Results 11 to 20 of about 5,688,015 (387)
Are statins anti-inflammatory? [PDF]
Trials, 2000 Large scale clinical trials demonstrate significant reductions in cardiovascular event rates with statin therapy. The observed benefit of statin therapy, however, may be larger in these trials than that expected on the basis of lipid lowering alone. Emerging evidence from both clinical trials and basic science studies suggest that statins have anti ...
Blake, Gavin J., Ridker, Paul
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Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities
International Journal of Molecular Sciences, 2021 Antimicrobial peptides (AMPs) are regarded as a new generation of antibiotics. Besides antimicrobial activity, AMPs also have antibiofilm, immune-regulatory, and other activities. Exploring the mechanism of action of AMPs may help in the modification and
Ying Luo, Yuzhu Song
semanticscholar +1 more source
Pharmaceuticals, 2023 G protein-coupled receptor kinase 2 (GRK2) is one of the cytosolic enzymes, and GRK2 translocation induces prostaglandin E2 receptor 4 (EP4) over-desensitization and reduces the level of cyclic adenosine monophosphate (cAMP) to regulate macrophage ...
Jiawei Zhang +11 more
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Drug Design, Development and Therapy, 2021 Curcumin is a natural compound with great potential for disease treatment. A large number of studies have proved that curcumin has a variety of biological activities, among which anti-inflammatory effect is a significant feature of it.
Ying Peng +7 more
semanticscholar +1 more source
Genistein: A Review on its Anti-Inflammatory Properties
Frontiers in Pharmacology, 2022 Nowadays, non-resolving inflammation is becoming a major trigger in various diseases as it plays a significant role in the pathogenesis of atherosclerosis, asthma, cancer, obesity, inflammatory bowel disease, chronic obstructive pulmonary disease ...
Yu Xian Goh +4 more
semanticscholar +1 more source
Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment
Clinical Rheumatology, 2020 COVID-19 infection has a heterogenous disease course; it may be asymptomatic or causes only mild symptoms in the majority of the cases, while immunologic complications such as macrophage activation syndrome also known as secondary hemophagocytic ...
M. Soy +5 more
semanticscholar +1 more source
New insights into the Lck-NF-κB signaling pathway
Frontiers in Cell and Developmental Biology, 2023 Lck is essential for the development, activity, and proliferation of T cells, which may contribute to pathological progression and development of human diseases, such as autoimmune disorders and cancers when functioning aberrantly.
Jing Zhang +4 more
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Pharmaceutical Biology, 2020 Context Ginsenoside compound K (CK) has anti-inflammatory, immunoregulatory, and myelosuppressive protective effects. Methotrexate (MTX) is widely used in combination therapy for rheumatoid arthritis (RA). Objective To evaluate the effects of combination
Jingyu Chen +4 more
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The anti-inflammatory mechanisms of Hsp70 [PDF]
Frontiers in Immunology, 2012 Immune responses to heat shock proteins (Hsp) develop in virtually all inflammatory diseases; however, the significance of such responses is only now becoming clear. In experimental disease models, Hsp administration can prevent or arrest inflammatory damage, and in initial clinical trials in patients with chronic inflammatory diseases, Hsp peptides ...
Borges, T.J. +6 more
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Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases
Frontiers in Pharmacology, 2018 The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the progression of the immune response including autoimmune diseases. Antigen presentation on immune cell surface, formation of an immunological synapse (IS),
Yu Tai +5 more
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