Results 31 to 40 of about 1,812 (120)

The Structural Complexity and Animal Tissue Distribution of N-Glycolylneuraminic Acid (Neu5Gc)-Terminated Glycans. Implications for Their Immunogenicity in Clinical Xenografting

Frontiers in Molecular Biosciences, 2019
N-Glycolylneuraminic acid (Neu5Gc)-terminated glycans are present in all animal cells/tissues that are already used in the clinic such as bioprosthetic heart valves (BHV) as well as in those that potentially will be xenografted in the future to overcome ...
Michael E. Breimer, Jan Holgersson
doaj   +1 more source

New Insights into Xenotransplantation for Cartilage Repair: Porcine Multi-Genetically Modified Chondrocytes as a Promising Cell Source

Cells, 2021
Transplantation of xenogenic porcine chondrocytes could represent a future strategy for the treatment of human articular cartilage defects. Major obstacles are humoral and cellular rejection processes triggered by xenogenic epitopes like α-1,3-Gal and ...
Hanna Tritschler, Konrad Fischer, Jochen Seissler, Jörg Fiedler, Rebecca Halbgebauer, Markus Huber-Lang, Angelika Schnieke, Rolf E. Brenner   +7 more
doaj   +1 more source

Anti-EBOV GP IgGs Lacking α1-3-Galactose and Neu5Gc Prolong Survival and Decrease Blood Viral Load in EBOV-Infected Guinea Pigs. [PDF]

PLoS ONE, 2016
Polyclonal xenogenic IgGs, although having been used in the prevention and cure of severe infectious diseases, are highly immunogenic, which may restrict their usage in new applications such as Ebola hemorrhagic fever.
Olivier Reynard, Frédéric Jacquot, Gwénaëlle Evanno, Hoa Le Mai, Apolline Salama, Bernard Martinet, Odile Duvaux, Jean-Marie Bach, Sophie Conchon, Jean-Paul Judor, Andrea Perota, Irina Lagutina, Roberto Duchi, Giovanna Lazzari, Ludmilla Le Berre, Hélène Perreault, Elsa Lheriteau, Hervé Raoul, Viktor Volchkov, Cesare Galli, Jean-Paul Soulillou   +20 more
doaj   +1 more source

Both Natural and Induced Anti-Sda Antibodies Play Important Roles in GTKO Pig-to-Rhesus Monkey Xenotransplantation

Frontiers in Immunology, 2022
Sda, produced by the B4GALNT2 enzyme, has been recognized as an important xenoantigen for pig-to-nonhuman primate xenotransplantation. However, little is known about Sda expression in pigs and its immunogenicity in xenotransplantation.
Hao Feng, Hao Feng, Tao Li, Jiaxiang Du, Qiangbing Xia, Qiangbing Xia, Lu Wang, Lu Wang, Song Chen, Song Chen, Lan Zhu, Lan Zhu, Dengke Pan, Yi Wang, Gang Chen, Gang Chen   +15 more
doaj   +1 more source

Involvement of a Non-Human Sialic Acid in Human Cancer

Frontiers in Oncology, 2014
Sialic acids are common monosaccharides that are widely expressed as outer terminal units on all vertebrate cell surfaces, and play fundamental roles in cell-cell and cell-microenvironment interactions.
Annie eSamraj, Heinz eLäubli, Nissi eVarki, Ajit eVarki   +3 more
doaj   +1 more source

Current Topics of Relevance to the Xenotransplantation of Free Pig Islets

Frontiers in Immunology, 2022
Pig islet xenotransplantation is a potential treatment for patients with type 1 diabetes. Current efforts are focused on identifying the optimal pig islet source and overcoming the immunological barrier.
Lisha Mou, Lisha Mou, Guanghan Shi, Guanghan Shi, David K.C. Cooper, Ying Lu, Jiao Chen, Shufang Zhu, Jing Deng, Yuanyuan Huang, Yong Ni, Yongqiang Zhan, Zhiming Cai, Zuhui Pu   +13 more
doaj   +1 more source

Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk.

PLoS ONE, 2018
BackgroundN-glycolylneuraminic acid (Neu5Gc) is a non-human red-meat-derived sialic acid immunogenic to humans. Neu5Gc can be metabolically incorporated into glycan chains on human endothelial and epithelial surfaces. This represents the first example of
Annie N Samraj, Kimberly A Bertrand, Robert Luben, Zahra Khedri, Hai Yu, Dzung Nguyen, Christopher J Gregg, Sandra L Diaz, Sherilyn Sawyer, Xi Chen, Heather Eliassen, Vered Padler-Karavani, Kana Wu, Kay-Tee Khaw, Walter Willett, Ajit Varki   +15 more
doaj   +1 more source

LIS1, a glyco-humanized swine polyclonal anti-lymphocyte globulin, as a novel induction treatment in solid organ transplantation

Frontiers in Immunology, 2023
Anti-thymocyte or anti-lymphocyte globulins (ATGs/ALGs) are immunosuppressive drugs used in induction therapies to prevent acute rejection in solid organ transplantation.
Juliette Rousse, Pierre-Joseph Royer, Gwénaëlle Evanno, Elsa Lheriteau, Carine Ciron, Apolline Salama, Françoise Shneiker, Roberto Duchi, Andrea Perota, Cesare Galli, Emmanuele Cozzi, Gilles Blancho, Odile Duvaux, Sophie Brouard, Jean-Paul Soulillou, Jean-Marie Bach, Bernard Vanhove   +16 more
doaj   +1 more source

Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products.

PLoS ONE, 2009
BackgroundHumans are genetically defective in synthesizing the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc), but can metabolically incorporate it from dietary sources (particularly red meat and milk) into glycoproteins and glycolipids ...
Sandra L Diaz, Vered Padler-Karavani, Darius Ghaderi, Nancy Hurtado-Ziola, Hai Yu, Xi Chen, Els C M Brinkman-Van der Linden, Ajit Varki, Nissi M Varki   +8 more
doaj   +1 more source

The Role of Non-Human Sialic Acid Neu5Gc-Containing Glycoconjugates in Human Tumors: A Review of Clinical and Experimental Evidence [PDF]

Biomolecules
Rances Blanco, Blanco Rances
exaly   +2 more sources