Results 161 to 170 of about 492,595 (235)
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Natural Products as Anti- HIV Agents
Nigerian Quarterly Journal of Hospital Medicine, 2008Acquired immunodeficiency syndrome (AIDS) is a pandemic immunodegenerative disease caused by human immunodeficiency virus (HIV). The disease is ravaging, given the number of patients infected with the disease worldwide, the high mortality rate and attendant socio-economic casualties in affected countries, mostly in Africa.
H A Coker, S A Adesegun, G O Ajayi
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Polyoxometalates and Fullerenes as Anti-HIV Agents [PDF]
, 1999 The lack of proofreading ability of HIV reverse transcriptase leads to errors and the development of drug-resistant HIV variants. This has prompted a concerted research effort to find new efficacious chemotherapies that are not cross-resistant with currently approved antiviral agents.
Craig L. Hill +3 more
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Quinobene, a new potent anti-HIV agent
Biochemical and Biophysical Research Communications, 1992A simple synthesis of the sulfonated azo dye Quinobene (3) and its derivatives, as well as the results of their evaluation in anti-HIV screening have been described. Thus, reacting the diazonium salt of 4,4'-diaminostilbene-2,2'-disulfonic acid with 8-hydroxyquinoline-5-sulfonic acid yielded the readily isolable title compound.
Ewa Gruszecka-Kowalik +2 more
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Combinatorial Synthesis of Anti-HIV Agents-A Review
Combinatorial Chemistry & High Throughput Screening, 2005Combinatorial chemistry has been well recognized as an important tool of drug discovery. An ongoing hand is to integrate the combinatorial approach with fundamentals of medicinal chemistry and rational drug design. The last five years has seen an explosion in the exploration and adoption of combinatorial techniques.
Dharmarajan Sriram +2 more
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Ribozymes as Potential Anti-HIV-1 Therapeutic Agents [PDF]
Science, 1990 Certain RNA molecules, called ribozymes, possess enzymatic, self-cleaving activity. The cleavage reaction is catalytic and no energy source is required. Ribozymes of the "hammerhead" motif were identified in plant RNA pathogens. These ribozymes possess unique secondary (and possibly tertiary) structures critical for their cleavage ability.
Edouard M. Cantin +7 more
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DNA aptamers as potential anti-HIV agents
Trends in Biochemical Sciences, 2005Guanine (G)-rich DNA sequences can adopt stable G-quadruplex structures by G-tetrad hydrogen-bonding and hydrophobic stacking. Recently, it has been shown that a DNA sequence forms an aptamer (termed 93del) and adopts a novel dimeric quadruplex folding topology in K+ solution. This aptamer exhibits anti-HIV1 integrase activity in the nanomolar range in
Ko-Hsin Chin +2 more
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New Azt Conjugates as Potent Anti-HIV Agents
Nucleosides, Nucleotides and Nucleic Acids, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Henry J. Lee, Zhengqing You
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Total Synthesis of Anti-HIV Agent Chloropeptin I
Journal of the American Chemical Society, 2003A convergent diastereo- and enantioselective total synthesis of anti-HIV agent chloropeptin I is reported. Important features of the total synthesis include: (1) the use of Ti-catalyzed cyanide addition to imines to prepare a requisite amino acid moiety, (2) the discovery of the positive effect of MeOH in the Cu-mediated biaryl ether formation to ...
Tao Liu +5 more
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Natural Products as Anti-HIV Agents
1992The publication, in 1981, of a report announcing the occurrence of a cluster of diagnoses of a rare form of pneumonia due to the microorganism Pneumocystis carinii in a group of male homosexuals in San Francisco constitutes the first notice of the advent of a new disease. It was quickly recognized, subsequent to that report, that the occurrence of this
Daniel Lednicer, Ven L. Narayanan
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6-Aminoquinolones as New Potential Anti-HIV Agents
Journal of Medicinal Chemistry, 2000A series of 6-aminoquinolone compounds were evaluated for their in vitro activity against human immunodeficiency virus type 1 (HIV-1). Compound 12a, bearing a methyl substituent at the N-1 position and a 4-(2-pyridyl)-1-piperazine moiety at the C-7 position, was the most active in inhibiting HIV-1 replication on de novo infected C8166 human ...
V. CECCHETTI +10 more
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