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Statin-naïve anti-HMGCR antibody-mediated necrotizing myopathy in China
Journal of Clinical Neuroscience, 2018This study aimed to clarify the phenotypes and therapeutic responses of statin-naïve anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibody-mediated necrotizing myopathy. Anti-HMGCR antibodies were tested with ELISA methodology in the sera sample of 98 patients meeting the idiopathic inflammatory myopathy criteria and with negative anti ...
Yuqiong Jiao +11 more
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Revue Tunisienne de BIOLOGIE CLINIQUE, Vol. 31 No 2 (2024): Edition spéciale : «Auto-anticorps : le mystère révélé»
Soli, Arij, Bouzakoura, Firas
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Soli, Arij, Bouzakoura, Firas
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Scandinavian Journal of Rheumatology, 2016
3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) inhibitors, also known as statins, are widely used for cardiovascular and atherosclerosis disease prevention and therapy.
GIUDIZI, MARIA GRAZIA +8 more
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3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) inhibitors, also known as statins, are widely used for cardiovascular and atherosclerosis disease prevention and therapy.
GIUDIZI, MARIA GRAZIA +8 more
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Anti-HMGCR antibodies can be accurately detected by indirect immunofluorescence on HEp-2000substrate
PathologyDetection of myositis-specific autoantibodies (MSAs) is important in the diagnosis and subtyping of idiopathic inflammatory myopathies (IIMs). Widespread use of the line immunoassay (LIA) for MSA detection has significant limitations due to a high false positive rate.
Hamish Anderson +3 more
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Anti-HMGCR Antibody Associated Necrotizing Autoimmune Myopathy-A Case-Based Clinical Review
Journal of Clinical and Medical Research, 2019A 54 years gentleman presented with proximal and distal myopathies with history of statin exposure with persistent symptoms posts statin cessation. CPK ranged from 18000 to 25000 IU/L. Lower limbs MRI showed extensive bilateral muscle oedema consistent with myositis. EMG was consistent with an inflammatory myopathic disease.
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Annales de dermatologie et de venereologie, 2020
Statin-induced necrotizing autoimmune myopathy (NAM) has been recently characterized. Herein we report an accurate description of the clinical and histological characteristics of cutaneous rash associated with NAM.A 61-year-old woman presented a skin rash involving the face, the chest and the back of the hands with heliotropic distribution coupled with
M, Merlant +6 more
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Statin-induced necrotizing autoimmune myopathy (NAM) has been recently characterized. Herein we report an accurate description of the clinical and histological characteristics of cutaneous rash associated with NAM.A 61-year-old woman presented a skin rash involving the face, the chest and the back of the hands with heliotropic distribution coupled with
M, Merlant +6 more
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A Case of Smoldering Anti-HMGCR antibody Myopathy (P9-8.015)
Neurology, 2023openaire +1 more source
Rheumatology
Abstract Background/Aims Anti-HMGCR antibodies are associated with a rare form of immune mediated necrotizing myopathy. Statin exposure is common, but statin-naïve presentations can occur. Given its rarity, optimal treatment regimes, alternative cholesterol lowering therapy, and implications of ...
Kristina E Clark +8 more
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Abstract Background/Aims Anti-HMGCR antibodies are associated with a rare form of immune mediated necrotizing myopathy. Statin exposure is common, but statin-naïve presentations can occur. Given its rarity, optimal treatment regimes, alternative cholesterol lowering therapy, and implications of ...
Kristina E Clark +8 more
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From Serendipity to Science: How Anti-HMGCR Antibodies Changed Our Understanding of Myositis
The Journal of RheumatologyAlthough statin-induced muscle toxicity was recognized, a subset of patients presented with severe, persistent necrotizing myopathy despite statin withdrawal. Recognized initially through the serendipitous aggregation of cases in the longitudinal myositis cohort at the Johns Hopkins Myositis Center, the anti–3-hydroxy-3-methylglutaryl-coenzyme A ...
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Necrotizing myopathy with elevated anti-HMGCR antibodies following exposure to the supplement Bacopa
Muscle and Nerve, 2023Maxwell Greene +2 more
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