Results 11 to 20 of about 1,453,982 (249)

Bidirectional Role of β2-Adrenergic Receptor in Autoimmune Diseases

Frontiers in Pharmacology, 2018
Disorder of the sympathetic nervous system (SNS) is closely related to the pathogenesis of various autoimmune diseases (ADs). Catecholamine triggered beta2-adrenergic receptor (β2-AR) signaling is important in creating a bidirectional response in the ...
Li Wu, Yu Tai, Shanshan Hu, Mei Zhang, Rui Wang, Weijie Zhou, Juan Tao, Yongsheng Han, Qingtong Wang, Wei Wei   +9 more
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IGFBP2 drives epithelial-mesenchymal transition in hepatocellular carcinoma via activating the Wnt/β-catenin pathway

Infectious Agents and Cancer, 2023
Metastasis has emerged as a major impediment to achieve successful therapeutic outcomes in hepatocellular carcinoma (HCC). Nonetheless, the intricate molecular mechanisms governing the progression of HCC remain elusive.
Xiu Chen, Yu Zhang, Pingping Zhang, Mengzhu Wei, Tian Tian, Yanling Guan, Chenchen Han, Wei Wei, Yang Ma   +8 more
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Ontogeny of Synovial Macrophages and the Roles of Synovial Macrophages From Different Origins in Arthritis

Frontiers in Immunology, 2019
The ontogeny of macrophages in most organ/tissues in human body has been proven. Due to the limited number and inaccessibility of synovial macrophages (SM), the origin of SM has not been fully illuminated.
Jiajie Tu, Wenming Hong, Wenming Hong, Yawei Guo, Pengying Zhang, Yilong Fang, Xinming Wang, Xinming Wang, Xiaoyun Chen, Shanshan Lu, Wei Wei   +10 more
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The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6′-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases

Frontiers in Pharmacology, 2019
The plant extract “total glucosides of peony” (TGP) constitutes a mixture of glycosides that is isolated from the roots of the well-known traditional Chinese herb Paeonia lactiflora Pall.
Jiajie Tu, Yawei Guo, Wenming Hong, Wenming Hong, Yilong Fang, Dafei Han, Pengying Zhang, Xinming Wang, Heinrich Körner, Wei Wei   +9 more
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NLRP3 inflammasome activation mechanism and its role in autoimmune liver disease

Acta Biochimica et Biophysica Sinica, 2022
The NLRP3 inflammasome is a multiprotein binding compound comprising NLRP3, connector protein ASC, and effector protein pro-caspase-1. When the NLRP3 inflammasome senses a danger signal from the host or pathogen, activated caspase-1 cleaves the ...
Guan Yanling, Gu Yiyue, Li Hao, Liang Bo, Han Chenchen, Zhang Yu, Liu Qian, Wei Wei, Ma Yang   +8 more
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The application of HER2 and CD47 CAR-macrophage in ovarian cancer

Journal of Translational Medicine, 2023
Background The chimeric antigen receptor (CAR)-T therapy has a limited therapeutic effect on solid tumors owing to the limited CAR-T cell infiltration into solid tumors and the inactivation of CAR-T cells by the immunosuppressive tumor microenvironment ...
Yizhao Chen, Xiangling Zhu, Hanze Liu, Cunzhi Wang, Yu Chen, Huihui Wang, Yilong Fang, Xuming Wu, Yuting Xu, Chunhua Li, Xinyue Lv, Jinghua Huang, Xintong Han, Ruilin Li, Wenming Hong, Zhiying Yu, Wei Wei, Jiajie Tu   +17 more
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Long non-coding RNAs: Potential therapeutic targets for epilepsy

Frontiers in Neuroscience, 2022
Epilepsy is a common and disastrous neurological disorder characterized by abnormal firing of neurons in the brain, affecting about 70 million people worldwide.
Sen Liu, Sen Liu, Sen Liu, Min Fan, Min Fan, Min Fan, Meng-Die Ma, Meng-Die Ma, Meng-Die Ma, Jin-Fang Ge, Jin-Fang Ge, Jin-Fang Ge, Fei-Hu Chen, Fei-Hu Chen, Fei-Hu Chen   +14 more
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The Effects of MicroRNAs on Key Signalling Pathways and Epigenetic Modification in Fibroblast-Like Synoviocytes of Rheumatoid Arthritis

Mediators of Inflammation, 2018
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level via direct binding to the 3′-untranslated region (UTR) of target mRNAs.
Wenming Hong, Pengying Zhang, Xinming Wang, Jiajie Tu, Wei Wei   +4 more
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MicroRNAs in Microglia: How do MicroRNAs Affect Activation, Inflammation, Polarization of Microglia and Mediate the Interaction Between Microglia and Glioma?

Frontiers in Molecular Neuroscience, 2019
The essential roles of microglia in maintaining homeostasis in the healthy brain and contributing to neuropathology are well documented. Emerging evidence suggests that epigenetic modulation regulates microglial behavior in both physiological and ...
Yawei Guo, Wenming Hong, Wenming Hong, Xinming Wang, Pengying Zhang, Heinrich Körner, Jiajie Tu, Wei Wei   +7 more
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Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice

Behavioral and Brain Functions, 2023
Increasing evidence has shown that the NOD-like receptor protein 1 (NLRP1) inflammasome is associated with Aβ generation and deposition, which contributes to neuronal damage and neuronal-inflammation in Alzheimer's disease (AD).
Xuewang Li, Han Zhang, Liu Yang, Xianan Dong, Yuli Han, Yong Su, Weiping Li, Weizu Li   +7 more
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