Results 71 to 80 of about 1,938,563 (139)
Beyond Starch: Towards a Scalable Potato Platform for Molecular Farming
Plant Biotechnology Journal, Volume 24, Issue 7, Page 4619-4639, July 2026.Re‐engineering potato as a biosafe and host‐optimised platform for plant molecular farming by integrating intrinsic biological traits with targeted engineering strategies. ABSTRACT Thirty‐five years after the first recombinant protein was produced in potato and 30 years after clinical trials of edible vaccines from its tubers, the crop is being ...
Izabela Anna Chincinska +2 more
wiley +1 more source
Xenotransplantation, Volume 33, Issue 4, July/August 2026.ABSTRACT Xenotransplantation has entered a phase of accelerated clinical translation, necessitating renewed international consensus on governance, ethics, safety, and regulatory oversight. In September 2025, the International Xenotransplantation Association (IXA), in partnership with The Transplantation Society (TTS) and with engagement from the World ...
Wayne J. Hawthorne +25 more
wiley +1 more source
Distribution of Anti-Neu5Gc IgG titers in EPIC-Norfolk cohort using defined ELISA target antigens.
, 2018 Each dot represents a value for a single subject. (A) Levels of serum anti-Neu5Gc IgG quantified by ELISA using Neu5Gcα2-polyacrylamide (Neu5Gcα2-PAA) as the target antigen (N = 2716). The mean anti-Neu5Gc IgG titer was 8.6 μg/ml (SD±10.6). (B) Levels of
Annie N. Samraj (5410286) +15 more
core +1 more source
Xenotransplantation Literature Update: January–June 2026
Xenotransplantation, Volume 33, Issue 4, July/August 2026.ABSTRACT In the first half of 2026, xenotransplantation advanced through refinement rather than dramatic new clinical milestones. Clinical studies described graft physiology, immune infiltration, complement activation, coagulation incompatibility, and early function in living recipients, decedent models, and clinical islet xenotransplantation ...
Kasra Shirini +3 more
wiley +1 more source
Dietary Neu5Ac Intervention Protects Against Atherosclerosis Associated with Human-Like Neu5Gc loss [PDF]
, 2021 OBJECTIVE: Species-specific pseudogenization of the CMAH gene during human evolution eliminated common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) biosynthesis from its precursor, N-acetylneuraminic acid (Neu5Ac).
Gordts, Philip LSM +10 more
core +1 more source
Current Status of Kidney Xenotransplantation in Basic Research
Organ Medicine, Volume 3, Issue 2, Page 87-101, June 2026.Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley +1 more source
Correlation between total and inhibitable anti-Neu5Gc IgG titers in the NHS cohort.
, 2018 Plasma anti-Neu5Gc IgG levels were quantified by ELISA using wild type mouse serum that contains naturally occurring Neu5Gc-containing epitopes as the target antigen (N = 46).
Annie N. Samraj (5410286) +15 more
core +1 more source
One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy
Advanced Science, Volume 13, Issue 26, 8 May 2026.This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu +8 more
wiley +1 more source
Xenotransplantation, Volume 33, Issue 3, May/June 2026.ABSTRACT Objectives This study aimed to investigate the functional recovery of an 8‐gene‐edited pig heart after orthotopic xenotransplantation, the characteristics of the recipient's immune responses, and the efficacy of postoperative complication management to provide comprehensive experimental evidence for the clinical translation of xenogeneic ...
Xianzhi Wang +17 more
wiley +1 more source
Perinatal Gut Dysbiosis Reduces Milk Oligosaccharides via LPS‐Mediated Gut–Mammary Signaling in Mice
Food Frontiers, Volume 7, Issue 2, March 2026.Maternal gut dysbiosis elevates Gram‐negative bacterial lipopolysaccharide (LPS), which enters circulation and accumulates in mammary tissue. This compromises the blood–milk barrier and suppresses key enzymatic genes, ultimately reducing milk oligosaccharide synthesis and potentially affecting neonatal gut microbiota through breastfeeding.
Man‐Lin Zhou +9 more
wiley +1 more source