Results 31 to 40 of about 1,414,086 (297)

The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis

Mediators of Inflammation, 2020
Collagen triple helix repeat containing-1 (CTHRC1) has been identified as cancer-related protein. CTHRC1 expresses mainly in adventitial fibroblasts and neointimal smooth muscle cells of balloon-injured vessels and promotes cell migration and tissue ...
Dan Mei, Yue Zhu, Lingling Zhang, Wei Wei   +3 more
doaj   +1 more source

Long non-coding RNAs: Potential therapeutic targets for epilepsy

Frontiers in Neuroscience, 2022
Epilepsy is a common and disastrous neurological disorder characterized by abnormal firing of neurons in the brain, affecting about 70 million people worldwide.
Sen Liu, Sen Liu, Sen Liu, Min Fan, Min Fan, Min Fan, Meng-Die Ma, Meng-Die Ma, Meng-Die Ma, Jin-Fang Ge, Jin-Fang Ge, Jin-Fang Ge, Fei-Hu Chen, Fei-Hu Chen, Fei-Hu Chen   +14 more
doaj   +1 more source

The application of HER2 and CD47 CAR-macrophage in ovarian cancer

Journal of Translational Medicine, 2023
Background The chimeric antigen receptor (CAR)-T therapy has a limited therapeutic effect on solid tumors owing to the limited CAR-T cell infiltration into solid tumors and the inactivation of CAR-T cells by the immunosuppressive tumor microenvironment ...
Yizhao Chen, Xiangling Zhu, Hanze Liu, Cunzhi Wang, Yu Chen, Huihui Wang, Yilong Fang, Xuming Wu, Yuting Xu, Chunhua Li, Xinyue Lv, Jinghua Huang, Xintong Han, Ruilin Li, Wenming Hong, Zhiying Yu, Wei Wei, Jiajie Tu   +17 more
doaj   +1 more source

The role of a key transcription factor PU.1 in autoimmune diseases

Frontiers in Immunology, 2022
PU.1, a transcription factor member of the E26 transformation-specific family, affects the function of a variety of immune cells in several physiological and pathological conditions.
Yilong Fang, Weile Chen, Zhe Li, Yu Chen, Xuming Wu, Xiangling Zhu, Huihui Wang, Xiaochun Chen, Qiuni Liang, Jinghua Huang, Xintong Han, Wenming Hong, Xinming Wang, Wei Wei, Zhiying Yu, Jiajie Tu   +15 more
doaj   +1 more source

The Effects of Crocin on Bone and Cartilage Diseases

Frontiers in Pharmacology, 2022
Crocin, the main biologically active carotenoid of saffron, generally is derived from the dried trifid stigma of Crocus sativus L. Many studies have demonstrated that crocin has several therapeutic effects on biological systems through its anti-oxidant ...
Shayan Vafaei, Xuming Wu, Jiajie Tu, Seyed Noureddin Nematollahi-mahani   +3 more
doaj   +1 more source

Anti-inflammatory Effects of Phosphatidylcholine [PDF]

Journal of Biological Chemistry, 2007
We recently showed that mucus from patients with ulcerative colitis, a chronic inflammatory disorder of the colon, is characterized by a low level of phosphatidylcholine (PC) while clinical studies reveal that therapeutic addition of PC using slow release preparations is beneficial. The positive role of PC in this disease is still elusive.
Treede, Irina, Braun, Annika, Sparla, Richard, Kuehnel, Mark, Giese, Thomas, Turner, Jerrold R., Anes, Elsa, Kulaksiz, Hasan, Fuellekrug, Joachim, Stremmel, Wolfgang, Griffiths, Gareth, Ehehalt, Robert   +11 more
openaire   +4 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

CP-25 ameliorates methotrexate induced nephrotoxicity via improving renal apoptosis and methotrexate excretion

Journal of Pharmacological Sciences, 2021
Paeoniflorin-6′-O-benzene sulfonate (CP-25) is a derivative of Paeoniflorin. We investigate beneficial effect of CP-25 on methotrexate (MTX) induced nephrotoxicity in rats.
Xiao Wei, Yijin Wu, Hao Tang, Bin Wang, Yong Wang, Wei Sun, James Asenso, Feng Xiao, Chun Wang   +8 more
doaj  

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source