Results 1 to 10 of about 1,576,470 (150)
Frontiers in Pharmacology, 2022 Hepatitis is a complex multifactorial pathological disorder, which can eventually lead to liver failure and even potentially be life threatening. Paeoniflorin-6′-O-benzene sulfonate (CP-25) has proven to have critical anti-inflammatory effects in ...
Nan Li +11 more
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Stem Cell Research & Therapy, 2021 Background Tumor necrosis factor (TNF)-α inhibitors represented by Etanercept (a fusion protein containing soluble TNF receptor II (sTNFRII) and the Fc segment of human IgG1) play a pivotal role in Rheumatoid arthritis (RA) treatment.
Yingjie Zhao +9 more
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Cell Communication and Signaling, 2023 In essence, the β2 adrenergic receptor (β2AR) plays an antiproliferative role by increasing the intracellular cyclic 3’,5’-adenosine monophosphate (cAMP) concentration through Gαs coupling, but interestingly, β2AR antagonists are able to effectively ...
Mingli Ge +11 more
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Pharmaceuticals, 2023 G protein-coupled receptor kinase 2 (GRK2) is one of the cytosolic enzymes, and GRK2 translocation induces prostaglandin E2 receptor 4 (EP4) over-desensitization and reduces the level of cyclic adenosine monophosphate (cAMP) to regulate macrophage ...
Jiawei Zhang +11 more
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Gα12 and Gα13: Versatility in Physiology and Pathology
Frontiers in Cell and Developmental Biology, 2022 G protein-coupled receptors (GPCRs), as the largest family of receptors in the human body, are involved in the pathological mechanisms of many diseases.
Paipai Guo +8 more
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Journal of Pharmacological Sciences, 2021 Paeoniflorin-6′-O-benzene sulfonate (CP-25) is a derivative of Paeoniflorin. We investigate beneficial effect of CP-25 on methotrexate (MTX) induced nephrotoxicity in rats.
Xiao Wei +8 more
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Pharmaceutical Biology, 2020 Context Ginsenoside compound K (CK) has anti-inflammatory, immunoregulatory, and myelosuppressive protective effects. Methotrexate (MTX) is widely used in combination therapy for rheumatoid arthritis (RA). Objective To evaluate the effects of combination
Jingyu Chen +4 more
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Immune-Cell-Based Therapy for COVID-19: Current Status
Viruses, 2023 Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. The interplay between innate and adaptive immune responses plays a crucial role in managing COVID-19.
Yiyuan Wang +7 more
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MicroRNA-10b promotes arthritis development by disrupting CD4+ T cell subtypes
Molecular Therapy: Nucleic Acids, 2022 Rheumatoid arthritis (RA) is an inflammation-involved disorder and features the disruption of CD4+ T lymphocytes. Herein, we describe that microRNA-10b-5p (miR-10b) promotes RA progression by disrupting the balance between subsets of CD4+ T cells.
Jiajie Tu +9 more
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New insights into the Lck-NF-κB signaling pathway
Frontiers in Cell and Developmental Biology, 2023 Lck is essential for the development, activity, and proliferation of T cells, which may contribute to pathological progression and development of human diseases, such as autoimmune disorders and cancers when functioning aberrantly.
Jing Zhang +4 more
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