Results 171 to 180 of about 492,595 (235)

ChemInform Abstract: Synthesis and Anti‐HIV Activity of Arylpiperazinyl Fluoroquinolones: A New Class of Anti‐HIV Agents.

ChemInform, 1999
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tetsushi Katsube, Satoshi Kimura, Hiroto Kashiwase, Kenji Momota, Takashi Nishigaki, Toshinori Ohmine, Tomoaki Komai, Masahiko Hagihara, Tomio Kimura, Kaoru Shimada   +9 more
openaire   +3 more sources

Tetrahydrothiophene nucleosides as potential anti-HIV agents

Tetrahedron Letters, 1991
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Martin Francis Jones, Colin A. Robertson, Stewart A. Noble, Richard Storer   +3 more
openaire   +3 more sources

Iminosugar glycosylation inhibitors as anti-HIV agents

Perspectives in Drug Discovery and Design, 1993
A novel class of compounds which are potent inhibitors of the posttranslational glycan trimming enzyme α-glucosidase I have been found to display anti-HIV activity. These compounds are iminosugar analogs ofd-glucose, with the oxygen in the ring replaced by a nitrogen, and were originally isolated from plants and microorganisms, although a considerable ...
Gary S. Jacob, Martin L. Bryant
openaire   +2 more sources

Evaluation of tea polyphenols as anti-HIV agents

Bioorganic & Medicinal Chemistry Letters, 1996
Thirty-eight tea polyphenols were evaluated for their inhibitory effect against HIV replication in H9 lymphocyte cells. 8-C-Ascorbyl (−)-epigallocatechin (13) and theasinensin-D (32) demonstrated relatively potent anti-HIV activity with EC50 values of 4 and 8 μg/mL and therapeutic indexes of 9.5 and 5, respectively.
Toshihiro Nohara, L. Mark Cosentino, Gen-ichiro Nonaka, Itsuo Nishioka, Fumlo Hashimoto, Fumlo Hashimoto, Yoshiki Kashiwada, Kuo Hsiung Lee   +7 more
openaire   +2 more sources

Physicochemical Properties of Carbovir, a Potential Anti-HIV Agent

Journal of Pharmaceutical Sciences, 1990
(+-)-Carbovir [(+-)-9-[4 alpha-(hydroxymethyl)-cyclopent-2-ene-1 alpha-yl]guanine; NSC 614846] is a novel carbocyclic nucleoside analogue which has been shown to be a potent and selective inhibitor of HIV in vitro. As part of an effort to develop a parenteral formulation for subsequent clinical and toxicological evaluation of this compound, the aqueous
Chin-Yun Chiang, Bradley D. Anderson
openaire   +3 more sources

Endophytic Microbial Diversity: A New Hope for the Production of Novel Anti-tumor and Anti-HIV Agents as Future Therapeutics

Current Microbiology, 2021
Aditya Banyal, Vikram Thakur, Rahul Thakur, Pradeep Kumar   +3 more
semanticscholar   +1 more source

Marine Natural Products as Lead Anti-HIV Agents

Mini-Reviews in Medicinal Chemistry, 2003
Current anti-HIV drugs have extreme side effects and resistance to these drugs develops rapidly. The marine environment holds an unprecedented number of unusual chemical structural classes with activity against HIV. We review the literature on anti-HIV activity of marine natural products and discuss the efficacy of different structural classes.
D J, Gochfeld, K A, El Sayed, M, Yousaf, J F, Hu, P, Bartyzel, D C, Dunbar, S P, Wilkins, J K, Zjawiony, R F, Schinazi, S, Schlueter Wirtz, P M, Tharnish, M T, Hamann   +11 more
openaire   +3 more sources

Further characterization of sulfated homopolysaccharides as anti-HIV agents

Experientia, 1989
Fucoidan and dextran sulfate showed anti-HIV activities against mononuclear cells from AIDS patients, and they abrogated HIV reverse transcriptase (RT) activity by interacting with the HIV envelope in the membranes of target cells. Furthermore, they showed a synergistic effect with azidothymidine (AZT).
W. Itoh, K. Shimada, Satoshi Kimura, Isamu Sugawara, Shigeo Mori   +4 more
openaire   +3 more sources

Plant-derived Terpenoids and Analogues as Anti-HIV Agents

Current Topics in Medicinal Chemistry, 2003
The plant-derived terpenoids and analogues are reviewed with respect to their anti-HIV activity, structure-activity relationships, and mechanism of action. The active compounds include diterpenoid lactones, phenolic diterpenes, atisane and kaurane diterpenes, phorbol diterpenes, triterpene glycosides, friedelane triterpenes, taraxerane triterpenes ...
Susan L. Morris-Natschke, I-Chen Sun, Yoshiki Kashiwada, Kuo Hsiung Lee   +3 more
openaire   +3 more sources

New nordihydroguaiaretic acid derivatives as anti-HIV agents

Bioorganic & Medicinal Chemistry Letters, 2008
Reaction of nordihydroguaiaretic acid with various alkyl chloride, 1-piperidinecarbonyl chloride, methyl chloroformate, or 1,1'-carbonyldiimidazole under alkaline conditions produced the corresponding phenol ethers, carbamates and carbonates, respectively, in 67-83% yields.
Ming-Hua Hsu, Ming-Hua Hsu, Jih Ru Hwu, Ru Chih C. Huang   +3 more
openaire   +3 more sources