Results 11 to 20 of about 2,175,618 (339)

Are statins anti-inflammatory? [PDF]

Trials, 2000
Large scale clinical trials demonstrate significant reductions in cardiovascular event rates with statin therapy. The observed benefit of statin therapy, however, may be larger in these trials than that expected on the basis of lipid lowering alone. Emerging evidence from both clinical trials and basic science studies suggest that statins have anti ...
Blake, Gavin J., Ridker, Paul
openaire   +5 more sources

Design of an anti-inflammatory diet (ITIS diet) for patients with rheumatoid arthritis. [PDF]

, 2020
Background:Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Agustín-Perez, Meritxall, Bustamante, Marta F, Cedola, Francesca, Coras, Roxana, Golshan, Shahrokh, Guma, Monica, Narasimhan, Rekha   +6 more
core   +2 more sources

The anti-inflammatory mechanisms of Hsp70 [PDF]

Frontiers in Immunology, 2012
Immune responses to heat shock proteins (Hsp) develop in virtually all inflammatory diseases; however, the significance of such responses is only now becoming clear. In experimental disease models, Hsp administration can prevent or arrest inflammatory damage, and in initial clinical trials in patients with chronic inflammatory diseases, Hsp peptides ...
Borges, T.J., Wieten, L., van Herwijnen, M.J.C., Broere, F., van der Zee, R., Bonorino, C., van Eden, W.   +6 more
openaire   +6 more sources

Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future

Mediators of Inflammation, 2020
The ontogeny of macrophages in most organs has already been established. Owing to the limited number and inaccessibility of synovial macrophages (SMs), the origin of SMs has not been fully elucidated.
Jiajie Tu, Xinming Wang, Xun Gong, Wenming Hong, Dafei Han, Yilong Fang, Yawei Guo, Wei Wei   +7 more
doaj   +1 more source

The glucocorticoid receptor in inflammatory processes : transrepression is not enough [PDF]

, 2015
Glucocorticoids (GCs) are the most commonly used anti-inflammatory agents to treat inflammatory and immune diseases. However, steroid therapies are accompanied by severe side-effects during long-term treatment. The dogma that transrepression of genes, by
Dejager, Lien, Hübner, Sabine, Libert, Claude, Tuckermann, Jan P   +3 more
core   +2 more sources

Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases

Frontiers in Pharmacology, 2018
The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the progression of the immune response including autoimmune diseases. Antigen presentation on immune cell surface, formation of an immunological synapse (IS),
Yu Tai, Qingtong Wang, Heinrich Korner, Heinrich Korner, Lingling Zhang, Wei Wei   +5 more
doaj   +1 more source

Simvastatin inhibits TLR8 signaling in primary human monocytes and spontaneous TNF production from rheumatoid synovial membrane cultures [PDF]

, 2015
Simvastatin has been shown to have anti-inflammatory effects that are independent of its serum cholesterol lowering action, but the mechanisms by which these anti-inflammatory effects are mediated have not been elucidated.
A Gierut, A Hilgendorff, AA Ajibade, BI Gavrila, BP Leung, C Arnaud, C Guiducci, C Guijarro, E Munro, EH Choy, FL Zhang, FM Brennan, FM Brennan, FX Zhang, G Falgarone, H Kanda, H Kanda, H Lin, H Methe, H Okamoto, H Radner, H Wesche, H Xu, I Zelvyte, J Qin, Jason Ferdjani, K Chaabo, KA Fitzgerald, KA Fitzgerald, KH Costenbader, KI Paraskevas, L Liu, LA O’Neill, Lisa Mullen, LM Mullen, M Khoury, M Ortego, M Yamamoto, M Yoshida, MA Gonzalez-Gay, QQ Huang, S Alzabin, S Doornum Van, Sandra Sacre, SL Chinault, SM Sacre, T Mosmann, TT Tang, U Schonbeck   +48 more
core   +1 more source

Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats

Acta Pharmaceutica Sinica B, 2021
Rheumatoid arthritis (RA) is an autoimmune disease and is mainly characterized by abnormal proliferation of fibroblast-like synoviocytes (FLS). The up-regulated cellular membrane expression of G protein coupled receptor kinase 2 (GRK2) of FLS plays a ...
Chenchen Han, Yifan Li, Yuwen Zhang, Yang Wang, Dongqian Cui, Tingting Luo, Yu Zhang, Qian Liu, Hao Li, Chun Wang, Dexiang Xu, Yang Ma, Wei Wei   +12 more
doaj   +1 more source

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. [PDF]

, 2008
Following our previous research on anti-inflammatory drugs (NSAIDs), we report here the synthesis of chiral 1,5-diarylpyrroles derivatives that were characterized for their in vitro inhibitory effects toward cyclooxygenase (COX) isozymes.
ANZELLOTTI P., ANZINI M., BIAVA M., BOTTA M., CIRILLI R., FERRETTI R., FORLI ., GALLINELLA B., GHELARDINI C., GIORDANI A., LA TORRE F., MAKOVEC F., MANETTI F., NORCINI M., PATRIGNANI P., PERGOLA C., POCE G., PORRETTA G. C., ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, SUPINO S.   +20 more
core   +1 more source

Anti‐Inflammatory Natural Products [PDF]

Mediators of Inflammation, 2015
Inflammation is the first biological response of the immune system against infection or irritation. However, accumulating epidemiological and clinical study indicates that zealous acute inflammation or chronic inflammatory reaction is a significant risk factor to develop various human diseases.
Yifu Yang, Lifei Hou, Abdelfattah El Ouaamari, Lijun Xin   +3 more
openaire   +4 more sources