Results 61 to 70 of about 33,810 (217)

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Anti-glomerular basement membrane disease: A clinicomorphological study of 16 cases

Indian Journal of Pathology and Microbiology, 2020
Introduction: Antiglomerular basement membrane disease manifests as rapidly progressive glomerulonephritis and alveolar hemorrhage. It encompasses 10–15% of crescentic glomerulonephritis and is associated with poor outcome.
Srinivasrao Vavilapalli, Nishika Madireddy, Megha S Uppin, Karthik Kalidindi, Swarnalatha Gudithi, Gangadhar Taduri, Sree Bhushan Raju   +6 more
doaj   +1 more source

Anti-glomerular basement membrane disease, ulcerative colitis, and primary sclerosing cholangitis: link or co-incidence?

, 2010
International audienceUlcerative colitis, primary sclerosing cholangitis, and anti-glomerular basement membrane disease (anti-GBM) are three rare immune diseases with incompletely under-stood pathogenic mechanisms.
Bouguen, Guillaume, Coiffier, Guillaume, Le Pogamp, Patrick, Pinçon, Emilie, Rioux-Leclercq, Nathalie, Rivalan, Joseph, Vigneau, Cecile   +6 more
core   +4 more sources

What is new in the management of rapidly progressive glomerulonephritis? [PDF]

, 2015
Rapidly progressive glomerulonephritis (RPGN) results from severe crescentic damage to glomeruli and leads to irreversible kidney failure if not diagnosed and managed in a timely fashion.
Greenhall, GHB, Salama, AD
core   +1 more source

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

Upregulation of Transglutaminase andε(γ-Glutamyl)-Lysine in the Fisher-Lewis Rat Model of Chronic Allograft Nephropathy [PDF]

, 2014
Background. Tissue transglutaminase (TG2), a cross-linking enzyme, modulates deposition of extracellular matrix protein in renal fibrosis. This study aimed to examine TG2 and its cross-link product ε(γ-glutamyl)-lysine in the Fisher-Lewis rat renal ...
Butt, Imran, Da Silva, Michelle, Haylor, John, Johnson, Timothy, Raftery, Andrew, Sanchez-Lara, Armando, Shrestha, Badri, Wagner, Bart   +7 more
core   +3 more sources

Forsythiaside A Alleviates Kidney Injury and Intestinal Epithelium Dysfunction in IgA Nephropathy by Inhibiting TLR4/NF‐κB Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT IgA nephropathy (IgAN), the most common form of glomerulonephritis, is a major and growing public health issue. It results from intestinal barrier dysfunction that leads to mesangial deposition of pathogenic galactose‐deficient IgA1 (Gd‐IgA1) and renal inflammation.
Meng‐Si Li, Kai Liu
wiley   +1 more source

Recurrent anti-GBM disease with pulmonary artery aneurysms

JRSM Open, 2016
We present the first known case of pulmonary artery aneurysms as a feature of Recurrent Anti-Glomerular Basement Membrane disease.
John Dixon, Hannah Wilkinson, Kamran Iqbal, Virginia Quan   +3 more
doaj   +1 more source

Microscopic Haematuria [PDF]

, 2005
A 30 year old man is referred for a medical check up before taking a life insurance policy. He is asymptomatic, gives no relevant history, is on no treatment and physical examination is unremarkable. Routine dip-stick analysis of a mid­stream specimen of
Vella, Mario P.
core  

Nodular glomerulosclerosis with anti-glomerular basement membrane-like glomerulonephritis; a distinct pattern of kidney injury observed in smokers [PDF]

, 2014
Background: Cigarette smoking has recently been recognized as a risk factor for developing nodular glomerulosclerosis and has also been frequently encountered in patients with anti-glomerular basement membrane (anti-GBM) disease.
Batal, Ibrahim, Bijol, Vanesa, Popham, Sandy, Reyes, Daisy B.   +3 more
core   +1 more source