Results 111 to 120 of about 3,688,101 (379)

Combination anti-HIV antibodies provide sustained virological suppression

Nature, 2022
M. Sneller, J. Blazkova, J. Justement, V. Shi, Brooke D Kennedy, Kathleen R. Gittens, Jekaterina Tolstenko, Genevieve McCormack, Emily J. Whitehead, Rachel F. Schneck, M. Proschan, E. Benko, C. Kovacs, Cihan Oguz, M. Seaman, M. Caskey, M. Nussenzweig, A. Fauci, S. Moir, T. Chun   +19 more
semanticscholar   +1 more source

Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs

Beilstein Journal of Organic Chemistry, 2014
The therapeutic approach for the treatment of HIV infection is based on the highly active antiretroviral therapy (HAART), a cocktail of antiretroviral drugs. Notwithstanding HAART has shown different drawbacks like toxic side effects and the emergence of
F. Chiodo, M. Marradi, Javier Calvo, E. Yuste, S. Penadés   +4 more
semanticscholar   +1 more source

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

Advanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao, Xu‐Ying Pei, Yuan‐Yuan Zhang, Juan Xie, Jing‐Wei Tu, Zhuo‐Jun Liu, Yi‐Yang Ding, Chen‐Hua Yan, Yu‐Hong Chen, Yu Wang, Lan‐Ping Xu, Xiao‐Hui Zhang, Xiao‐Jun Huang, Xiang‐Yu Zhao   +13 more
wiley   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors

Bioinorganic Chemistry and Applications, 2006
HIV/AIDS pandemics is a serious threat to health and development of mankind, and searching for effective anti-HIV agents remains actual. Considerable progress has been made in recent years in the field of drug development against HIV.
I. Kostova, S. Raleva, P. Genova, R. Argirova   +3 more
doaj   +2 more sources

Hepatitis-C and Hepatitis-B Co-Infections in Patients with Human Immunodeficiency Virus in Tehran, Iran [PDF]

Acta Medica Iranica, 2011
We carried out a study to determine the seroprevalence of HBV and HCV infections in HIV positive patients at a main referral center for HIV/AIDS in Iran.
SeyedAhmad SeyedAlinaghi, Sara Jam, Farhad Mehrkhani, Fatemeh Fattahi, Duman Sabzvari, Zahra Kourorian, Hossain Jabbari, Minoo Mohraz   +7 more
doaj   +1 more source

Synthesis of 1,4-Disubstituted Mono and Bis-triazolocarbo-acyclonucleoside Analogues of 9-(4-Hydroxybutyl)guanine by Cu(I)-Catalyzed Click Azide-Alkyne Cycloaddition [PDF]

, 2011
A series of novel mono-1,2,3-triazole and bis-1,2,3-triazole acyclonucleoside analogues of 9-(4-hydroxybutyl)guanine was prepared via copper(I)-catalyzed 1,3-dipolar cycloaddition of N-9 propargylpurine, N-1-propargylpyrimidines/as-triazine with the ...
Engels, Joachim W., Krim, Jamal, Taourirte, Mohamed   +2 more
core   +2 more sources

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Viral immunochemical status of HBeAg, HBeAb, Anti-HIV, and Anti-HCV in hepatitis B surface antigen-seronegative anicteric malaise patients

Biomedical and Biotechnology Research Journal, 2018
Introduction: Malaise involves general discomfort, uneasiness, or pain which could indicate microbial infection or other diseases which could be as a result of immune response.
Mathew Folaranmi Olaniyan, Opeoluwa Oluwabamise Jegede   +1 more
doaj   +1 more source

Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages. [PDF]

, 1987
Primary human monocyte-derived macrophages (MDM) were shown to have diminished deoxynucleoside kinase activities compared to T lymphoblasts, and a reduced ability to phosphorylate dideoxynucleosides with anti-human immunodeficiency virus (HIV) activity ...
Carson, DA, Kornbluth, RS, Richman, DD
core