Results 31 to 40 of about 5,289,236 (296)
Nicotine in Inflammatory Diseases: Anti-Inflammatory and Pro-Inflammatory Effects
Frontiers in Immunology, 2022 As an anti-inflammatory alkaloid, nicotine plays dual roles in treating diseases. Here we reviewed the anti-inflammatory and pro-inflammatory effects of nicotine on inflammatory diseases, including inflammatory bowel disease, arthritis, multiple ...
Wenji Zhang +6 more
semanticscholar +1 more source
Infectious Agents and Cancer, 2023 Metastasis has emerged as a major impediment to achieve successful therapeutic outcomes in hepatocellular carcinoma (HCC). Nonetheless, the intricate molecular mechanisms governing the progression of HCC remain elusive.
Xiu Chen +8 more
doaj +1 more source
NLRP3 inflammasome activation mechanism and its role in autoimmune liver disease
Acta Biochimica et Biophysica Sinica, 2022 The NLRP3 inflammasome is a multiprotein binding compound comprising NLRP3, connector protein ASC, and effector protein pro-caspase-1. When the NLRP3 inflammasome senses a danger signal from the host or pathogen, activated caspase-1 cleaves the ...
Guan Yanling +8 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2019 The essential roles of microglia in maintaining homeostasis in the healthy brain and contributing to neuropathology are well documented. Emerging evidence suggests that epigenetic modulation regulates microglial behavior in both physiological and ...
Yawei Guo +7 more
doaj +1 more source
Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body
Frontiers in Immunology, 2021 Hosting millions of microorganisms, the digestive tract is the primary and most important part of bacterial colonization. On one side, in cases of opportunistic invasion, the abundant bacterial population inside intestinal tissues may face potential ...
F. Cristofori +5 more
semanticscholar +1 more source
Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties
Antioxidants, 2021 Oxidative stress and inflammation triggered by increased oxidative stress are the cause of many chronic diseases. The lack of anti-inflammatory drugs without side-effects has stimulated the search for new active substances.
M. Bucciantini +4 more
semanticscholar +1 more source
Frontiers in Immunology, 2018 Fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS) are the two main cellular components of the synovium. It has been widely reported that FLS and MLS play essential roles in the joint pathology of rheumatoid arthritis (RA ...
Jiajie Tu +7 more
doaj +1 more source
Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice
Behavioral and Brain Functions, 2023 Increasing evidence has shown that the NOD-like receptor protein 1 (NLRP1) inflammasome is associated with Aβ generation and deposition, which contributes to neuronal damage and neuronal-inflammation in Alzheimer's disease (AD).
Xuewang Li +7 more
doaj +1 more source
The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis
Mediators of Inflammation, 2020 Collagen triple helix repeat containing-1 (CTHRC1) has been identified as cancer-related protein. CTHRC1 expresses mainly in adventitial fibroblasts and neointimal smooth muscle cells of balloon-injured vessels and promotes cell migration and tissue ...
Dan Mei +3 more
doaj +1 more source
The application of HER2 and CD47 CAR-macrophage in ovarian cancer
Journal of Translational Medicine, 2023 Background The chimeric antigen receptor (CAR)-T therapy has a limited therapeutic effect on solid tumors owing to the limited CAR-T cell infiltration into solid tumors and the inactivation of CAR-T cells by the immunosuppressive tumor microenvironment ...
Yizhao Chen +17 more
doaj +1 more source