Results 211 to 220 of about 295,334 (238)

Ribozymes as Potential Anti-HIV-1 Therapeutic Agents [PDF]

Science, 1990
Certain RNA molecules, called ribozymes, possess enzymatic, self-cleaving activity. The cleavage reaction is catalytic and no energy source is required. Ribozymes of the "hammerhead" motif were identified in plant RNA pathogens. These ribozymes possess unique secondary (and possibly tertiary) structures critical for their cleavage ability.
Edouard M. Cantin, Paula A. Ladne, John J. Rossi, John A. Zaia, Delilah A. Stephens, Nava Sarver, Pairoj Chang, Pairoj Chang   +7 more
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DNA aptamers as potential anti-HIV agents

Trends in Biochemical Sciences, 2005
Guanine (G)-rich DNA sequences can adopt stable G-quadruplex structures by G-tetrad hydrogen-bonding and hydrophobic stacking. Recently, it has been shown that a DNA sequence forms an aptamer (termed 93del) and adopts a novel dimeric quadruplex folding topology in K+ solution. This aptamer exhibits anti-HIV1 integrase activity in the nanomolar range in
Ko-Hsin Chin, Shan-Ho Chou, Andrew H.-J. Wang   +2 more
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New Azt Conjugates as Potent Anti-HIV Agents

Nucleosides, Nucleotides and Nucleic Acids, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Henry J. Lee, Zhengqing You
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Total Synthesis of Anti-HIV Agent Chloropeptin I

Journal of the American Chemical Society, 2003
A convergent diastereo- and enantioselective total synthesis of anti-HIV agent chloropeptin I is reported. Important features of the total synthesis include: (1) the use of Ti-catalyzed cyanide addition to imines to prepare a requisite amino acid moiety, (2) the discovery of the positive effect of MeOH in the Cu-mediated biaryl ether formation to ...
Tao Liu, Marc L. Snapper, Kevin W. Kuntz, Amir H. Hoveyda, Hongbo Deng, Jae-Kyung Jung   +5 more
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6-Aminoquinolones as New Potential Anti-HIV Agents

Journal of Medicinal Chemistry, 2000
A series of 6-aminoquinolone compounds were evaluated for their in vitro activity against human immunodeficiency virus type 1 (HIV-1). Compound 12a, bearing a methyl substituent at the N-1 position and a 4-(2-pyridyl)-1-piperazine moiety at the C-7 position, was the most active in inhibiting HIV-1 replication on de novo infected C8166 human ...
V. CECCHETTI, PAROLIN, MARIA CRISTINA, MORO, STEFANO, PECERE T., E. FILIPPONI, CALISTRI, ARIANNA, O. TABARRINI, GATTO, BARBARA, PALUMBO, MANLIO, A. FRAVOLINI, PALU', GIORGIO   +10 more
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Natural Products as Anti-HIV Agents

1992
The publication, in 1981, of a report announcing the occurrence of a cluster of diagnoses of a rare form of pneumonia due to the microorganism Pneumocystis carinii in a group of male homosexuals in San Francisco constitutes the first notice of the advent of a new disease. It was quickly recognized, subsequent to that report, that the occurrence of this
Daniel Lednicer, Ven L. Narayanan
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ChemInform Abstract: Synthesis and Anti‐HIV Activity of Arylpiperazinyl Fluoroquinolones: A New Class of Anti‐HIV Agents.

ChemInform, 1999
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tetsushi Katsube, Satoshi Kimura, Hiroto Kashiwase, Kenji Momota, Takashi Nishigaki, Toshinori Ohmine, Tomoaki Komai, Masahiko Hagihara, Tomio Kimura, Kaoru Shimada   +9 more
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Tetrahydrothiophene nucleosides as potential anti-HIV agents

Tetrahedron Letters, 1991
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Martin Francis Jones, Colin A. Robertson, Stewart A. Noble, Richard Storer   +3 more
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Iminosugar glycosylation inhibitors as anti-HIV agents

Perspectives in Drug Discovery and Design, 1993
A novel class of compounds which are potent inhibitors of the posttranslational glycan trimming enzyme α-glucosidase I have been found to display anti-HIV activity. These compounds are iminosugar analogs ofd-glucose, with the oxygen in the ring replaced by a nitrogen, and were originally isolated from plants and microorganisms, although a considerable ...
Gary S. Jacob, Martin L. Bryant
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Evaluation of tea polyphenols as anti-HIV agents

Bioorganic & Medicinal Chemistry Letters, 1996
Thirty-eight tea polyphenols were evaluated for their inhibitory effect against HIV replication in H9 lymphocyte cells. 8-C-Ascorbyl (−)-epigallocatechin (13) and theasinensin-D (32) demonstrated relatively potent anti-HIV activity with EC50 values of 4 and 8 μg/mL and therapeutic indexes of 9.5 and 5, respectively.
Toshihiro Nohara, L. Mark Cosentino, Gen-ichiro Nonaka, Itsuo Nishioka, Fumlo Hashimoto, Fumlo Hashimoto, Yoshiki Kashiwada, Kuo Hsiung Lee   +7 more
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