Results 91 to 100 of about 2,269,213 (187)

Advances in study on diagnosis and treatment of immune-mediated necrotizing myopathy [PDF]

Zhenduanxue lilun yu shijian
Immune-mediated necrotizing myopathy (IMNM) is a significant, subtype of idiopathic inflammatory myopathy（IIM）, characterized by symmetrical proximal limb muscle weakness and markedly elevated serum creatine kinase levels.
LIU Hongjiang, XIE Qibing
doaj   +1 more source

Atypical skin conditions of the neck and back as a dermal manifestation of anti-HMGCR antibody-positive myopathy

BMC Immunology
Abstract Background Immune-mediated necrotizing myopathy (IMNM) is an idiopathic inflammatory myopathy (IIM). Though patients with IMNM were not considered to show skin rash, several reports have showed atypical skin conditions in patients with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibody ...
Takashi Kurashige, Rie Nakamura, Tomomi Murao, Naoko Mine, Mayu Sato, Riho Katsumata, Yuhei Kanaya, Yoriko Dodo, Tomohito Sugiura, Tomohiko Ohshita   +9 more
openaire   +3 more sources

Statin-induced anti-HMGCR antibody-related immune-mediated necrotising myositis achieving complete remission with rituximab

BMJ Case Reports, 2019
Statin-induced immune-mediated necrotising myopathy (IMNM) is a rare but increasingly recognised myositis. Many cases have positive antibodies to 3-hydroxy-3-methylglutaryl coenzyme A reductase (anti-HMGCR). The current treatment is ceasing the statin, but often immunosuppressive therapy is required as the antibodies persist, causing muscle necrosis ...
Wenwen Zhang, Henry Miles Prince, Katrina Reardon   +2 more
openaire   +3 more sources

Immune-Mediated Necrotizing Myopathy (IMNM): A Story of Antibodies

Antibodies
Immune-mediated necrotizing myopathy (IMNM) is a rare and severe disease that corresponds to a specific entity of idiopathic inflammatory myopathy. Patients with IMNM suffer from proximal muscle weakness, and present high levels of creatine kinase and ...
Sarah Julien, Inès Challier, Marine Malleter, Fabienne Jouen, Laurent Drouot, Olivier Boyer   +5 more
doaj   +1 more source

Autoimmune necrotising myopathy and HMGCR antibodies

, 2018
Statins lower serum cholesterol concentrations by inhibiting the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). Muscle side effects are relatively common and include asymptomatic elevation of serum creatine kinase (CK), myalgia, proximal
Monika Hofer, Dimitri Amiras, Stuart Viegas, Kushan Karunaratne, Matthew C Pickering   +4 more
core   +1 more source

Association of clinical features and myositis-specific antibodies in idiopathic inflammatory myopathy: a retrospective study from southern China

Frontiers in Immunology
This study aimed to investigate the profiles of myositis-specific autoantibodies (MSA) and their correlation with distinct clinical features in patients with idiopathic inflammatory myopathy (IIM) in southern China.
Can Li, Yushi Zheng, Yu Zhang, Yu Zhang, Yujin Ye, Hui Zhang, Niansheng Yang, Shuang Wang   +7 more
doaj   +1 more source

Upregulated miR-146b-3p predicted rheumatoid arthritis development and regulated TNF-α-induced excessive proliferation, motility, and inflammation in MH7A cells

BMC Immunology
Background Rheumatoid arthritis (RA) is a chronic immune system disease with a high disability rate threatening the living quality of patients. Identifying potential biomarkers for RA is of necessity to improve the prevention and management of RA ...
Linxiao Ma, Huijie Liu, Ping Shao, Qian Lv   +3 more
doaj   +1 more source

Myositis-associated antibodies predict the severity of lung involvement in adult patients with inflammatory myositis − a cohort study of 70 adult patients with myositis in a single center

