Results 101 to 110 of about 22,513 (170)

A case report of atypical anti-glomerular basement membrane disease with membrane hyperplasia lesions

Shanghai Jiaotong Daxue xuebao. Yixue ban
Atypical anti-glomerular basement membrane (GBM) disease is rare, and the atypical anti-GBM disease with membrane hyperplasia lesion is even rarer. The treatment plan for it is not clear.
ZHANG Xinping, WANG Zichuang, CHEN Xiaoyong   +2 more
doaj   +1 more source

Glomerular plasmalemma vesicle‐associated protein‐1 as an endothelial remodelling marker complementing C4d in chronic active antibody‐mediated rejection

Histopathology, Volume 89, Issue 2, Page 372-382, August 2026.
Glomerular plasmalemma vesicle‐associated protein‐1 (PV‐1/PLVAP) identifies dynamic endothelial remodelling in chronic active antibody‐mediated rejection (caABMR), complementing glomerular C4d, which reflects a static footprint of complement activation. Combined assessment of PV‐1 and C4d captures complementary dimensions of microvascular pathology and
Yuto Igarashi, Mayu Shimokawa, Kunio Kawanishi, Toshihito Hirai, Hiroshi Seino, Tomokazu Shimizu, Hideki Ishida, Toshio Takagi   +7 more
wiley   +1 more source

Age‐Associated B Cells: Origins, Regulation, and Tissue‐Specific Pathogenic Contributions in Autoimmune, Metabolic, and Neurological Diseases

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Age‐associated B cells (ABCs) are a distinct B cell population characterized by coexpression of T‐bet and CD11c. First described in aged female mice and autoimmune‐prone strains, ABCs are now recognized to be associated with multiple human autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis,
Kira Rubtsova
wiley   +1 more source

Anti-glomerular basement membrane glomerulonephritis and thrombotic microangiopathy in first degree relatives; a case report

BMC Nephrology, 2012
Background Anti-glomerular basement membrane glomerulonephritis and thrombotic microangiopathy are rare diseases with no known coherence. Case Presentation A daughter and her biological mother were diagnosed with pregnancy-induced thrombotic ...
Idorn Thomas, Schejbel Lone, Rydahl Casper, Heaf James, Jølvig Karen, Bergstrøm Marie, Garred Peter, Kamper Anne-Lise   +7 more
doaj   +1 more source

Persistent Haematuria Is Associated With Reduced Kidney Survival in Primary Podocytopathies

Nephrology, Volume 31, Issue 8, August 2026.
ABSTRACT Aim Haematuria is frequently present in podocytopathies, but its significance and prognostic value are not well described. This study aimed to determine the prevalence and association between persistent haematuria and kidney survival in patients with membranous nephropathy (MN), minimal change disease (MCD) and focal segmental ...
Gabriel Ștefan, Nicoleta Petre, Adrian Zugravu, Simona Stancu   +3 more
wiley   +1 more source

Clinical implications of imlifidase interference in antibody screening and transfusion management

Transfusion, Volume 66, Issue 8, Page 1679-1685, August 2026.
Abstract Background Imlifidase has received conditional approval from the EMA for desensitizing deceased donor kidney transplant recipients. It works by cleaving IgG into F(ab′)2 and Fc fragments, thereby reducing the risk of antibody‐mediated rejection. However, its impact on diagnostic assays remains understudied. Case Report We present the case of a
Zgjim Osmani, Aiko P. J. de Vries, Arjan Albersen   +2 more
wiley   +1 more source

Atypical anti-glomerular basement membrane disease: lessons learned [PDF]

Clinical Kidney Journal, 2016
Anti-glomerular basement membrane (GBM) disease usually pursues a self-limited course, at least from the immunological perspective. In addition, circulating antibodies to cryptic, conformational epitopes within the NC1 domain of the alpha 3 chain of Type IV Collagen are commonly found at the zenith of the clinical disease.
openaire   +2 more sources

Ubiquitination‐Related Diagnostic Biomarkers for Diabetic Nephropathy: Insights From Multiomic Analysis, Drug Docking, and Experimental Validation

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
The Graphical Abstract demonstrates our research approach. Use GEO database to screen differentially expressed genes (DEGs), and weighted gene co expression network analysis (WGCNA) to identify ubiquitination related gene modules. The LASSO logistic regression and support vector machine recursive feature elimination (SVM‐RFE) algorithm is used to ...
Ting Dong, Miao Hu, Haibo Yu, Ling Zhou, Qing Qiao   +4 more
wiley   +1 more source

Anti–Glomerular Basement Membrane Disease: Recent Updates

Advances in Kidney Disease and Health
Anti-glomerular basement membrane disease is a small-vessel vasculitis involving the kidneys (∼90%) and the lungs (∼60%). Antibodies against the glomerular basement membrane are directly pathogenic in anti-glomerular basement membrane disease; however, recent research has highlighted the critical role of T cells.
Joyita Bharati, Kenar D. Jhaveri, Alan D. Salama, Louise Oni   +3 more
openaire   +2 more sources

SGLT2 Inhibition Attenuates Renal Tubular Senescence by Suppressing CTRP1‐Mediated Glucotoxic Stress in Diabetic Kidney Disease

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
Hyperglycemia upregulates CTRP1 and SGLT2 in renal tubular cells, promoting glucose influx, CTRP1‐mediated glucotoxic stress, and tubular senescence in diabetic kidney disease. In the experimental model, SGLT2 inhibition with dapagliflozin was associated with reduced glucose uptake, attenuation of tubular senescence, suppression of CTRP1‐related ...
Lina Gu, Buhui Liu, Lei Zhang, Jing Zhao, Weiming He, Hong Lang, Wei Sun   +6 more
wiley   +1 more source