Results 31 to 40 of about 112,322 (317)

Recent progress in the discovery of macrocyclic compounds as potential anti-infective therapeutics [PDF]

, 2009
Novel therapeutic strategies are urgently needed for the treatment of serious diseases caused by viral, bacterial and parasitic infections, because currently used drugs are facing the problem of rapidly emerging resistance.
Bernardini, F, Bisang, C, DeMarco, S J, Gombert, F O, Moehle, K, Obrecht, D, Robinson, J A   +6 more
core   +1 more source

Hybrid Compounds as Anti-infective Agents

Current Topics in Medicinal Chemistry, 2017
Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or pharmacophores covalently linked in a single molecule. In the field of anti-infective agents, they have been proposed as a possible solution to drug resistance issues, presumably having a broader spectrum of activity and less probability of eliciting high level resistance ...
Sbaraglini, Maria Laura, Talevi, Alan
openaire   +4 more sources

Anti-infective Agents [PDF]

, 2015
Infections may be hazardous to the health of the mother, the course of pregnancy, and the unborn child. They can lead to premature labor or premature rupture of membranes and thereby increase the risk for spontaneous abortion and prematurity. Furthermore, certain germs can pass to the unborn child and harm it directly.
openaire   +1 more source

Successful ceftolozane/tazobactam treatment of chronic pulmonary infection with pan‐resistant Pseudomonas aeruginosa [PDF]

, 2015
The treatment of chronic Pseudomonas aeruginosa infections is challenging, with resistance and antibiogram diversity accumulating during successive therapies.
Andrews, Ashish, Boucher, Chandorkar, Juan, Lepak, Livermore, Shlaes, Turton, VanScoy   +9 more
core   +1 more source

Evaluation of the use of systemic antimicrobial agents by professionals for the treatment of periodontal diseases

Brazilian Journal of Oral Sciences, 2015
Aim: To investigate the indication of systemic antimicrobial agents used by dental professionals for treatment of patients affected by periodontal diseases.
Aline Vicentini Monteiro, Fernanda Vieira Ribeiro, Renato Corrêa Viana Casarin, Fabiano Ribeiro Cirano, Suzana Peres Pimentel, Márcio Zaffalon Casati   +5 more
doaj   +1 more source

Thiourethane-functionalized fillers: biological properties and degradation resistance [PDF]

Brazilian Oral Research
This study determined the effect of thiourethane-functionalized fillers (TU) on the antimicrobial properties, cytotoxicity, degree of conversion (DC), water sorption (Wsp) and solubility (Wsl) of experimental composites. TU-modified fillers were added at
Larissa Maria CAVALCANTE, Amanda Barreto RAMOS, Daniela Costa SILVA, Gutemberg Gomes ALVES, Karinne Bueno ANTUNES, Carmem Silvia PFEIFER, Luis Felipe Jochims SCHNEIDER   +6 more
doaj   +2 more sources

Strategies to prevent the occurrence of resistance against antibiotics by using advanced materials [PDF]

, 2018
This is a post-peer-review, pre-copyedit version of an article published in Applied microbiology and biotechnology The final authenticated version is available online at: http://dx.doi.org/10.1007/s00253-018-8776-0Drug resistance occurrence is a global ...
Bassegoda Puigdomenech, Arnau, Ivanova, Kristina Dimitrova, Ramon Portés, Eva, Tzanov, Tzanko   +3 more
core   +2 more sources

Influence of addition of [2-(methacryloyloxy)ethyl]trimethylammonium chloride to an experimental adhesive

Brazilian Oral Research, 2017
The aim of this study was to develop an experimental adhesive with addition of [2-(methacryloyloxy)ethyl]trimethylammonium chloride (METAC) and to evaluate its mechanical and biological properties and its in vitro antibacterial activity.
Fabrício Mezzomo COLLARES, Vicente Castelo Branco LEITUNE, Patrícia FRANKEN, Clarissa Fatturi PAROLLO, Fabrício Aulo OGLIARI, Susana Maria Werner SAMUEL   +5 more
doaj   +1 more source

Teixobactin: a novel anti-infective agent [PDF]

Expert Review of Anti-infective Therapy, 2018
In 2015, a screen of bacterial strains produced a novel antibiotic with broad antimicrobial activity known as teixobactin [1].
openaire   +2 more sources

Network model of immune responses reveals key effectors to single and co-infection dynamics by a respiratory bacterium and a gastrointestinal helminth [PDF]

, 2012
Co-infections alter the host immune response but how the systemic and local processes at the site of infection interact is still unclear. The majority of studies on co-infections concentrate on one of the infecting species, an immune function or group of
A Graham, A Saadatpour, AJ Bancroft, AK Pathak, AK Pathak, AK Pathak, AL Graham, AP Boyd, Ashutosh K. Pathak, C Campbell, C Espinosa-Soto, C Lacroux, CA Behm, CA Blish, CA Figueiredo, CC Chen, CD Bourke, DL Abraham, DN Wolfe, EJ Pishko, ER Walsh, F Audebert, FD Finkelman, FE Cox, GB Harrison, GR Stewart, GS Kirimanjeswara, IM Cattadori, IM Cattadori, Isabella M. Cattadori, J Holmgren, J Thakar, J Thakar, J Thakar, JA Jackson, JD Turner, JE Allen, JG Fox, JS Fahel, JT Pesce, Juilee Thakar, L Glass, L Murphy, L Sanchez, Lisa Murphy, LJ Wang, M Chaves, MR Pilione, MT Brady, NG Henderson, NW Brattig, P Gueirard, P Matzinger, R Zhang, RK Grencis, RM Anthony, Rob J. De Boer, Réka Albert, S Bornholdt, S Cornell, S Li, S Mattoo, SM Assmann, SM Geiger, T Beyer, T Resende Co, TM Stock, V Haukisalmi, WI Khan, X Xu   +69 more
core   +4 more sources