Frontiers in Medicine
IntroductionIdiopathic inflammatory myopathies (IIMs) encompass a diverse group of diseases characterized by considerable variability in clinical manifestations, antibody profiles, and responsiveness to immunosuppressive therapies.
Josefin Marklund, Balsam Hanna, Tao Jin, Tao Jin, Rille Pullerits, Rille Pullerits, Rille Pullerits   +6 more
doaj   +1 more source

Guillain-Barré Syndrome-related campylobacter jejuni in Bangladesh: ganglioside mimicry and cross-reactive antibodies [PDF]

, 2012
BACKGROUND: <br/> Campylobacter jejuni is the predominant antecedent infection in Guillain-Barré syndrome (GBS). Molecular mimicry and cross-reactive immune responses to C.
Klaij, K, Talukder, K.A. (Kaisar), Tio-Gillen, Anne P., Endtz Hubert P., Gilbert Michel, Klaij, K., Jianjun Li (139837), Anne P. Tio-Gillen (139842), Talukder, K.A., Gilbert, Michel, Klaij, Kevin, Kaisar A Talukder, Gillen, Anne, Islam, Zhahirul, Tio-Gillen Anne P., Quazi D Mohammad, Talukder, KA, Talukder, Kaisar A., Gilbert, M., van Rijs, W., Jacobs, Bart C., Alex van Belkum (38419), Hugh J Willison, Islam, Z. (Zhahirul), van Rijs, Wouter, Kevin Klaij, Jacobs Bart C., Willison, H.J. (Hugh), Quazi D. Mohammad (139834), Li, J. (Jianjun), Klaij Kevin, Talukder Kaisar A., Willison, HJ, Mohammad, Quazi D., Gilbert, M. (Michel), Klaij, K. (Kevin), Jacobs, B.C. (Bart), Bart C. Jacobs (139863), Endtz, Hubert, Jianjun Li, Bart C Jacobs, Li, J., Willison, Hugh J., Willison Hugh J., Kevin Klaij (139835), Rijs, Wouter, Zhahirul Islam, Tio-Gillen, A.P., Willison, H.J., Michel Gilbert (60775), Endtz, H.P., van Belkum Alex, Jacobs, B.C., Endtz, Hubert P., Mohammad, QD, van Belkum, Alex, Hugh J. Willison (139850), Mohammad Quazi D., van Rijs Wouter, Hubert P. Endtz (139857), Li, JJ, Michel Gilbert, Kaisar A. Talukder (139846), Mohammad, Q.D., Wouter van Rijs, Mohammad, Q.D. (Quazi), Zhahirul Islam (139833), Belkum, Alex, Hubert P Endtz, Gilbert, M, Belkum, A.F. (Alex) van, Islam Zhahirul, Islam, Z, Islam, Z., Tio-Gillen, A.P. (Anne), Endtz, H.P. (Hubert), Anne P Tio-Gillen, Wouter van Rijs (139839), Rijs, W. (Wouter) van, van Belkum, A., Li, Jianjun, Li Jianjun, Alex van Belkum   +82 more
core   +3 more sources

Anti-HMGCR myopathy may resemble limb-girdle muscular dystrophy

, 2018
International audienceObjective To determine the prevalence and clinical features of anti-HMGCR myopathy among patients with presumed limb-girdle muscular dystrophy (LGMD) in whom genetic testing has failed to elucidate causative mutations.
Fequiere, Pierre, Béhin, Anthony, Stojkovic, Tanya, Bönnemann, Carsten, Bönnemann, Carsten G, Toro, Camilo, Harper, Amy, Drachman, Daniel, Shebert, Robert T, Lafôret, Pascal, Pak, Katherine S, Foley, A Reghan, Mohassel, Payam, Wahl, Colleen, Eymard, Bruno, Mammen, Andrew L, Mammen, Andrew, Benveniste, Olivier, Pak, Katherine, Donkervoort, Sandra, Foley, A. Reghan, Meriggioli, Matthew, Landon-Cardinal, Océane, Allenbach, Yves, Shebert, Robert   +24 more
core   +1 more source