Results 111 to 120 of about 7,623,830 (208)

Bronchiectasis as the Sentinel Manifestation of ANCA‐Associated Vasculitis: A Case Report and Literature Review

Respirology Case Reports, Volume 14, Issue 10, October 2026.
A 74‐year‐old woman was treated for 7 years as culture‐negative bronchiectasis before palpable purpura, haemoptysis, and acute kidney injury revealed MPO‐ANCA vasculitis with pauci‐immune crescentic glomerulonephritis. Rituximab‐based induction produced near‐complete resolution of the pulmonary consolidations and sustained clinical remission at 15 ...
Andrew Kim, Celine Vartany, Siddhanth Hegde, Kristie Lau, Lynette Tatosyan, Brannen Liang   +5 more
wiley   +1 more source

Targets of alloantibodies in Alport anti-glomerular basement membrane disease after renal transplantation [PDF]

, 1998
Targets of alloantibodies in Alport anti-glomerular basement membrane disease after renal transplantation. A minority of patients with Alport syndrome develop anti-GBM disease in their allografts after renal transplantation. Clinically, the renal disease
Gubler, Marie Claire, Turner, A. Neil, Brainwood, David, Kashtan, Clifford   +3 more
core   +1 more source

Complement in anti-glomerular basement membrane glomerulonephritis [PDF]

Anti-glomerular basement membrane glomerulonephritis (anti-GBM GN) is a rare autoimmune disease that often progresses to end-stage renal disease (ESRD).
Kai-li Shi, Pei Zhang, Chun-lin Gao, Li-li Jia, Ji-chao Sun, Feng Xu   +5 more
core   +1 more source

uPAR‐Targeting T Cell Engager Exerts Senolytic Effects in Mice and Non‐Human Primates With Serum Aminotransferase Activity as a Safety Monitor

Aging Cell, Volume 25, Issue 10, October 2026.
GFD‐CD3, a uPAR‐targeting T‐cell engager, effectively cleared senescent cells and mitigated age‐related pathologies with a favorable safety profile under transaminase‐guided monitoring. ABSTRACT Senolytic CAR‐T cells targeting uPAR induce dose‐dependent toxicities.
Jian Deng, Xiaozhu Zeng, Jing Guo, Lihong Li, Shirui Zou, Nan Liu, Shuai He, Lanzhen Yan, Qiong Wang, Yongjie Zhu, Ben Wang, Dong Yang, Longbao Lv, Xudong Zhao   +13 more
wiley   +1 more source

Anti-glomerular basement membrane antibody disease: a rare autoimmune disorder affecting the kidney and the lung.

, 2012
Anti-glomerular basement membrane antibody disease is a rare, but well characterized cause of glomerulonephritis. By definition serum anti-GBM antibody and/or a linear binding of IgG detected by direct immunofluorescence (IF) in a histological specimen ...
Lahmer, T;Heemann, U
core   +1 more source

Five‐Year Outcomes and Clinicopathological Correlations of Kidney Transplants From Deceased Donors With Diabetes

Clinical Transplantation, Volume 40, Issue 10, October 2026.
ABSTRACT Background Kidneys from deceased donors with diabetes mellitus are refused because diabetes is considered a marker of lower organ quality. We evaluated 5‐year outcomes according to donor‐recipient diabetes status and, secondarily, the prognostic value of pre‐implantation histopathological findings among accepted diabetic donor kidneys ...
Marina Colella‐Santos, Pedro Henrique Pepato, Henrique Machado de Sousa Proença, Luiz Antonio Ribeiro de Moura, José Medina‐Pestana, Renato Demarchi Foresto, Lúcio Requião‐Moura   +6 more
wiley   +1 more source

Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice [PDF]

, 2012
The strongest serological correlate for lupus nephritis is antibody to double-stranded DNA, although the mechanism by which anti-DNA antibodies initiate lupus nephritis is unresolved.
Meera R. Krishnan, Krishnan, Meera R., Marion, Tony N., Wang, Congmiao, Congmiao Wang, Tony N. Marion   +5 more
core   +1 more source

Atypical anti-glomerular basement membrane disease: lessons learned [PDF]

Clinical Kidney Journal, 2016
Anti-glomerular basement membrane (GBM) disease usually pursues a self-limited course, at least from the immunological perspective. In addition, circulating antibodies to cryptic, conformational epitopes within the NC1 domain of the alpha 3 chain of Type IV Collagen are commonly found at the zenith of the clinical disease.
openaire   +2 more sources

Targeting the miR‐224‐5p/PTEN pathway: A previously under‐characterized strategy to attenuate mesangial cell injury and predict prognosis in diabetic nephropathy

Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1744-1758, October 2026.
Serum miR‐224‐5p levels are progressively elevated in diabetic nephropathy (DN) and serve as an independent predictor of a decline in eGFR of ≥30% over 2 years. Mechanistically, miR‐224‐5p directly targets PTEN 3’‐UTR, suppressing PTEN and the activation of the AKT pathway in high‐glucose‐stimulated mesangial cells.
Yanxia Gao, Xiaohui Zhang, Peng Lu, Qiang Wang   +3 more
wiley   +1 more source

Hypertensive emergency and seizures in a 30‐year‐old man with anti–glomerular basement membrane disease

, 2020
Anti–glomerular basement membrane disease can rapidly lead to renal failure and blood pressure dysregulation. A rare complication is hypertensive encephalopathy in the form of seizures.
Joshua Mathews, Rehan Karmali, Sergio Obligado, Michael Mascola   +3 more
core   +1 more source