In Vivo anti-trypanosomal activity of dichloromethane and methanol crude leaf extracts of Dovyalis abyssinica (Salicaceae) against Trypanosoma congolense. [PDF]
BMC Complement Altern Med, 2015 BackgroundAfrican trypanosomiasis affects both humans and livestock in sub-Saharan countries including Ethiopia. Due to limitations to current chemotherapy, there is an urgent need for the development of new, safe, cheap and effective drugs.
Tadesse B +3 more
europepmc +4 more sources
Anti-trypanosomal activity of doubly modified salinomycin derivatives [PDF]
European Journal of Medicinal Chemistry, 2019 As a group of biologically active compounds, polyether antibiotics (ionophores) show a broad spectrum of interesting pharmacological properties, ranging from anti-bacterial to anti-cancer activities. There is increasing evidence that ionophores, including salinomycin (SAL), and their semi-synthetic analogues are promising candidates for the development
Michał Antoszczak +4 more
semanticscholar +6 more sources
Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae) Atividade anti-tripanosomicida de triterpenes pentacíclicos isolados de Austroplenckia populnea (Celastraceae) [PDF]
Revista do Instituto de Medicina Tropical de São Paulo, 2002 Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20alpha-hydroxy-tingenone showed high activity, epikatonic acid was less ...
Lucienir Pains DUARTE +4 more
doaj +7 more sources
KBE009: A Bestatin-Like Inhibitor of the Trypanosoma cruzi Acidic M17 Aminopeptidase with In Vitro Anti-Trypanosomal Activity. [PDF]
Life (Basel), 2021 Chagas disease, caused by the kinetoplastid parasite Trypanosoma cruzi, is a human tropical illness mainly present in Latin America. The therapies available against this disease are far from ideal. Proteases from pathogenic protozoan have been considered
González-Bacerio J +8 more
europepmc +2 more sources
In vitro anti‐trypanosomal activity of synthetic nitrofurantoin‐triazole hybrids against Trypanosoma species causing human African trypanosomosis [PDF]
Fundamental & Clinical Pharmacology, 2023 Human African trypanosomosis (HAT) which is also known as sleeping sickness is caused by Trypanosoma brucei gambiense that is endemic in western and central Africa and T. b. rhodesiense that is endemic in eastern and southern Africa.
Anna Seetsi +5 more
openalex +2 more sources
DNA fingerprinting of five Tabebuia species with reference to their anti-trypanosomal activity [PDF]
Pharmaceutical Sciences Asia, 2022 Tabebuia is the largest genus of the Bignoniaceae family, with great importance due to its beautiful decorative flowering trees, as well as, its remarkable biological activities.
Seham El-Hawary +6 more
doaj +2 more sources
Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 Amidinobenzimidazole derivatives connected to 1-aryl-substituted 1,2,3-triazole through phenoxymethylene linkers 7a–7e, 8a–8e, and 9a–9e were designed and synthesised with the aim of evaluating their anti-bacterial and anti-trypanosomal activities and ...
Andrea Bistrović +8 more
doaj +3 more sources
High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. [PDF]
Bioorg Med Chem Lett, 2007 Trypanothione reductase (TR), an enzyme that buffers oxidative stress in trypanosomatid parasites, was screened against commercial libraries containing approximately 134,500 compounds. After secondary screening, four chemotypes were identified as screening positives with selectivity for TR over human glutathione reductase. Thirteen compounds from these
Martyn DC +3 more
europepmc +6 more sources
Anti-trypanosomal activity of 1,2,3,4,6-penta-O-galloyl-β -D-glucose isolated from Plectranthus barbatus Andrews (Lamiaceae) [PDF]
Química Nova, 2012 MeOH extract from the leaves of Plectranthus barbatus Andrews (Lamiaceae), showed in vitro anti-trypanosomal activity. The bioassay-guided fractionation resulted in the isolation of a gallic acid derivative, identified as 1,2,3,4,6-penta-O-galloyl-β-D ...
Roberta T. dos Santos +5 more
doaj +2 more sources
Arid-zone Journal of Basic & Applied Research, 2022 In sub-Saharan Africa, trypanosomosis is a constraint on livestock production. Thus, it is imperative to develop alternative strategies since current chemotherapy is bedevilled by high cost and limited access.
Wasagwa John +4 more
openalex +2 more sources