Results 61 to 70 of about 7,623,830 (208)

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Murine models of renal disease: Possibilities and problems in studies using mutant mice [PDF]

, 2000
The elucidation of the pathogenesis of human renal disease at the molecular level has been facilitated by the growing field of gene targeting and the development of mouse strains with single-gene deletions - the `knock-out' mice. Experimental nephrology,
Anders, Hans-Joachim, Schlöndorff, Detlef   +1 more
core   +1 more source

Susceptibility to anti-glomerular basement membrane disease is strongly associated with HLA-DRB1 genes [PDF]

, 1997
Susceptibility to anti-glomerular basement membrane disease is strongly associated with HLA-DRB1 genes. Anti-glomerular basement membrane (anti-GBM) disease is caused by autoimmunity to a component of the glomerular basement membrane.
Vaughan, Robert W., Rees, Andrew J., Margaret Fisher, Fisher, Margaret, Robert W. Vaughan, Pusey, Charles D., Andrew J. Rees, Charles D. Pusey   +7 more
core   +1 more source

Temporal Clustering of Antiglomerular Basement Membrane Disease in COVID-19 Pandemic: A Case Series

International Journal of Nephrology and Renovascular Disease, 2021
Rakesh Sebastian, Jegan Arunachalam, Manorajan Rajendran Department of Nephrology, Government Rajaji Hospital, Madurai Medical College, Madurai, Tamil Nadu, IndiaCorrespondence: Jegan ArunachalamDepartment of Nephrology, Government Rajaji Hospital ...
Sebastian R, Arunachalam J, Rajendran M
doaj  

Baseline podocyte‐associated state and persistent cell–matrix transcriptional programs are associated with BALB/c substrain differences in adriamycin nephropathy

Animal Models and Experimental Medicine, EarlyView.
Two closely related BALB/c substrains exhibit different early responses to adriamycin (ADR)‐induced nephropathy. BALB/cByJcl mice showed lower baseline WT1‐positive nuclei counts and NPHS1 immunoreactivity than BALB/cAJcl mice, together with extracellular matrix and integrin programs that were enriched at baseline and persisted at Day 5.
Ryuya Nakagawa, Masaki Watanabe, Koyuki Kawamoto, Momoka Hiratsuka, Takeru Sasaki, Nobuya Sasaki   +5 more
wiley   +1 more source

A case of aggressive atypical anti-GBM disease complicated by CMV pneumonitis

BMC Nephrology, 2019
Background Anti-glomerular basement membrane (anti-GBM) disease is characterized by circulating IgG glomerular basement membrane antibodies and is clinically expressed as a rapidly progressive crescentic glomerulonephritis (GN), with 30–60% of patients ...
Barbora Sporinova, Susanna A. McRae, Daniel A. Muruve, Marvin J. Fritzler, Samih H. Nasr, Alex C. Chin, Hallgrimur Benediktsson   +6 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Glomerular hematuria:an atypical presentation of anti-glomerular basement membrane nephritis [PDF]

, 2022
BACKGROUND: Urologic diseases can cause hematuria, but dysmorphic erythrocytes directs to a glomerular disease. The latter might occur isolated or in the presence of systemic complaints, proteinuria or kidney failure.
Blok, Bastiaan A, Meijer, Esther, Remmelts, Hilde H F, Franssen, Casper; id_orcid, Balder, Jan-Willem, Franssen, Casper, Luik, Peter T   +6 more
core   +4 more sources

Epigenetically Regulated NOX4/NRF2 Axis Mediates PM2.5‐Induced Ferroptosis and Inflammatory Response in Membranous Nephropathy

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aims to explore the involvement and mechanism of ferroptosis in particulate matter 2.5 (PM2.5)–induced membranous nephropathy (MN) progression. A cationic bovine serum albumin (cBSA)–induced mouse model of MN was established, followed by PM2.5 exposure.
Yanhong Gao, Yinfeng Guo, Shaoyan Xu, Min Zhang, Yanxia Rui, Shujun Pan, Changhua Zhou, Jianxiang Chen, Henglan Wu   +8 more
wiley   +1 more source