Results 181 to 190 of about 492,595 (235)
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Synthesis and QSAR Studies on Thiazolidinones as Anti-HIV Agents
Combinatorial Chemistry & High Throughput Screening, 2005Selected 4-thiazolidinone have been synthesized and tested as anti-HIV activity. The results of the in vitro tests showed that one of the compounds, 5, inhibited the enzyme at 0.204 microM concentration with minimal toxicity to MT-4 cell. Furthermore, the QSAR studies indicated the role of PMIZ, Ovality and Total energy content of the compounds in ...
Ravindra K. Rawal +4 more
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Researchers Explore New Anti-HIV Agents
JAMA, 2002SEATTLE—While antiretroviral drugs have done much to extend the lives of people infected with HIV, severe adverse effects and rising levels of drug resistance can limit their usefulness and are driving efforts to develop new antiHIV medications. Building on knowledge of HIV gleaned from laboratory studies of the virus, researchers are developing and ...
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Functional Roles of Azoles Motif in Anti-HIV Agents
Current Medicinal Chemistry, 2011Currently, there has been considerable interest in the discovery of original molecules with broad-spectrum anti-HIV activity and favourable pharmacokinetic profiles, to be used as an alternative to the approved anti-HIV/AIDS drugs, should they fail as therapeutics.
Dongyue Li +4 more
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Transport, metabolism and elimination mechanisms of anti-HIV agents
Advanced Drug Delivery Reviews, 1999Currently available anti-HIV drugs can be classified into three categories: nucleoside analogue reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, and protease inhibitors. Knowledge of these anti-HIV drugs in various physiological or pharmacokinetic compartments is essential for design and development of drug delivery ...
William K. Chan, Xiaoling Li
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Sulfur Metabolism in AIDS: Cystamine as an Anti-HIV Agent
AIDS Research and Human Retroviruses, 2009Numerous reports have documented disturbances of sulfur metabolism in AIDS patients. There is a generalized loss of sulfur from the body, measured as cysteine and glutathione. The enzyme, cystathionase, has been shown to be greatly decreased in the liver of AIDS patients.
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Evaluation of Candidate Anti-HIV Agents in vitro
1990Significant progress has been made in the development of anti-HIV therapies for patients with AIDS and other HIV-related illnesses [1-4]. Because of major advances in our understanding of the HIV-1 replicative cycle and identification of potential targets for anti-retroviral therapy, many newer agents are now undergoing preclinical and clinical drug ...
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Current Status of Anti-HIV Agents
Current Medicinal Chemistry -Anti-Infective Agents, 2005V. Tandon, R. Chhor
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