Results 31 to 40 of about 686,239 (385)

Waking Up the Sleepers: HIV Latency and Reactivation

Journal of the Formosan Medical Association, 2008
In a patient infected with HIV-1, the presence of latently infected cells from which the virus can be reactivated and rekindle HIV infection in the patient necessitates lifelong administration of antiretroviral treatment.
Hoi Ping Mok, Andrew Lever
doaj   +1 more source

Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents. [PDF]

, 2018
HIV latency in resting CD4+ T cell represents a key barrier preventing cure of the infection with antiretroviral drugs alone. Latency reversing agents (LRAs) can activate HIV expression in latently infected cells, potentially leading to their elimination
DeChristopher, Brian A, Hardman, Clayton T, Ho, Stephen, Loy, Brian A, Marsden, Matthew D, Navab, Sara M, Ramirez, Christina M, Schrier, Adam J, Shimizu, Akira J, Wender, Paul A, Wu, Xiaomeng, Zack, Jerome A   +11 more
core   +1 more source

Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection. [PDF]

, 2007
BackgroundWe reported previously on the emergence and clinical implications of simian immunodeficiency virus (SIVmac251) mutants with a K65R mutation in reverse transcriptase (RT), and the role of CD8+ cell-mediated immune responses in suppressing ...
Bischofberger, Norbert, Blackwood, Emily J, Heneine, Walid, Johnson, Jeffrey A, Lipscomb, Jonathan, Marthas, Marta L, Matthews, Timothy B, North, Thomas W, Pedersen, Niels C, Singh, Raman P, Van Rompay, Koen KA   +10 more
core   +3 more sources

Investigation of Seroprevalence of Hepatitis B, Hepatitis C and HIV in Hemodialysis Patients

Journal of Contemporary Medicine, 2021
Aim: Impairments in the immune system of patients undergoing HD cause patients to be more sensitive to infection agents. The purpose of this study; to determine the seroprevalance of HBV, HCV and HIV in patients undergoing hemodialysis treatment ...
Duygu Fındık, Gülperi Çelik, Rugıyya Samadzade, Salih Maçin, Ahmed Nsangou   +4 more
doaj   +2 more sources

Otolaryngologic manifestations in HIV disease: clinical aspects and treatment Manifestações otorrinolaringológicas na infecção pelo HIV: aspectos clínicos e terapêuticos

Brazilian Journal of Otorhinolaryngology, 2011
HIV is a pandemic infection with cases notified in almost all countries. The reported prevalence of symptoms in the head and neck is about 80%; otolaryngologists may be the first physician to see such patients.
Fernanda Alves Sanjar, Barbara Elvina Ulisses Parente Queiroz, Ivan Dieb Miziara   +2 more
doaj   +1 more source

Development of Mucoadhesive Gel Microbicide to Target Mucosal HIV Reservoirs [PDF]

, 2014
The wide use of microbicide is mainly depends on its effectiveness, less frequent application, ready availability and most importantly cost. The aim of this work was to develop affordable microbicide mucoadhesive gel formulation of synthetic anti HIV ...
Shegokar, Ranjita, Singh, Kamalinder K
core   +1 more source

RNA interference approaches for treatment of HIV-1 infection. [PDF]

, 2015
HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L, Burnett, John C, Rossi, John J   +2 more
core   +1 more source

New findings on the d(TGGGAG) sequence: Surprising anti-HIV-1 activity [PDF]

, 2018
The biological relevance of tetramolecular G-quadruplexes especially as anti-HIV agents has been extensively reported in the literature over the last years. In the light of our recent results regarding the slow G-quadruplex folding kinetics of ODNs based
Di Fabio, Giovanni, Liekens, Sandra, Noppen, Sam, Pannecouque, Christophe, Romanucci, Valeria, Zarrelli, Armando   +5 more
core   +1 more source

Design, synthesis, molecular dynamics studies and biological evaluations of 4-hydroxy-5-pyrrolinone-3-carbohydrazides as HIV-1 integrase inhibitors

European Journal of Medicinal Chemistry Reports
Acquired immune deficiency syndrome (AIDS) diseases despite the efficacy of anti-HIV therapy, remain one of the human's most serious problems. Hence, the introduction of novel anti-HIV agents as first-line therapy is still required. HIV integrase lacking
Nafiseh Karimi, Amirreza Dowlati Beirami, Rouhollah Vahabpour Roudsari, Zahra Hajimahdi, Afshin Zarghi   +4 more
doaj   +1 more source

Dendrimers as Potential Therapeutic Tools in HIV Inhibition

Molecules, 2013
The present treatments for HIV transfection include chemical agents and gene therapies. Although many chemical drugs, peptides and genes have been developed for HIV inhibition, a variety of non-ignorable drawbacks limited the efficiency of these ...
Xiangbo Li, Yi Chen, Xiaole Qi, Zhenghong Wu, Jianqing Peng   +4 more
doaj   +1 more source