Results 81 to 90 of about 7,096,396 (300)

Synthesis, characterization and anti-inflammatory evaluation of novel derivatives of Trolox with pharmacological alcohol and amines

Bulletin of the Chemical Society of Ethiopia, 2017
In order to explore the novel anti-inflammatory agents, some novel Trolox derivatives were synthesized and characterized by IR, 1H-NMR, 13C-NMR, mass and elemental analysis.
A. Ahmadi
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Anti-inflammatory Cytokines and Depression

, 2014
In recent years, the cytokine hypothesis of depression has received considerable research attention, providing insights on the mechanism study and the therapeutic treatment of depressive disorders. Two classes of cytokines, pro-inflammatory cytokines and
Lin Wen-Juan, Xu Yue
core  

Cyclopentenone prostaglandins as anti-inflammatory agents: a novel therapeutic strategy.

, 2003
Cyclopentenone prostaglandins (cyPG) are naturally occurring derivatives of prostaglandin E1, E2, and D2 containing an α,β-unsaturated carbonyl group in the cyclopentane ring structure (cyclopentenone).
IANARO, ANGELA, MAFFIA P, IALENTI, ARMANDO, DI ROSA M, Rosa, M., Maffia, P., Ianaro, A., Ialenti, A., A. Ianaro, P. Maffia, M. Rosa, A. Ialenti   +11 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Natural Xanthones and Skin Inflammatory Diseases: Multitargeting Mechanisms of Action and Potential Application

Frontiers in Pharmacology, 2020
The pathogenesis of skin inflammatory diseases such as atopic dermatitis, acne, psoriasis, and skin cancers generally involve the generation of oxidative stress and chronic inflammation. Exposure of the skin to external aggressors such as ultraviolet (UV)
Natalie Vivien Gunter, Soek Sin Teh, Yang Mooi Lim, Yang Mooi Lim, Siau Hui Mah, Siau Hui Mah   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A3 Adenosine Receptor Allosteric Modulator Induces an Anti-Inflammatory Effect: In Vivo Studies and Molecular Mechanism of Action

Mediators of Inflammation, 2014
The A3 adenosine receptor (A3AR) is overexpressed in inflammatory cells and in the peripheral blood mononuclear cells of individuals with inflammatory conditions.
Shira Cohen, Faina Barer, Sara Bar-Yehuda, Adriaan P. IJzerman, Kenneth A. Jacobson, Pnina Fishman   +5 more
doaj   +1 more source

Dual Anti-Inflammatory and Anti-Angiogenic Action of miR-15a in Diabetic Retinopathy

EBioMedicine, 2016
Activation of pro-inflammatory and pro-angiogenic pathways in the retina and the bone marrow contributes to pathogenesis of diabetic retinopathy. We identified miR-15a as key regulator of both pro-inflammatory and pro-angiogenic pathways through direct ...
Qi Wang, Svetlana Navitskaya, Harshini Chakravarthy, Chao Huang, Nermin Kady, Todd A. Lydic, Y. Eugene Chen, Ke-Jie Yin, Folami Lamoke Powell, Pamela M. Martin, Maria B. Grant, Julia V. Busik   +11 more
doaj   +1 more source

Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation [PDF]

, 2012
The recruitment of T lymphocytes during diseases such as rheumatoid arthritis is regulated by stimulation of the chemokine receptors expressed by these cells.
O'Boyle, Graeme, Palmer, Jeremy, Mavin, Emily, Kirby, John, Hine, Dominic, Barker, Catriona, Ali, Simi, Lamb, Christopher, Willet, Joseph, Fox, Christopher, Walden, Hannah   +10 more
core   +1 more source