Results 31 to 40 of about 1,938,563 (139)

Increased Concentration of Anti-Egg Albumin Antibodies in Cerebrospinal Fluid and Serum of Patients with Alzheimer’s Disease—Discussion on Human Serpins’ Similarity and Probable Involvement in the Disease Mechanism [PDF]

Biomolecules
Alzheimer’s Disease (AD) is a multifactorial process. Amyloid plaque formation constitutes the main characteristic of the disease. Despite the identification of numerous factors associated with AD, the mechanism remains unclear in several aspects ...
Dionysia Amanatidou, Magdalini Tsolaki, Vasileios Fouskas, Ioannis Gavriilidis, Maria Myriouni, Anna Anastasiou, Efthimia Papageorgiou, Diona Porfyriadou, Zoi Parcharidi, Eleftheria Papasavva, Maria Fili, Phaedra Eleftheriou   +11 more
doaj   +2 more sources

Anti-gal and anti-neu5gc responses in non-immunosuppressed patients following treatment with anti-thymocyte globulin

, 2017
Background Polyclonal antihuman thymocyte rabbit IgGs (antithymocyte globulin [ATG]) are popular immunosuppressive drugs used to prevent or treat organ or bone-marrow allograft rejection, graft versus host disease, and autoimmune diseases. However, animal-derived glycoproteins are also strongly immunogenic and rabbit ATG induces serum sickness disease ...
Salama, Apolline, Evanno, Gwénaëlle, Lim, Noha, Rousselot, Juliette, Le Berre, Ludmilla, Nicot, Arnaud, Bach, Jean-Marie, Brouard, Sophie, Harris, Kristina M., Ehlers, Mario R., Gitelman, Stephen E., Soulillou, Jean-Paul   +11 more
core   +4 more sources

Prevalence of anti-Neu5Gc antibodies in patients with hypothyroidism. [PDF]

Biomed Res Int, 2014
Background. N-Glycolylneuraminic acid (Neu5Gc) is a sialic acid synthesized by animals, but not by humans or birds. However, it can be incorporated in human cells and can trigger immune response. In the present study, we detected anti-Neu5Gc antibodies in samples of the general population and of patients suffering from hypothyroidism/Hashimoto’s ...
Eleftheriou P, Kynigopoulos S, Giovou A, Mazmanidi A, Yovos J, Skepastianos P, Vagdatli E, Petrou C, Papara D, Efterpiou M.   +9 more
europepmc   +4 more sources

Anti-Neu5Gc Antibodies do not Affect Response to Human or Chimeric Monoclonal Anti-CD20 Antibodies in Children with Nephrotic Syndrome. [PDF]

J Am Soc Nephrol, 2022
Angeletti A, Bruschi M, Kajana X, Lugani F, Candiano G, Ghiggeri GM.   +5 more
europepmc   +3 more sources

Erratum: At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody. [PDF]

Sci Rep, 2017
Scientific Reports 6: Article number: 20029; published online: 29 January 2016; updated: 30 June 2017. The original HTML version of this Article listed an incorrect volume number. This has now been corrected in the HTML version; the PDF version was correct at the time of publication.
Yu C, Gao K, Zhu L, Wang W, Wang L, Zhang F, Liu C, Li M, Wormald MR, Rudd PM, Wang J.   +10 more
europepmc   +4 more sources

Increased IGM and IGG anti-NEU5GC antibodies in infectious mononucleosis (IMN): link with multiple sclerosis (MS)?

, 2015
Introduction: Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating disease which displays an autoimmune component at its overt clinical stage. Among etiological hypotheses, the potential initiating role of EBV in the disease has been raised following works linking EBNA levels and the risk of MS occurrence [1] showing a linkage between ...
Le Berre, Ludmilla, Salama, Apolline, Evanno, Gwénaëlle, Rousse, Juliette, Nicot, Arnaud, Semana, Gilbert, Laplaud, David A., Imbert, Berthe-Marie, Drouet, Emmanuel, Soulillou, Jean-Paul   +9 more
core   +3 more sources

An Overview of the Importance and Value of Porcine Species in Sialic Acid Research

Biology, 2022
Humans frequently interact with pigs, whose meat is also one of the primary sources of animal protein. They are one of the main species at the center of sialic acid (Sia) research.
Oluwamayowa Joshua Ogun, Georg Thaller, Doreen Becker   +2 more
doaj   +1 more source

Absorption and Transport Mechanism of Red Meat-Derived N-glycolylneuraminic Acid and Its Damage to Intestinal Barrier Function through the NF-κB Signaling Pathway

Toxins, 2023
N-glycolylneuraminic acid (Neu5Gc) is a specific factor in red meat that induces intestinal disease. Our aim was to investigate the effect of Neu5Gc on the intestinal barrier as well as its mechanism of endocytosis and exocytosis. Ten specific inhibitors
Enqi He, Wei Quan, Jie Luo, Chuxin Liu, Wanting Zheng, Qingwu Shen   +5 more
doaj   +1 more source

Human Natural Antibodies to Mammalian Carbohydrate Antigens as Unsung Heroes Protecting against Past, Present, and Future Viral Infections

Antibodies, 2020
Human natural antibodies to mammalian carbohydrate antigens (MCA) bind to carbohydrate-antigens synthesized in other mammalian species and protect against zoonotic virus infections.
Uri Galili
doaj   +1 more source

Molecular Structural Analysis of Porcine CMAH–Native Ligand Complex and High Throughput Virtual Screening to Identify Novel Inhibitors

Pathogens, 2023
Porcine meat is the most consumed red meat worldwide. Pigs are also vital tools in biological and medical research. However, xenoreactivity between porcine’s N-glycolylneuraminic acid (Neu5Gc) and human anti-Neu5Gc antibodies poses a significant ...
Oluwamayowa Joshua Ogun, Georg Thaller, Doreen Becker   +2 more
doaj   +1 more source