding, Wenman Wu, Ya Li, Jing Dai, Xuefeng Wang   +17 more
wiley   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Clinical, genetic and molecular aspects of membranous nephropathy [PDF]

, 2011
Membranous Nephropathy (MN) is one of the leading causes of end-stage renal disease (ESRD). MN is an autoimmune disease in which autoantibodies target antigens at the level of the glomerular basement membrane.
Stanescu, H.C.
core  

The time-dependent rearrangement of the epithelial basement membrane in human skin wounds [PDF]

, 1992
In 62 human skin wounds (surgical wounds, stab wounds and lacerations after surgical treatment) we analyzed the immunohistochemical localization of collagen IV in the epithelial basement membrane.
Penning, R., Eisenmenger, Wolfgang, Nerlich, A., Tübel, J., Wilske, J., Betz, P., Wiest, I.   +6 more
core   +1 more source