Results 81 to 90 of about 901,503 (311)

Dual Anti-Inflammatory and Anti-Angiogenic Action of miR-15a in Diabetic Retinopathy

EBioMedicine, 2016
Activation of pro-inflammatory and pro-angiogenic pathways in the retina and the bone marrow contributes to pathogenesis of diabetic retinopathy. We identified miR-15a as key regulator of both pro-inflammatory and pro-angiogenic pathways through direct ...
Qi Wang, Svetlana Navitskaya, Harshini Chakravarthy, Chao Huang, Nermin Kady, Todd A. Lydic, Y. Eugene Chen, Ke-Jie Yin, Folami Lamoke Powell, Pamela M. Martin, Maria B. Grant, Julia V. Busik   +11 more
doaj   +1 more source

The Anti-inflammatory Actions of Tilorone Hydrochloride

Experimental Biology and Medicine, 1975
Tilorone suppressed inflammation induced by immune (direct passive Arthus reaction) as well as by non-immune agents (carrageenam-induced paw edema and abscess formation), if the compound is given 24 hr prior to the proinflammatory agonists. The non-immune anti-inflammatory effect is independent of the adrenals.
H, Megel, A, Raychaudhuri, I, Shemano, T H, Beaver, L L, Thomas   +4 more
openaire   +2 more sources

HGF Mediates the Anti-inflammatory Effects of PRP on Injured Tendons [PDF]

, 2013
Platelet-rich plasma (PRP) containing hepatocyte growth factor (HGF) and other growth factors are widely used in orthopaedic/sports medicine to repair injured tendons.
A Mishra, A Schneider, AR Amin, B Christensen, B Christensen, BA Kerr, C Gabay, C Hsu, C Molnar, Cristoforo Scavone, DL Butler, DW Gilroy, DW Gilroy, E Anitua, E Homsi, F Cilli, Freddie H. Fu, G Yang, H El-Sharkawy, Hee-Jeong Im, J Damm, J Zhang, J Zhang, J Zhang, J Zhang, James H-C. Wang, JC Peerbooms, JC Peerbooms, JH Wang, JH Wang, Jianying Zhang, K Takai, Kellie K. Middleton, KM Khan, L Engebretsen, LC Almekinders, M Giannopoulou, M Okada, M Tsuzaki, MH Khan, MM Murray, MM Murray, MM Wolfe, P Bendinelli, P Renstrom, R Gong, RE Marx, RJ de Vos, S Fiorucci, S Nakamura, S Narumiya, SH Ferreira, ST Ferry, T Kaido, T Molloy, TE Foster, TJ Williams, U Sheth, UC Kopp, WL Smith, YH Kang, Z Li   +61 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Synthesis, characterization and anti-inflammatory evaluation of novel derivatives of Trolox with pharmacological alcohol and amines

Bulletin of the Chemical Society of Ethiopia, 2017
In order to explore the novel anti-inflammatory agents, some novel Trolox derivatives were synthesized and characterized by IR, 1H-NMR, 13C-NMR, mass and elemental analysis.
A. Ahmadi
doaj   +1 more source

Paricalcitol reduces oxidative stress and inflammation in hemodialysis patients [PDF]

, 2012
Background: Treatment with selective vitamin D receptor activators such as paricalcitol have been shown to exert an anti-inflammatory effect in patients on hemodialysis, in addition to their action on mineral metabolism and independently of parathyroid
A Levin, AJ Claiborne, Angel LM de Francisco, AT Peres, B Gonzalez-Diez, B Gonzalez-Diez, BP Oberg, C Antoniades, CC Wu, D Coyne, D Grotto, DL Andress, E Alegre, F Baeke, F Locatelli, G Clermont, GJ Handelman, H Miyazaki, H Moshage, J Galle, J Himmelfarb, J Juan Navarro-González, J Lindberg, J Nourooz-Zadeh, Javier Santos, JC Schefold, JL Finch, JL Gamboa, JM McCord, K Husain, K Husain, K Pawlak, K Pawlak, M Dirican, M Morena, M Takeda, M Tanaka, Manuel Arias, María Jesús Izquierdo, Mónica Cavia, N Mittman, O Ziouzenkova, OH Lowry, P Alborzi, Pedro Abaigar, Pilar Muñiz, R Brigelius, RJ Lund, RL Levine, S Mathew, SE Judd, SE Judd, SM Sprague, SN Chugh, T Eleftheriadis, T Zitman-Gal, X Guillot, X Tan   +57 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Role of Bifidobacterium bifidum and plant food extracts in improving microflora and biochemical and cytogenetic parameters in adjuvant arthritis. [PDF]

, 2011
The aim of the present research was to discover plant food extracts and probiotics that may have bioactivity towards chronic inflammation. Three plant food extract mixtures expected to be rich in phenolic compounds, carotenoids and tocopherols were ...
Abd El Khalek, A. B., Al-Okbi, S. Y., Donya, S. M., Mohamed, D. A.   +3 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Mechanisms Behind the Anti-inflammatory Actions of Insulin

Critical Reviews™ in Immunology, 2011
The epidemic of diabetes mellitus is worsening worldwide. Diabetes mellitus is a chronic metabolic disease characterized by inappropriate recurrent or persistent hyperglycemia. Numerous studies have demonstrated that hyperglycemia, the most significant predictor of poor clinical outcome in diabetes mellitus patients, can directly promote an ...
Hyun, Eric, Ramachandran, Rithwik, Hollenberg, Morley D., Vergnolle, Nathalie   +3 more
openaire   +4 more sources