Results 51 to 60 of about 1,938,563 (139)

Differential Recognition of Diet-Derived Neu5Gc-Neoantigens on Glycan Microarrays by Carbohydrate-Specific Pooled Human IgG and IgA Antibodies [PDF]

, 2019
Sialic acids (Sias) cover vertebrate cell surface glycans. N-Acetylneuraminic acid (Neu5Ac) and its hydroxylated form N-glycolylneuraminic acid (Neu5Gc) are common Sia in mammals.
Chen, Xi, Christoph Schneider, Vered Padler-Karavani (375363), Hai Yu, Vered Padler-Karavani, Schneider, Christoph, Xi Chen, Stephan von Gunten, Xi Chen (35903), Leviatan Ben-Arye, Shani, Yu, Hai, Salam Bashir, Shani Leviatan Ben-Arye, Bashir, Salam, Hai Yu (366836), Stephan von Gunten (340797), Shani Leviatan Ben-Arye (6440699), Ben-Arye, Shani Leviatan, Christoph Schneider (413360), Salam Bashir (6631076), von Gunten, Stephan, Padler-Karavani, Vered   +21 more
core   +3 more sources

Salmonid polysialyltransferases to generate a variety of sialic acid polymers

Scientific Reports, 2023
The human polysialyltransferases ST8Sia II and ST8Sia IV catalyze the transfer of several Neu5Ac residues onto glycoproteins forming homopolymers with essential roles during different physiological processes.
Mathieu Decloquement, Marzia Tindara Venuto, Virginie Cogez, Anna Steinmetz, Céline Schulz, Cédric Lion, Maxence Noel, Vincent Rigolot, Roxana Elin Teppa, Christophe Biot, Alexander Rebl, Sebastian Peter Galuska, Anne Harduin-Lepers   +12 more
doaj   +1 more source

A simple method to detect overall human anti-Neu5Gc reactivity.

, 2013
A. Human antibodies can bind to mouse glycoproteins from WT (Neu5Gc-positive) or Cmah-KO (Neu5Gc-deficient) mice revealing anti-Neu5Gc and/or general anti-mouse reactivity. B.
Hai Yu (366836), Jane C. Burns (268128), Vered Padler-Karavani (375363), Adriana H. Tremoulet (387274), Ajit Varki (375367), Xi Chen (35903)   +5 more
core   +1 more source

Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N-Acetylneuraminic Acid as a Host Adaptation

mBio, 2019
Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative bacterial pathogen that is adapted exclusively to human hosts. NTHi utilizes sialic acid from the host as a carbon source and as a terminal sugar on the outer membrane glycolipid ...
Preston S. K. Ng, Christopher J. Day, John M. Atack, Lauren E. Hartley-Tassell, Linda E. Winter, Tal Marshanski, Vered Padler-Karavani, Ajit Varki, Stephen J. Barenkamp, Michael A. Apicella, Michael P. Jennings   +10 more
doaj   +1 more source

Anti-Neu5Gc Antibody Kit Protocol - ELISA v3 [PDF]

, 2018
This protocol is essentially the same as a standard ELISA protocol, with one major exception - all animal compounds must be avoided in buffers, etc. because they contain Neu5Gc, which will interfere with antibody activity and result in misleading data.
openaire   +1 more source

Characterization of immunogenic Neu5Gc in bioprosthetic heart valves [PDF]

, 2018
Background: The two common sialic acids (Sias) in mammals are N-acetylneuraminic acid (Neu5Ac) and its hydroxylated form N-glycolylneuraminic acid (Neu5Gc). Unlike most mammals, humans cannot synthesize Neu5Gc that is considered foreign and recognized by
Cozzi, Emanuele, Chen, Xi, Fellah-Hebia, Imen, Galinanes, Manuel, Moshe Reuven, Eliran, Marshanski, Tal, Máñez Mendiluce, Rafael, Costa Vallés, Cristina, Leviatan Ben-Arye, Shani, Yu, Hai, Roussel, Jean-Christian, Soulillou, Jean-Paul, Breimer, Michael E., Tourneau, Thierry Le, Padler-Karavani, Vered   +14 more
core   +3 more sources

Anti-Neu5Gc Antibody Kit Protocol - ELISA v4 [PDF]

, 2019
This protocol is essentially the same as a standard ELISA protocol, with one major exception - all animal compounds must be avoided in buffers, etc. because they contain Neu5Gc, which will interfere with antibody activity and result in misleading data.
openaire   +1 more source

Poor Patient and Graft Outcome After Induction Treatment by Antithymocyte Globulin in Recipients of a Kidney Graft After Nonrenal Organ Transplantation

Transplantation Direct, 2018
Background. End-stage renal failure occurs in a substantial number of patients having received a nonrenal transplantation (NRT), for whom a kidney transplantation is needed.
Hoa Le Mai, PhD, Michèle Treilhaud, MD, Shani Leviatan Ben-Arye, PhD, Hai Yu, PhD, Hélène Perreault, PhD, Evelyn Ang, PhD, Katy Trébern-Launay, PhD, Julie Laurent, PhD, Stéphanie Malard-Castagnet, PhD, Anne Cesbron, MD, Thi Van Ha Nguyen, PhD, Sophie Brouard, PhD, Lionel Rostaing, MD, Pauline Houssel-Debry, MD, Christophe Legendre, MD, Sophie Girerd, MD, Michèle Kessler, MD, Emmanuel Morelon, MD, Antoine Sicard, MD, Valérie Garrigue, MD, Georges Karam, MD, Xi Chen, PhD, Magali Giral, MD, Vered Padler-Karavani, PhD, Jean Paul Soulillou, MD   +24 more
doaj   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, EarlyView.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source