Results 81 to 90 of about 1,938,563 (139)

Expression of Human Thrombomodulin Prevents Early Thrombocytopenia and Thrombotic Microangiopathy in Pig‐to‐Nonhuman Primate Orthotopic Liver Xenotransplantation

open access: yesXenotransplantation, Volume 33, Issue 2, March/April 2026.
ABSTRACT Background Severe thrombocytopenia and coagulation dysregulation remain major barriers to survival in pig‐to‐primate liver xenotransplantation models. Methods Porcine livers with five genetic modifications (GTKO, CMAHKO, β4GalNT2KO, hCD55, and hTBM) were orthotopically transplanted into four Tibetan macaques under two conventional ...
Zhongqiang Zhang   +17 more
wiley   +1 more source

Distribution of Anti-Neu5Gc IgG titers against a mixture of epitopes in the EPIC-Norfolk cohort.

open access: yes, 2018
(A) Serum anti-Neu5Gc IgG antibodies in the EPIC-Norfolk population assayed as in Fig 1. Serum total and inhibitable anti-Neu5Gc IgG levels were quantified by ELISA using wild type mouse serum that contains naturally occurring Neu5Gc containing epitopes ...
Annie N. Samraj (5410286)   +15 more
core   +1 more source

Donor‐Derived Cell‐Free DNA (dd‐cfDNA) as an Early Noninvasive Biomarker of Graft Injury in Pig‐to‐Monkey Islet Xenotransplantation

open access: yesXenotransplantation, Volume 33, Issue 2, March/April 2026.
ABSTRACT Background In pig‐to‐nonhuman primate islet transplantation, reliable, sensitive biomarkers are needed to detect graft damage at an early stage before irreversible islet loss occurs. In our study, we investigated donor‐derived cell‐free DNA (dd‐cfDNA) as an early, noninvasive biomarker of graft injury by analyzing its correlation with porcine ...
Ji‐Jing Yan   +10 more
wiley   +1 more source

Changes in the Serum and Tissue Levels of Free and Conjugated Sialic Acids, Neu5Ac, Neu5Gc, and KDN in Mice after the Oral Administration of Edible Bird’s Nests: An LC–MS/MS Quantitative Analysis

open access: yesSeparations
Edible bird’s nests have a variety of biological activities, the main components of which are sialic acids. Sialic acids are a group of nine-carbon N-acetylated derivatives of neuraminic acid containing a keto group at position C2 and play important ...
Meng-Hua Wang   +5 more
doaj   +1 more source

Buffalo meat quality, processing, and marketing: harnessing its benefits and nutraceutical potential

open access: yesRevista Científica, 2023
Buffalo meat production is growing in different countries also because buffalo products exhibit some positive characteristics for human health compared to red meats from other species. However, meat quality is also defined by organoleptic aspects.
Sebastiana Failla
doaj  

Antibody‐Targeted Artificial T Cell and Natural Killer Cell Derived Vesicles for Cancer Immunotherapy

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
ABSTRACT T cell and NK92 cell‐derived extracellular vesicles or artificial cell‐derived vesicles (ACDVs) exhibit anti‐cancer effects through inherited cytotoxic proteins like perforin and granzyme or transmembrane receptors like FasL and TRAIL. The anti‐cancer potential of artificial T and NK vesicles has been improved by attaching targeting moieties ...
Brijesh Parlekar   +7 more
wiley   +1 more source

Lack of Correlation between Anti-Neu5Gc IgG titers and red meat intake in the NHS II population.

open access: yes, 2018
Plasma anti-Neu5Gc IgG levels (total anti-Neu5Gc IgG levels, or inhibitable anti-Neu5Gc IgG levels) were quantified by ELISA using wild type mouse serum as a target that contains multiple naturally occurring Neu5Gc containing epitopes (N = 338 ...
Annie N. Samraj (5410286)   +15 more
core   +1 more source

Evaluation of primate anti-pig xenoreactive immune responses using immortalized aortic endothelial cells from genetically modified pigs

open access: yesFrontiers in Immunology
Porcine vascular endothelial cells are primary targets of humoral and cellular immune responses in pig-to-primate organ xenotransplantation. Although porcine aortic endothelial cells (PAECs) are widely used to evaluate primate anti-pig immune responses ...
Man Zhang   +34 more
doaj   +1 more source

Specific detection of anti-Neu5Gc IgG in normal human serum.

open access: yes, 2013
A. Plates were coated with WT or Cmah-KO mouse sera and Anti-Neu5Gc IgG of human serum S34 [16] tested by ELISA. B. Plates were coated with WT or Cmah-KO mouse sera, then human serum S34 IgG binding tested by ELISA (0) or by EIA after pre-incubation of ...
Hai Yu (366836)   +5 more
core   +1 more source

Antitumor effects of the GM3(Neu5Gc) ganglioside-specific humanized antibody 14F7hT against Cmah-transfected cancer cells. [PDF]

open access: yes, 2019
The GM3(Neu5Gc) ganglioside represents a tumor-specific antigen that is considered a promising target for cancer immunotherapy. We previously demonstrated that the humanized antibody 14F7hT, specific for this ganglioside, exhibited significant antitumor ...
Simon, Hans-Uwe   +9 more
core   +2 more sources

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