Results 1 to 10 of about 561,822 (204)

Isolation of a Novel Flavanonol and an Alkylresorcinol with Highly Potent Anti-Trypanosomal Activity from Libyan propolis [PDF]

Molecules, 2019
Twelve propolis samples from different parts of Libya were investigated for their phytochemical constituents. Ethanol extracts of the samples and some purified compounds were tested against Trypanosoma brucei, Plasmodium falciparum and against two ...
Weam Siheri, Godwin U. Ebiloma, John O. Igoli, Alexander I. Gray, Marco Biddau, Pilaslak Akrachalanont, Samya Alenezi, Mohammad A. Alwashih, RuAngelie Edrada-Ebel, Sylke Muller, Catherine E. Lawrence, James Fearnley, David G. Watson, Harry P. De Koning   +13 more
doaj   +5 more sources

Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges. [PDF]

PLoS ONE, 2015
Marine sponge-associated actinomycetes are considered as promising sources for the discovery of novel biologically active compounds. In the present study, a total of 64 actinomycetes were isolated from 12 different marine sponge species that had been ...
Cheng Cheng, Lynsey MacIntyre, Usama Ramadan Abdelmohsen, Hannes Horn, Paraskevi N Polymenakou, RuAngelie Edrada-Ebel, Ute Hentschel   +6 more
doaj   +15 more sources

Evaluation of the Anti-Trypanosomal Activity of Vietnamese Essential Oils, with Emphasis on Curcuma longa L. and Its Components [PDF]

Molecules, 2019
Human African trypanosomiasis (HAT), known as sleeping sickness and caused by Trypanosoma brucei, is threatening low-income populations in sub-Saharan African countries with 61 million people at risk of infection.
Thanh Binh Le, Claire Beaufay, Duc Trong Nghiem, Tuan Anh Pham, Marie-Paule Mingeot-Leclercq, Joëlle Quetin-Leclercq   +5 more
doaj   +5 more sources

Anti-Trypanosomal Activity of Nigerian Plants and Their Constituents [PDF]

Molecules, 2015
African trypanosomiasis is a vector-borne parasitic disease causing serious risks to the lives of about 60 million people and 48 million cattle globally.
Ngozi Justina Nwodo, Akachukwu Ibezim, Fidele Ntie-Kang, Michael Umale Adikwu, Chika John Mbah   +4 more
doaj   +5 more sources

Novel flavanones with anti-trypanosomal activity isolated from Zambian and Tanzanian propolis samples [PDF]

International Journal for Parasitology: Drugs and Drug Resistance, 2020
A bioassay-guided phytochemical investigation of propolis samples from Tanzania and Zambia that screened for activity against Trypanosoma brucei has led to the isolation of two novel flavanones with promising antitrypanosomal activity. The compounds were
Samya S. Alenezi, Manal J. Natto, John O. Igoli, Alexander I. Gray, James Fearnley, Hugo Fearnley, Harry P. de Koning, David G. Watson   +7 more
doaj   +4 more sources

KBE009: A Bestatin-Like Inhibitor of the Trypanosoma cruzi Acidic M17 Aminopeptidase with In Vitro Anti-Trypanosomal Activity. [PDF]

Life (Basel), 2021
Chagas disease, caused by the kinetoplastid parasite Trypanosoma cruzi, is a human tropical illness mainly present in Latin America. The therapies available against this disease are far from ideal. Proteases from pathogenic protozoan have been considered
González-Bacerio J, Arocha I, Aguado ME, Méndez Y, Marsiccobetre S, Izquierdo M, Rivera DG, Figarella K, Uzcátegui NL.   +8 more
europepmc   +4 more sources

Anti-trypanosomal activity and DNA fingerprinting of fifteen Euphorbia species using ISSR and SCoT markers [PDF]

Beni-Suef University Journal of Basic and Applied Sciences, 2021
Background Euphorbia is the largest genus in family Euphorbiaceae with a great biological and genetic diversity. The anti-trypanosomal activity of the crude extract of 15 Euphorbia species against Trypanosoma brucei brucei was carried out.
Seham S. El-Hawary, Nadia M. Lithy, Elham Amin, Sameh F. AbouZid, Rabab Mohammed   +4 more
doaj   +3 more sources

Synthesis, Structure and In Vitro Anti-Trypanosomal Activity of Non-Toxic Arylpyrrole-Based Chalcone Derivatives [PDF]

Molecules, 2020
With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in moderate to good yields.
Ayanda I. Zulu, Ogunyemi O. Oderinlo, Cuan Kruger, Michelle Isaacs, Heinrich C. Hoppe, Vincent J. Smith, Clinton G. L. Veale, Setshaba D. Khanye   +7 more
doaj   +3 more sources

Anti-trypanosomal Activity of Bufonidae (Toad) Venom Crude Extract on Trypanosoma brucei brucei in Swiss Mice [PDF]

Journal of Zoological Research, 2022
Trypanosomiasis afflicts about 6 ~ 7 million people globally and to a large extent impedes livestock production in Africa. Naturally, trypanosomal parasites undergo genetic mutation and have developed resistance over a wide range of therapies.
A., Adejoh V., A., Aliyu A., A., Ashigar M., A., Odey S., A., Ombugadu, A., Pam V., E., Anyebe G., F., Ameh S., I., Maikenti J., J., Ajah L., J., Ezeobi A., J., Omalu I. C., O., Ahmed H., O., Aimankhu P., O., Ayim J., O., Ayuba S., R., Uzoigwe N., S., Attah A., S., Daramola O., S., Kure M., S., Tanko N.   +20 more
core   +4 more sources

Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors. [PDF]

PLoS Neglected Tropical Diseases, 2017
The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. Anti-trypanosomal activity against the CL Brener strain of T. cruzi was observed in the 0.1 μM to 1 μM range for three
Antonio C B Burtoloso, Sérgio de Albuquerque, Mark Furber, Juliana C Gomes, Cristiana Gonçalez, Peter W Kenny, Andrei Leitão, Carlos A Montanari, José Carlos Quilles, Jean F R Ribeiro, Josmar R Rocha   +10 more
doaj   +3 more sources