The Possible Role of Anti-Neu5Gc as an Obstacle in Xenotransplantation [PDF]
Frontiers in Immunology, 2020 Seventy to ninety percentage of preformed xenoreactive antibodies in human serum bind to the galactose-α(1,3)-galactose Gal epitope, and the creation of Gal knockout (KO) pigs has eliminated hyperacute rejection as a barrier to xenotransplantation.
Alfred Joseph Tector +3 more
doaj +9 more sources
Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans. [PDF]
PLoS ONE, 2017 Our group previously investigated the levels of anti-Gal and anti-nonGal IgM and IgG in a cohort of 75 healthy humans of various backgrounds, and found some significant differences related to factors such as age, gender, ABO blood group, diet ...
Bingsi Gao +11 more
doaj +7 more sources
Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans—An Evolutionary Perspective [PDF]
Frontiers in Immunology, 2019 The glycocalyx of human cells differs from that of many other mammals by the lack of the sialic acid N-glycolylneuraminic acid (Neu5Gc) and increased abundance of its precursor N-acetylneuraminic acid (Neu5Ac).
Meghan O. Altman +2 more
doaj +9 more sources
A simple method for assessment of human anti-Neu5Gc antibodies applied to Kawasaki disease. [PDF]
PLoS ONE, 2013 N-glycolylneuraminic acid (Neu5Gc) is an immunogenic sugar of dietary origin that metabolically incorporates into diverse native glycoconjugates in humans.
Vered Padler-Karavani +5 more
doaj +9 more sources
Challenging the Role of Diet-Induced Anti-Neu5Gc Antibodies in Human Pathologies [PDF]
Frontiers in Immunology, 2020 No abstract ...
Jean-Paul Soulillou +2 more
doaj +9 more sources
Exposure of Children to Rural Lifestyle Factors Associated With Protection Against Allergies Induces an Anti-Neu5Gc Antibody Response [PDF]
Frontiers in Immunology, 2019 Rural lifestyle has been shown to be highly protective against the development of allergies. Contact to farm-animals or pets and early-life consumption of milk products turned out to be important.
Remo Frei +9 more
doaj +8 more sources
Generation of Cloned Sheep Lacking Galactose-α1,3-Galactose and N-Glycolylneuraminic Acid Antigens. [PDF]
XenotransplantationABSTRACT Livestock have long been regarded as a potential source of donor organs to alleviate the global organ shortage for transplantation. Sheep have a similar anatomy to humans, providing the standard model for demonstrating biocompatibility and performance of biological heart valves to obtain regulatory approval for their use in transplantation ...
Appleby SJ +9 more
europepmc +2 more sources
Frontiers in Immunology, 2019 The description of “serum sickness” more than a century ago in humans transfused with animal sera eventually led to identification of a class of human antibodies directed against glycans terminating in the common mammalian sialic acid N ...
Chirag Dhar +5 more
doaj +3 more sources
N-Glycolylneuraminic Acid (Neu5Gc) Null Large Animals by Targeting the CMP-Neu5Gc Hydroxylase (CMAH)
Frontiers in Immunology, 2019 The two major sialic acids described in mammalian cells are the N-glycolylneuraminic acid (Neu5Gc) and the N-acetylneuraminic acid (Neu5Ac). Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group ...
Andrea Perota +2 more
doaj +3 more sources
Frontiers in Molecular BiosciencesDespite an array of hypothesised implications for health, disease, and therapeutic development, antibodies against the non-human sialic acid N-glycolylneuraminic acid (Neu5Gc) remain a subject of much debate.
Esme Hutton +5 more
doaj +3 more sources