Results 101 to 110 of about 686,239 (385)

Antihuman Immunodeficiency Virus Type 1 (HIV-1) Activity of Rare Earth Metal Complexes of 4-Hydroxycoumarins in Cell Culture

Bioinorganic Chemistry and Applications, 2006
The cerium Ce(III), lanthanum La(III), and neodymium Nd(III) complexes with 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one (warfarin) (W) and 3,3′-benzylidenebis[4-hydroxycoumarin] (1) were synthesized and studied for the first time for ...
Ilia Manolov, Sevda Raleva, Petya Genova, Alexey Savov, Liliana Froloshka, Daniela Dundarova, Radka Argirova   +6 more
doaj   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein [PDF]

, 2018
In this report, we present a new benzoxazole derivative endowed with inhibitory activity against the HIV-1 nucleocapsid protein (NC). NC is a 55-residue basic protein with nucleic acid chaperone properties, which has emerged as a novel and potential ...
Botta, Maurizio, Fabris, Dan, Gamba, Elia, Gatto, Barbara, Giannini, Alessia, Kovalenko, Lesia, Mely, YVES CAMILLE RENE', Mori, Mattia, Saladini, Francesco, Sosic, Alice   +9 more
core   +3 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

A dynamic theory of fidelity networks with an application to the spread of HIV/AIDS [PDF]

We study the dynamic stability of fidelity networks, which are networks that form in a mating economy of agents of two types (say men and women), where each agent desires direct links with opposite type agents, while engaging in multiple partnerships is ...
Roberto Serrano, Roland Pongou
core  

Effectiveness of Pre‐Transplant Dual GLP‐1 Receptor Agonist and SGLT2 Inhibitor Therapy on All‐Cause Mortality in Organ Transplantation Candidates with Obesity and Type 2 Diabetes: a Target‐Trial Emulation

Advanced Science, EarlyView.
This target trial emulation in solid organ transplant candidates with obesity and type 2 diabetes evaluates whether pre‐transplant dual therapy with GLP‐1 receptor agonists plus SGLT2 inhibitors is associated with post‐transplant mortality and kidney graft outcomes compared with monotherapy or usual care, using multinational electronic health records ...
Yu‐Nan Huang, Min‐Yu Tsou, Pin‐Hung Li, Jo‐Ching Chen, Yen‐Liang Liu, Gideon Meyerowitz‐Katz, Tsung‐Hsun Tsai, Pen‐Hua Su   +7 more
wiley   +1 more source

A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter. [PDF]

, 2017
The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by ...
Ao, Ming-Tao, Fang, Mei-Juan, Gao, Xiang, Shao, Rui, Wang, Hui-Ru, Wu, Jun, Wu, Zhen, Xue, Yu-Hua, Yu, Diao, Zhou, Qiang   +9 more
core   +2 more sources

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Role of lactobacilli and lactoferrin in the mucosal cervicovaginal defense [PDF]

, 2018
Human lactoferrin is an iron-binding glycoprotein present at high concentrations in breast milk and colostrum. It is produced by many exocrine glands and widely distributed in a variety of body fluids.
Aagaard, Abramov, Agerberth, Aldunate, Alexander, Allsworth, Anahtar, Ando, Appelmelk, Aroutcheva, Ashida, Baker, Baranger, Beigi, Berlutti, Berlutti, Berlutti, Bradshaw, Bradshaw, Britigan, Brooks, Brotman, Bullen, Byrne, Caccavo, Cauci, Cherpes, Cole, Cole, Conti, Corbin, Corbishley, Cutone, Cutone, De Gregorio, Deese, Delgado-Rizo, Drannik, Elass, Ericksen, Eschenbach, Eslami, Frioni, Fritsch, Gajer, He, He, Hearps, Hedges, Hein, Hemalatha, Hickey, Hiemstra, Hill, Hill, Hudić, Hummelen, Jakobsson, Judd, Kaushic, Kelver, Klebanoff, Kohlhoff, Kościuczuk, Lamont, Larsen, Legrand, Legrand, Leitch, Maggi, Marrazzo, Martin, Martin, Mastromarino, Mastromarino, Mastromarino, Meijerink, Michieli, Moberg, Morrison, Morrison, Nardis, Ness, Niyonsaba, Olmsted, Olmsted, Omata, Ong, O’Hanlon, Paesano, Paesano, Paesano, Paesano, Paesano, Pazgier, Peipert, Peipert, Petrova, Pino, Puddu, Quayle, Rampersauda, Raulston, Ravel, Ravel, Redondo-Lopez, Reghunathan, Rizzo, Rizzo, Roberton, Rosa, Rönnqvist, Santiago, Santiago, Sarkar, Sessa, Shakibaei, Shust, Singh, Singh, Spadaro, Spear, Spurbeck, Srinivasan, Srinivasan, Stallmann, Straub, Stríz, Suzuki, Tachedjian, Teng, Teng, Teng, Tuyama, Valenti, Valenti, Valenti, Valore, Van de Wijgert, Vargas-Villavicencio, Vielfort, Vitali, Walther-António, Ward, Weinberg, Wiesenfeld, Wiesner, Wilson, Wilson, Wilson, Wira, Wira, Wira, Wira, Wu, Yamamoto, Zhou   +156 more
core   +2 more sources

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source