Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future
Mediators of Inflammation, 2020 The ontogeny of macrophages in most organs has already been established. Owing to the limited number and inaccessibility of synovial macrophages (SMs), the origin of SMs has not been fully elucidated.
Jiajie Tu +7 more
doaj +1 more source
Immune-Cell-Based Therapy for COVID-19: Current Status
Viruses, 2023 Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. The interplay between innate and adaptive immune responses plays a crucial role in managing COVID-19.
Yiyuan Wang +7 more
doaj +1 more source
International Journal of Molecular Sciences, 2022 Since chronic inflammation can be seen in severe, long-lasting diseases such as cancer, there is a high demand for effective methods to modulate inflammatory responses.
Won Young Jang, Mi-Yeon Kim, J. Cho
semanticscholar +1 more source
The glucocorticoid receptor in inflammatory processes : transrepression is not enough [PDF]
, 2015 Glucocorticoids (GCs) are the most commonly used anti-inflammatory agents to treat inflammatory and immune diseases. However, steroid therapies are accompanied by severe side-effects during long-term treatment. The dogma that transrepression of genes, by
Dejager, Lien +3 more
core +2 more sources
Bidirectional Role of β2-Adrenergic Receptor in Autoimmune Diseases
Frontiers in Pharmacology, 2018 Disorder of the sympathetic nervous system (SNS) is closely related to the pathogenesis of various autoimmune diseases (ADs). Catecholamine triggered beta2-adrenergic receptor (β2-AR) signaling is important in creating a bidirectional response in the ...
Li Wu +9 more
doaj +1 more source
Simvastatin inhibits TLR8 signaling in primary human monocytes and spontaneous TNF production from rheumatoid synovial membrane cultures [PDF]
, 2015 Simvastatin has been shown to have anti-inflammatory effects that are independent of its serum cholesterol lowering action, but the mechanisms by which these anti-inflammatory effects are mediated have not been elucidated.
A Gierut +48 more
core +1 more source
Anti‐Inflammatory Natural Products [PDF]
Mediators of Inflammation, 2015 Inflammation is the first biological response of the immune system against infection or irritation. However, accumulating epidemiological and clinical study indicates that zealous acute inflammation or chronic inflammatory reaction is a significant risk factor to develop various human diseases.
Yifu Yang +3 more
openaire +4 more sources
Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. [PDF]
, 2008 Following our previous research on anti-inflammatory drugs (NSAIDs), we report here the synthesis of chiral 1,5-diarylpyrroles derivatives that were characterized for their in vitro inhibitory effects toward cyclooxygenase (COX) isozymes.
ANZELLOTTI P. +20 more
core +1 more source
Nicotine in Inflammatory Diseases: Anti-Inflammatory and Pro-Inflammatory Effects
Frontiers in Immunology, 2022 As an anti-inflammatory alkaloid, nicotine plays dual roles in treating diseases. Here we reviewed the anti-inflammatory and pro-inflammatory effects of nicotine on inflammatory diseases, including inflammatory bowel disease, arthritis, multiple ...
Wenji Zhang +6 more
semanticscholar +1 more source
Infectious Agents and Cancer, 2023 Metastasis has emerged as a major impediment to achieve successful therapeutic outcomes in hepatocellular carcinoma (HCC). Nonetheless, the intricate molecular mechanisms governing the progression of HCC remain elusive.
Xiu Chen +8 more
doaj +1 more source