Results 11 to 20 of about 1,414,086 (297)
Are statins anti-inflammatory? [PDF]
Trials, 2000 Large scale clinical trials demonstrate significant reductions in cardiovascular event rates with statin therapy. The observed benefit of statin therapy, however, may be larger in these trials than that expected on the basis of lipid lowering alone. Emerging evidence from both clinical trials and basic science studies suggest that statins have anti ...
Blake, Gavin J., Ridker, Paul M.
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The anti-inflammatory mechanisms of Hsp70 [PDF]
Frontiers in Immunology, 2012 Immune responses to heat shock proteins (Hsp) develop in virtually all inflammatory diseases; however, the significance of such responses is only now becoming clear. In experimental disease models, Hsp administration can prevent or arrest inflammatory damage, and in initial clinical trials in patients with chronic inflammatory diseases, Hsp peptides ...
Borges, T.J. +6 more
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Anti‐Inflammatory Natural Products [PDF]
Mediators of Inflammation, 2015 Inflammation is the first biological response of the immune system against infection or irritation. However, accumulating epidemiological and clinical study indicates that zealous acute inflammation or chronic inflammatory reaction is a significant risk factor to develop various human diseases.
Yifu Yang +3 more
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Chenopodin as an anti-inflammatory compound
Natural Product Research, 2021 Chenopodin is an 11S-type globulin purified from Chenopodium quinoa seeds, which can bind carbohydrates and hemagglutinating human erythrocytes. The present study aimed to evaluate the N-terminal structure of the heterodimeric Chenopodin and its effects in models of inflammation.
Dávia Guimarães Pompeu (11461193) +10 more
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Bidirectional Role of β2-Adrenergic Receptor in Autoimmune Diseases
Frontiers in Pharmacology, 2018 Disorder of the sympathetic nervous system (SNS) is closely related to the pathogenesis of various autoimmune diseases (ADs). Catecholamine triggered beta2-adrenergic receptor (β2-AR) signaling is important in creating a bidirectional response in the ...
Li Wu +9 more
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Infectious Agents and Cancer, 2023 Metastasis has emerged as a major impediment to achieve successful therapeutic outcomes in hepatocellular carcinoma (HCC). Nonetheless, the intricate molecular mechanisms governing the progression of HCC remain elusive.
Xiu Chen +8 more
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NLRP3 inflammasome activation mechanism and its role in autoimmune liver disease
Acta Biochimica et Biophysica Sinica, 2022 The NLRP3 inflammasome is a multiprotein binding compound comprising NLRP3, connector protein ASC, and effector protein pro-caspase-1. When the NLRP3 inflammasome senses a danger signal from the host or pathogen, activated caspase-1 cleaves the ...
Guan Yanling +8 more
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Frontiers in Molecular Neuroscience, 2019 The essential roles of microglia in maintaining homeostasis in the healthy brain and contributing to neuropathology are well documented. Emerging evidence suggests that epigenetic modulation regulates microglial behavior in both physiological and ...
Yawei Guo +7 more
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Anti‐inflammatory actions of acupuncture [PDF]
Mediators of Inflammation, 2003 Acupuncture has a beneficial effect when treating many diseases and painful conditions, and therefore is thought to be useful as a complementary therapy or to replace generally accepted pharmacological intervention. The attributive effect of acupuncture has been investigated in inflammatory diseases, including asthma, rhinitis, inflammatory bowel ...
Jan Klein +3 more
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Frontiers in Immunology, 2018 Fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS) are the two main cellular components of the synovium. It has been widely reported that FLS and MLS play essential roles in the joint pathology of rheumatoid arthritis (RA ...
Jiajie Tu +7 more
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