Results 201 to 210 of about 295,334 (238)
Repurposing Phytochemicals as Anti-HIV Agents [PDF]
Journal of Antivirals & Antiretrovirals, 2016 Phytochemicals play crucial role in inhibiting key enzymes involved in HIV-1 replication. Repurposing of phytochemical based anti-HIV drug discovery through cross screening approaches and modern techniques is essential to provide better leads. Anti-HIV leads translated through phytochemicals could overcome current challenges of HIV therapy. Considering
Smita Kulkarni +2 more
openaire +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Naturally derived anti‐HIV agents
Phytotherapy Research, 2005AbstractThe urgent need for new anti‐HIV/AIDS drugs is a global concern. In addition to obvious economical and commercial hurdles, HIV/AIDS patients are faced with multifarious difficulties associated with the currently approved anti‐HIV drugs. Adverse effects, the emergence of drug resistance and the narrow spectrum of activity have limited the ...
Asres, Kaleab +4 more
openaire +4 more sources
Pyrazole Containing Anti-HIV Agents: An Update
Medicinal Chemistry, 2022Background:Pyrazole scaffolds have gained importance in drug discovery and development for various pharmacological activities like antiviral, antifungal, anticancer, antidepressant, antiinflammatory, antibacterial, etc. Additionally, the pyrazole moiety has shown potent anti-HIV activity as a core heterocycle or substituted heterocycles derivatives ...
Sanjay, Kumar +3 more
openaire +2 more sources
Combinatorial Synthesis of anti‐HIV Agents
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
Ananantha Naik Nagappa +2 more
openaire +2 more sources
Natural Products as Anti- HIV Agents
Nigerian Quarterly Journal of Hospital Medicine, 2008Acquired immunodeficiency syndrome (AIDS) is a pandemic immunodegenerative disease caused by human immunodeficiency virus (HIV). The disease is ravaging, given the number of patients infected with the disease worldwide, the high mortality rate and attendant socio-economic casualties in affected countries, mostly in Africa.
H A Coker, S A Adesegun, G O Ajayi
openaire +2 more sources
Polyoxometalates and Fullerenes as Anti-HIV Agents [PDF]
, 1999 The lack of proofreading ability of HIV reverse transcriptase leads to errors and the development of drug-resistant HIV variants. This has prompted a concerted research effort to find new efficacious chemotherapies that are not cross-resistant with currently approved antiviral agents.
Craig L. Hill +3 more
openaire +1 more source
Rationally Designed Multitarget Anti-HIV Agents
Current Medicinal Chemistry, 2013Multitarget-directed ligands (MTDLs), an emerging and appealing drug discovery strategy, utilizing a single chemical entity to inhibit multitargets, was confirmed to be effective in reducing the likelihood of drug resistance, diminishing problems of dosing complexity, drug-drug interactions and toxicities, as well as improving patient compliance.
Peng Zhan, Xinyong Liu
openaire +3 more sources
New anti‐HIV agents and targets
Medicinal Research Reviews, 2002AbstractVirtually all the compounds that are currently used or are subject of advanced clinical trials for the treatment of HIV infections, belong to one of the following classes: (i) nucleoside reverse transcriptase inhibitors (NRTIs): i.e., zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir, emtricitabine and nucleotide reverse ...
openaire +4 more sources
Quinobene, a new potent anti-HIV agent
Biochemical and Biophysical Research Communications, 1992A simple synthesis of the sulfonated azo dye Quinobene (3) and its derivatives, as well as the results of their evaluation in anti-HIV screening have been described. Thus, reacting the diazonium salt of 4,4'-diaminostilbene-2,2'-disulfonic acid with 8-hydroxyquinoline-5-sulfonic acid yielded the readily isolable title compound.
Ewa Gruszecka-Kowalik +2 more
openaire +3 more sources
Combinatorial Synthesis of Anti-HIV Agents-A Review
Combinatorial Chemistry & High Throughput Screening, 2005Combinatorial chemistry has been well recognized as an important tool of drug discovery. An ongoing hand is to integrate the combinatorial approach with fundamentals of medicinal chemistry and rational drug design. The last five years has seen an explosion in the exploration and adoption of combinatorial techniques.
Dharmarajan Sriram +2 more
openaire +2 more sources