Bidirectional Role of β2-Adrenergic Receptor in Autoimmune Diseases
Frontiers in Pharmacology, 2018 Disorder of the sympathetic nervous system (SNS) is closely related to the pathogenesis of various autoimmune diseases (ADs). Catecholamine triggered beta2-adrenergic receptor (β2-AR) signaling is important in creating a bidirectional response in the ...
Li Wu +9 more
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Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection [PDF]
, 2015 Bioactive matrix fragments (matrikines) have been identified in a myriad of disorders, but their impact on the evolution of airway inflammation has not been demonstrated.
Snelgrove, RJ
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Chenopodin as an anti-inflammatory compound
Natural Product Research, 2021 Chenopodin is an 11S-type globulin purified from Chenopodium quinoa seeds, which can bind carbohydrates and hemagglutinating human erythrocytes. The present study aimed to evaluate the N-terminal structure of the heterodimeric Chenopodin and its effects in models of inflammation.
Renes R. Machado +10 more
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Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. [PDF]
, 2011 Based on its capacity to inhibit in vitro HIV-1 replication in T cells and the release of pro-inflammatory cytokines in monocytes, the prenylated heterodimeric phloroglucinyl α-pyrone arzanol was identified as the major anti-inflammatory and anti-viral ...
Appendino G +8 more
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NLRP3 inflammasome activation mechanism and its role in autoimmune liver disease
Acta Biochimica et Biophysica Sinica, 2022 The NLRP3 inflammasome is a multiprotein binding compound comprising NLRP3, connector protein ASC, and effector protein pro-caspase-1. When the NLRP3 inflammasome senses a danger signal from the host or pathogen, activated caspase-1 cleaves the ...
Guan Yanling +8 more
doaj +1 more source
CXCL16/CXCR6 axis drives microglia/macrophages phenotype in physiological conditions and plays a crucial role in glioma [PDF]
, 2018 Microglia are patrolling cells that sense changes in the brain microenvironment and respond acquiring distinct phenotypes that can be either beneficial or detrimental for brain homeostasis.
Antonangeli, Fabrizio +6 more
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Infectious Agents and Cancer, 2023 Metastasis has emerged as a major impediment to achieve successful therapeutic outcomes in hepatocellular carcinoma (HCC). Nonetheless, the intricate molecular mechanisms governing the progression of HCC remain elusive.
Xiu Chen +8 more
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Pharmacological Research, 2023 T-cell acute lymphoblastic leukemia (T-ALL) has a poor prognosis as a result of severe immunosuppression and rapid tumor progression with resistance to conventional chemotherapy.
Yujing Wu +11 more
doaj +1 more source
Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]
, 2012 Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A. +3 more
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Anti‐inflammatory actions of acupuncture [PDF]
Mediators of Inflammation, 2003 Acupuncture has a beneficial effect when treating many diseases and painful conditions, and therefore is thought to be useful as a complementary therapy or to replace generally accepted pharmacological intervention. The attributive effect of acupuncture has been investigated in inflammatory diseases, including asthma, rhinitis, inflammatory bowel ...
Jan Klein +3 more
openaire +4 more sources