Results 81 to 90 of about 24,523 (202)

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Multiple occurrences of membranous nephropathy complicated with anti-glomerular basement membrane antibody and anti-neutrophil cytoplasm antibody double-negative crescentic formation since the COVID-19 pandemic: A case series

Journal of International Medical Research
There has been an unusual increase in the incidence of anti-glomerular basement membrane disease, anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis, and double-positive cases since the coronavirus disease 2019 (COVID-19) pandemic.
Shuang Yuan, Chao Li, ZhiBo Guo, Guang Yang, LiHong Zhang, Tao Wang   +5 more
doaj   +1 more source

Susceptibility to anti-glomerular basement membrane disease is strongly associated with HLA-DRB1 genes

, 1997
Susceptibility to anti-glomerular basement membrane disease is strongly associated with HLA-DRB1 genes. Anti-glomerular basement membrane (anti-GBM) disease is caused by autoimmunity to a component of the glomerular basement membrane.
Vaughan, Robert W., Rees, Andrew J., Margaret Fisher, Fisher, Margaret, Robert W. Vaughan, Pusey, Charles D., Andrew J. Rees, Charles D. Pusey   +7 more
core   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Systemic Vasculitides: Current Status and Perspectives

, 2016
Anti-glomerular basement membrane disease is a severe autoimmune disease caused by autoantibodies against epitopes on alpha 3 chains of type IV collagen, found in the alveolar and glomerular basement membrane.
Vito Racanelli, Michele Rossini, Annamaria Di Palma, Francesco Dammacco, Loreto Gesualdo   +4 more
core   +1 more source

Glomerular plasmalemma vesicle‐associated protein‐1 as an endothelial remodelling marker complementing C4d in chronic active antibody‐mediated rejection

Histopathology, EarlyView.
Glomerular plasmalemma vesicle‐associated protein‐1 (PV‐1/PLVAP) identifies dynamic endothelial remodelling in chronic active antibody‐mediated rejection (caABMR), complementing glomerular C4d, which reflects a static footprint of complement activation. Combined assessment of PV‐1 and C4d captures complementary dimensions of microvascular pathology and
Yuto Igarashi, Mayu Shimokawa, Kunio Kawanishi, Toshihito Hirai, Hiroshi Seino, Tomokazu Shimizu, Hideki Ishida, Toshio Takagi   +7 more
wiley   +1 more source

Clinical and immunologic characteristics of Japanese patients with anti-glomerular basement membrane disease: case reports and literature review

Renal Replacement Therapy, 2021
Background Clinical studies of anti-glomerular basement membrane (GBM) disease were limited because of the low incidence. We aimed to report the characteristics, treatments, and outcomes of patients with anti-GBM disease at a tertiary reference medical ...
Yoshinosuke Shimamura, Takuto Maeda, Koki Abe, Yayoi Ogawa, Hideki Takizawa   +4 more
doaj   +1 more source

Cell-mediated autoimmunity and HLA in anti-glomerular basement membrane disease

, 2023
Anti-glomerular basement membrane (anti-GBM) disease arises when the immune system attacks a protein called α3(IV)NC1, found in small blood vessels in kidneys and lungs.
KATE JOANNA ROBSON (17381941)
core   +1 more source

Clinical implications of imlifidase interference in antibody screening and transfusion management

Transfusion, EarlyView.
Abstract Background Imlifidase has received conditional approval from the EMA for desensitizing deceased donor kidney transplant recipients. It works by cleaving IgG into F(ab′)2 and Fc fragments, thereby reducing the risk of antibody‐mediated rejection. However, its impact on diagnostic assays remains understudied. Case Report We present the case of a
Zgjim Osmani, Aiko P. J. de Vries, Arjan Albersen   +2 more
wiley   +1 more source

One case of anti-glomerular basement membrane disease with serum circulating antibodies tested by ELISA to be negative

Linchuang shenzangbing zazhi, 2020
病例资料患者,男,38岁,因"痰中带血1个月"于2018年7月12日入院。入院前1个月,患者无明显诱因出现暗红色血痰,量少,咳2～3口,不伴有发热、胸闷、气紧,于2018年6月7日到广元市人民医院门诊就诊,查胸部CT示双肺多发渗出灶,未予以处理。此后患者未再出现痰中带血 ...
HAO Yu, QIN Wei
doaj