Results 71 to 80 of about 24,523 (202)

Anti-glomerular Basement Membrane Glomerulonephritis: A Study in Real Life

, 2022
INTRODUCTION: Anti-glomerular basement membrane (anti-GBM) disease is a severe entity with few therapeutic options including plasma exchange and immunosuppressive agents.
Shabaka, Amir, Cazorla, Juan M., Cazorla, Juan M, Espinosa, Mario, Soler, María J., Huerta, Ana, Calle, Leonardo, Afonso, Sara, Romera, Ana, Barroso, Sergio, Sierra, Milagros, Fernández, Saulo J., Mascarós, Victoria, Rabasco, Cristina, Spanish Group for the Study of Glomerular Diseases (GLOSEN), López-Rubio, Esperanza, Canllavi, Elisabeth, Soler, Maria J, Sánchez-Agesta, Marina, Domínguez-Torres, Patricia, Moreno-Ramírez, Manuela, Coca, Armando, Fernandez, Saulo J   +22 more
core   +1 more source

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

Recurrent anti-GBM disease with pulmonary artery aneurysms

JRSM Open, 2016
We present the first known case of pulmonary artery aneurysms as a feature of Recurrent Anti-Glomerular Basement Membrane disease.
John Dixon, Hannah Wilkinson, Kamran Iqbal, Virginia Quan   +3 more
doaj   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Fn14 signalling participates in pristane‐induced murine lupus through exacerbating oxidative stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by oxidative stress and immune dysregulation. Fibroblast growth factor‐inducible 14 (Fn14) has been implicated in tissue injury, but its specific role in SLE pathogenesis remains unclear.
Zhu Yan, Rongfang Feng, Mai Luo, Yaqi Wang, Min Gao, Qin Chen, Yufei Zhang, Yale Liu, Yumin Xia   +8 more
wiley   +1 more source

Anti–Glomerular Basement Membrane Disease after Alemtuzumab

New England Journal of Medicine, 2008
To the Editor: Alemtuzumab (Campath-1H) is a humanized anti-CD52 monoclonal antibody, the administration of which causes profound B- and T-lymphocyte depletion. It is licensed for use in the treatment of chronic lymphocytic leukemia, and it is increasingly used in the treatment of autoimmune diseases (particularly multiple sclerosis) and as an ...
Clatworthy, MR, Wallin, E, Jayne, DR
openaire   +2 more sources

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Spatial and Temporal Clustering of Anti-Glomerular Basement Membrane Disease [PDF]

Clinical Journal of the American Society of Nephrology, 2016
Background and objectives An environmental trigger has been proposed as an inciting factor in the development of anti-GBM disease. This multicenter, observational study sought to define the national incidence of anti-GBM disease during an 11-year period (2003–2014) in Ireland, investigate clustering of cases in time and space ...
Mark, Canney, Paul V, O'Hara, Caitriona M, McEvoy, Samar, Medani, Dervla M, Connaughton, Ahad A, Abdalla, Ross, Doyle, Austin G, Stack, Conall M, O'Seaghdha, Michael R, Clarkson, Matthew D, Griffin, John, Holian, Anthony M, Dorman, Aileen, Niland, Mary, Keogan, Eleanor M, Wallace, Niall P, Conlon, Cathal, Walsh, Alan, Kelly, Mark A, Little   +19 more
openaire   +3 more sources

Difficulties in Goodpasture's syndrome diagnosing [PDF]

Терапевтический архив, 2019
The article analyzes the diagnosis and treatment of anti-GBM antibody disease (Goodpasture's syndrome) - a rare, severe progressive disease, associated with anti-glomerular basement membrane antibody-induced pulmonary hemorrhage and glomerulonephritis ...
V I Podzolkov, G K Makhnach, T I Ishina, A B Ponomarev, I D Medvedev   +4 more
doaj   +1 more source