Dietary linoleic acid-induced alterations in pro- and anti-nociceptive lipid autacoids [PDF]
Molecular Pain, 2016 Background Chronic idiopathic pain syndromes are major causes of personal suffering, disability, and societal expense. Dietary n-6 linoleic acid has increased markedly in modern industrialized populations over the past century.
Christopher E Ramsden MD +11 more
doaj +2 more sources
Peripheral Anti-nociceptive and Anti-inflammatory Effect of OleanoliAcid in a Rat Model of Osteoarthritis [PDF]
, 2021 Background: Oleanolic acid (OA) is a naturally occurring pentacyclic triterpenoid with multifarious actions. The anti-inflammatory effect it exerts when taken orally is the most important; however, the underpinning mechanisms of such effects have not yet
Fouani, Malak +3 more
core +1 more source
A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?
İstanbul Journal of Pharmacy, 2022 Pain is sensed by the activation of painful nociceptors in the periphery or by pain mediators, such as bradykinin, serotonin, histamine, and prostaglandin, released from the damaged tissue, afferent transmission to the medulla spinalis, and by trans- mission stages to the high centers over the dorsal horn. Pain, which was seen as only a warning sign in
EKEN, Hazal +2 more
openaire +4 more sources
Abuse Liability, Anti-Nociceptive, and Discriminative Stimulus Properties of IBNtxA. [PDF]
ACS Pharmacol Transl Sci, 2020 Abuse Liability, Anti-Nociceptive, and Discriminative Stimulus Properties of ...
Islam A +14 more
europepmc +2 more sources
Anti‐nociceptive effects of oxytocin receptor modulation in healthy volunteers–A randomized, double‐blinded, placebo‐controlled study [PDF]
, 2021 Background: There is increasing evidence for oxytocin as a neurotransmitter in spinal nociceptive processes. Hypothalamic oxytocinergic neurons project to the spinal dorsal horn, where they activate GABA-ergic inhibitory interneurons.
Arendt-Nielsen, Lars +21 more
core +2 more sources
Anti-Nociceptive And Anti-Inflammatory Effects Of A Nigerian Polyherbal Tonic Tea (PHT) Extract In Rodents [PDF]
, 2008 The study investigated the anti-nociceptive and anti-inflammatory properties of a Nigerian Polyherbal Health Tonic tea aqueous extract (PHT) in rodents of both sexes. 100 - 500 mg kg–1 of the aqueous extract was administered via the intra-peritoneal (i.p.
AT Isaac +5 more
core +3 more sources
Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]
, 2007 Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Geisslinger, Gerd +17 more
core +1 more source
Dopamine-neurotransmission and nociception in zebrafish: An anti-nociceptive role of dopamine receptor drd2a [PDF]
, 2021 Dopamine (DA) is an important modulator in nociception and analgesia. Spinal DA receptors are involved in descending modulation of the nociceptive transmission.
Eijkenboom, I. +11 more
core +1 more source
Fine-grained nociceptive maps in primary somatosensory cortex [PDF]
, 2012 Topographic maps of the receptive surface are a fundamental feature of neural organization in many sensory systems. While touch is finely mapped in the cerebral cortex, it remains controversial how precise any cortical nociceptive map may be.
Longo, Matthew R. +10 more
core +1 more source
The cytotoxicity, anti-inflammation, anti-nociceptive and oral ulcer healing properties of coconut shell liquid smoke [PDF]
, 2021 Introduction: Coconut shell liquid smoke (CS-LS) from Cocos nucifera L. has been traditionally used by Indonesians as a natural preservative. Besides that, liquid smoke is also used as a medicine to treat various types of wounds.
Diah Savitri Ernawati, - +17 more
core +2 more sources