Lectins with Anti-HIV Activity: A Review [PDF]
Molecules, 2015 Lectins including flowering plant lectins, algal lectins, cyanobacterial lectins, actinomycete lectin, worm lectins, and the nonpeptidic lectin mimics pradimicins and benanomicins, exhibit anti-HIV activity.
Ouafae Akkouh +7 more
doaj +3 more sources
Modeling Anti-HIV-1 HSPC-Based Gene Therapy in Humanized Mice Previously Infected with HIV-1 [PDF]
Molecular Therapy: Methods & Clinical Development, 2018 Investigations of anti-HIV-1 human hematopoietic stem/progenitor cell (HSPC)-based gene therapy have been performed by HIV-1 challenge after the engraftment of gene-modified HSPCs in humanized mouse models.
Wannisa Khamaikawin +13 more
doaj +4 more sources
Polymeric Anti‐HIV Therapeutics [PDF]
Macromolecular Bioscience, 2014 AbstractThe scope of this review is to highlight the application of polymer therapeutics in an effort to curb the transmission and infection of the human immunodeficiency virus (HIV). Following a description of the HIV life cycle, the use of approved antiretroviral drugs that inhibit critical steps in the HIV infection process is highlighted.
Maarten, Danial, Harm-Anton, Klok
openaire +3 more sources
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques [PDF]
Journal of Experimental Medicine, 2014 It is widely appreciated that effective human vaccines directed against viral pathogens elicit neutralizing antibodies (NAbs). The passive transfer of anti–HIV-1 NAbs conferring sterilizing immunity to macaques has been used to determine the plasma ...
Bjorkman, Pamela J., Shingai, Masashi
core +2 more sources
Anti-HIV-1 HSPC-based gene therapy with safety kill switch to defend against and attack HIV-1 infection [PDF]
Molecular Therapy: Methods & Clinical DevelopmentHematopoietic stem/progenitor cell (HSPC)-based anti-HIV-1 gene therapy holds promise to provide life-long remission following a single treatment. Here we report a multi-pronged anti-HIV-1 HSPC-based gene therapy designed to defend against and attack HIV-
Qi Guo +7 more
doaj +2 more sources
Exploring the role of topological descriptors to predict physicochemical properties of anti-HIV drugs by using supervised machine learning algorithms [PDF]
BMC ChemistryIn order to explore the role of topological indices for predicting physio-chemical properties of anti-HIV drugs, this research uses python program-based algorithms to compute topological indices as well as machine learning algorithms.
Wakeel Ahmed +5 more
doaj +2 more sources
Investigation of genes coding for anti-HIV proteins MAP30 and MRK29 from Thai bitter melon (Momordica charantia L.) [PDF]
Pharmaceutical Sciences Asia, 2022 Thai bitter melon, or Ma-Ra-Khee-Nok, is an M. charantia L. variety that is widely cultivated in Thailand. Thai bitter melon exhibits various pharmacological activities, including antidiabetic and antiviral. Many phytochemicals are found in various parts
Paktraporn Mekloy +3 more
doaj +1 more source
Prolonged viral suppression with anti-HIV-1 antibody therapy
Nature, 2022 HIV-1 infection remains a public health problem with no cure. Anti-retroviral therapy (ART) is effective but requires lifelong drug administration owing to a stable reservoir of latent proviruses integrated into the genome of CD4+ T cells1. Immunotherapy
C. Gaebler +23 more
semanticscholar +1 more source
Plant Coumarins with Anti-HIV Activity: Isolation and Mechanisms of Action
International Journal of Molecular Sciences, 2023 This review summarizes and systematizes the literature on the anti-HIV activity of plant coumarins with emphasis on isolation and the mechanism of their antiviral action.
A. Sharapov +5 more
semanticscholar +1 more source
Prediction of the anti-HIV activities of PETT analogs as non-nucleoside HIV-1 reverse transcriptase inhibitors by linear and non-linear QSAR models [PDF]
شیمی کاربردی روز, 2015 Quantitative structure-activity relationship (QSAR) models were constructed in order to predict the anti-HIV activity of a set of phenethyl thiazole thiourea (PETT) analogs by calculated descriptors.
منصور عرب چم جنگلی +3 more
doaj +1 more source