Modeling Anti-HIV-1 HSPC-Based Gene Therapy in Humanized Mice Previously Infected with HIV-1 [PDF]
Molecular Therapy: Methods & Clinical Development, 2018 Investigations of anti-HIV-1 human hematopoietic stem/progenitor cell (HSPC)-based gene therapy have been performed by HIV-1 challenge after the engraftment of gene-modified HSPCs in humanized mouse models.
Wannisa Khamaikawin +13 more
doaj +4 more sources
Anti-HIV-1 HSPC-based gene therapy with safety kill switch to defend against and attack HIV-1 infection [PDF]
Molecular Therapy: Methods & Clinical DevelopmentHematopoietic stem/progenitor cell (HSPC)-based anti-HIV-1 gene therapy holds promise to provide life-long remission following a single treatment. Here we report a multi-pronged anti-HIV-1 HSPC-based gene therapy designed to defend against and attack HIV-
Qi Guo +7 more
doaj +2 more sources
Exploring the role of topological descriptors to predict physicochemical properties of anti-HIV drugs by using supervised machine learning algorithms [PDF]
BMC ChemistryIn order to explore the role of topological indices for predicting physio-chemical properties of anti-HIV drugs, this research uses python program-based algorithms to compute topological indices as well as machine learning algorithms.
Wakeel Ahmed +5 more
doaj +2 more sources
Investigation of genes coding for anti-HIV proteins MAP30 and MRK29 from Thai bitter melon (Momordica charantia L.) [PDF]
Pharmaceutical Sciences Asia, 2022 Thai bitter melon, or Ma-Ra-Khee-Nok, is an M. charantia L. variety that is widely cultivated in Thailand. Thai bitter melon exhibits various pharmacological activities, including antidiabetic and antiviral. Many phytochemicals are found in various parts
Paktraporn Mekloy +3 more
doaj +1 more source
Synthesis of Isatin and its derivatives containing heterocyclic compounds
Journal of the Turkish Chemical Society, Section A: Chemistry, 2021 Isatin or 1H-indole-2,3-dione or 2,3-dioxindole is an indole derivative. Isatin and its analogs are synthetically useful substances where they may be utilized for the production of a broad range of heterocyclic molecules, which are depicting a wide reach
Pratibha MİSHRA +4 more
doaj +1 more source
Prediction of the anti-HIV activities of PETT analogs as non-nucleoside HIV-1 reverse transcriptase inhibitors by linear and non-linear QSAR models [PDF]
شیمی کاربردی روز, 2015 Quantitative structure-activity relationship (QSAR) models were constructed in order to predict the anti-HIV activity of a set of phenethyl thiazole thiourea (PETT) analogs by calculated descriptors.
منصور عرب چم جنگلی +3 more
doaj +1 more source
Ganoderma: The mushroom of immortality [PDF]
Microbial Biosystems Journal, 2019 Ganoderma is the genus from order Aphyllophorales with more than 300 species. Ganoderma contains various compound that showed many biological activities e.g.
Shimaa El Mansy
doaj +1 more source
HIV Seropositivity in Patients Admitted to Our Hospital: Six Year Evaluation
Düzce Tıp Fakültesi Dergisi, 2021 Aim: Detecting human immunodeficiency virus (HIV)-infected individuals is very important in terms of quality of patients’ lives. However, it should be kept in mind that there may be false positives and tests must be confirmed. In this study, it was aimed
İlknur Esen Yıldız, İlkay Bahçeci
doaj +1 more source
Feeding Eggs from Hens Immunized with Specific KLH-Conjugated HIV Peptide Candidate Vaccines to Chicks Induces Specific Anti-HIV gp120 and gp41 Antibodies that Neutralize the Original HIV Antigens [PDF]
Vaccine Research, 2020 Introduction: Isolation of antibodies from the egg yolk of chickens is of particular interest as a source of specific antibodies for oral administration to prevent infections and use them as immunodiagnostic reagents.
Justiz Vaillant +3 more
doaj +1 more source
Polymeric Anti‐HIV Therapeutics [PDF]
Macromolecular Bioscience, 2014 AbstractThe scope of this review is to highlight the application of polymer therapeutics in an effort to curb the transmission and infection of the human immunodeficiency virus (HIV). Following a description of the HIV life cycle, the use of approved antiretroviral drugs that inhibit critical steps in the HIV infection process is highlighted.
Maarten, Danial, Harm-Anton, Klok
openaire +2 more sources