Results 21 to 30 of about 5,289,236 (296)

New insights into the Lck-NF-κB signaling pathway

Frontiers in Cell and Developmental Biology, 2023
Lck is essential for the development, activity, and proliferation of T cells, which may contribute to pathological progression and development of human diseases, such as autoimmune disorders and cancers when functioning aberrantly.
Jing Zhang, Jing Zhang, Yu-Jing Wu, Xiao-Xi Hu, Wei Wei   +4 more
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Combination therapy of ginsenoside compound K and methotrexate was efficient in elimination of anaemia and reduction of disease activity in adjuvant-induced arthritis rats

Pharmaceutical Biology, 2020
Context Ginsenoside compound K (CK) has anti-inflammatory, immunoregulatory, and myelosuppressive protective effects. Methotrexate (MTX) is widely used in combination therapy for rheumatoid arthritis (RA). Objective To evaluate the effects of combination
Jingyu Chen, Wu Wang, Mengya Jiang, Mei Yang, Wei Wei   +4 more
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Antioxidant, Anti-Inflammatory, Anti-Menopausal, and Anti-Cancer Effects of Lignans and Their Metabolites

International Journal of Molecular Sciences, 2022
Since chronic inflammation can be seen in severe, long-lasting diseases such as cancer, there is a high demand for effective methods to modulate inflammatory responses.
Won Young Jang, Mi-Yeon Kim, J. Cho
semanticscholar   +1 more source

Recent Update on the Anti-Inflammatory Activities of Propolis

Molecules, 2022
In recent years, research has demonstrated the efficacy propolis as a potential raw material for pharmaceuticals and nutraceuticals. There is limited report detailing the mechanisms of action of propolis and its bioactive compounds in relation to their ...
F. Zulhendri, R. Lesmana, S. Tandean, A. Christoper, Kavita Chandrasekaran, I. Irsyam, A. Suwantika, R. Abdulah, Nasrul Wathoni   +8 more
semanticscholar   +1 more source

Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases

Frontiers in Pharmacology, 2018
The interaction between T cell and dendritic cells (DCs) that leads to T cell activation affects the progression of the immune response including autoimmune diseases. Antigen presentation on immune cell surface, formation of an immunological synapse (IS),
Yu Tai, Qingtong Wang, Heinrich Korner, Heinrich Korner, Lingling Zhang, Wei Wei   +5 more
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Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats

Acta Pharmaceutica Sinica B, 2021
Rheumatoid arthritis (RA) is an autoimmune disease and is mainly characterized by abnormal proliferation of fibroblast-like synoviocytes (FLS). The up-regulated cellular membrane expression of G protein coupled receptor kinase 2 (GRK2) of FLS plays a ...
Chenchen Han, Yifan Li, Yuwen Zhang, Yang Wang, Dongqian Cui, Tingting Luo, Yu Zhang, Qian Liu, Hao Li, Chun Wang, Dexiang Xu, Yang Ma, Wei Wei   +12 more
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The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6′-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases

Frontiers in Pharmacology, 2019
The plant extract “total glucosides of peony” (TGP) constitutes a mixture of glycosides that is isolated from the roots of the well-known traditional Chinese herb Paeonia lactiflora Pall.
Jiajie Tu, Yawei Guo, Wenming Hong, Wenming Hong, Yilong Fang, Dafei Han, Pengying Zhang, Xinming Wang, Heinrich Körner, Wei Wei   +9 more
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Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future

Mediators of Inflammation, 2020
The ontogeny of macrophages in most organs has already been established. Owing to the limited number and inaccessibility of synovial macrophages (SMs), the origin of SMs has not been fully elucidated.
Jiajie Tu, Xinming Wang, Xun Gong, Wenming Hong, Dafei Han, Yilong Fang, Yawei Guo, Wei Wei   +7 more
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Ontogeny of Synovial Macrophages and the Roles of Synovial Macrophages From Different Origins in Arthritis

Frontiers in Immunology, 2019
The ontogeny of macrophages in most organ/tissues in human body has been proven. Due to the limited number and inaccessibility of synovial macrophages (SM), the origin of SM has not been fully illuminated.
Jiajie Tu, Wenming Hong, Wenming Hong, Yawei Guo, Pengying Zhang, Yilong Fang, Xinming Wang, Xinming Wang, Xiaoyun Chen, Shanshan Lu, Wei Wei   +10 more
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IgD/FcδR is involved in T-cell acute lymphoblastic leukemia and regulated by IgD-Fc-Ig fusion protein

Pharmacological Research, 2023
T-cell acute lymphoblastic leukemia (T-ALL) has a poor prognosis as a result of severe immunosuppression and rapid tumor progression with resistance to conventional chemotherapy.
Yujing Wu, Aijun Zhang, Wensheng Chen, Qianling Xin, Wenwen Pan, Xiaoxi Hu, Tao Li, Hengshi Chen, Jing Zhang, Chengxin Luan, Jian Ge, Wei Wei   +11 more
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