Results 31 to 40 of about 561,822 (204)

Eugenia uniflora and Syzygium samarangense extracts exhibit anti-trypanosomal activity: Evidence from in-silico molecular modelling, in vitro, and in vivo studies

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021
Mohamed S. Attia, Mohammed Auwal Ibrahim, Hadiza Abdullahi, Raphael Aminu, Saad Bello Saad, Sonja Krstin, Michaël Wink, Mansour Sobeh   +7 more
openalex   +2 more sources

In vitro anti-trypanosomal activity of crude extract and fractions of Trichoscypha acuminata stem bark, Spathodea campanulata flowers, and Ficus elastica lianas on Trypanosoma brucei brucei

AIMS Molecular Science
The low therapeutic index of available trypanocidal drugs and the increasing emergence of resistant Trypanosoma parasites indicate the urgent need to develop new strategies for trypanosomiasis control.
Jean Emmanuel Mbosso Teinkela, Philippe Belle Ebanda Kedi , Jean Baptiste Hzounda Fokou, Michelle Isaacs, Lisette Pulchérie Yoyo Ngando, Gaelle Wea Tchepnou, Hassan Oumarou, Xavier Siwe Noundou   +7 more
doaj   +2 more sources

<i>In vitro</i> anti-trypanosomal activity of <i>Bitis arietans</i> crude venom against <i>Trypanosoma brucei brucei</i>

, 2019
African Animal trypanosomosis (AAT) otherwise known as Nagana is a resurgent disease in Africa. It is caused by Trypanosoma brucei brucei , Trypanosoma congolense , Trypanosoma vivax , Trypanosoma evansi a mong others.
Gloria Dada Chechet, G. Peter
openalex   +3 more sources

Invivo Anti-Trypanosomal Activity of the Leaf Extracts of Albizia Schimperiana (Fabaceae) Against Trypanosoma Congolense Infection in Mice

, 2015
Objectives: The objective of this study was to evaluate effect of dichloromethane (DCM) and methanol (MeOH) extracts of the leaf of Albizia schimperiana against Trypanosoma congolense using in vivo mice models.
Workineh Shibeshi
openalex   +2 more sources

Chemoselective Synthesis and Anti-Kinetoplastidal Properties of 2,6-Diaryl-4H-tetrahydro-thiopyran-4-one S-Oxides: Their Interplay in a Cascade of Redox Reactions from Diarylideneacetones [PDF]

Molecules
2,6-Diaryl-4H-tetrahydro-thiopyran-4-ones and corresponding sulfoxide and sulfone derivatives were designed to lower the major toxicity of their parent anti-kinetoplatidal diarylideneacetones through a prodrug effect.
Thibault Gendron, Don Antoine Lanfranchi, Nicole I. Wenzel, Hripsimée Kessedjian, Beate Jannack, Louis Maes, Sandrine Cojean, Thomas J. J. Müller, Philippe M. Loiseau, Elisabeth Davioud-Charvet   +9 more
doaj   +2 more sources

High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. [PDF]

Bioorg Med Chem Lett, 2007
Martyn DC, Jones DC, Fairlamb AH, Clardy J.   +3 more
europepmc   +3 more sources

Digalloyl Glycoside: A Potential Inhibitor of Trypanosomal PFK from Euphorbia abyssinica J.F. Gmel

Plants, 2022
Human African trypanosomiasis is an endemic infectious disease caused by Trypanosoma brucei via the bite of tsetse-fly. Most of the drugs used for the treatment, e.g., Suramin, have shown several problems, including the high level of toxicity ...
Seham S. El-Hawary, Rabab Mohammed, Nadia M. Lithy, Sameh Fekry AbouZid, Mostafa A. Mansour, Suliman A. Almahmoud, Bader Huwaimel, Elham Amin   +7 more
doaj   +1 more source

Anti-trypanosomal activity of doubly modified salinomycin derivatives [PDF]

European journal of medicinal chemistry, 2019
Michał Antoszczak, Dietmar Steverding, Michał Sulik, Jan Janczak, Adam Huczyński   +4 more
openalex   +2 more sources

In Vitro Anti-Trypanosoma cruzi Activity of Halophytes from Southern Portugal Reloaded: A Special Focus on Sea Fennel (Crithmum maritimum L.)

Plants, 2021
Marine halophytes are an outstanding reservoir of natural products and several species have anti-infectious traditional uses. However, reports about their potential use against neglected tropical ailments, such as Chagas disease, are scarce.
Catarina G. Pereira, Carolina Borsoi Moraes, Caio H. Franco, Clarissa Feltrin, Raphaël Grougnet, Euzébio Guimarães Barbosa, Michele Panciera, Carlos Roque D. Correia, Maria João Rodrigues, Luísa Custódio   +9 more
doaj   +1 more source

The anti‐Trypanosoma activities of medicinal plants: A systematic review of the literature

Veterinary Medicine and Science, 2022
Background The existing drug treatments for trypanosomiases are limited and suffer from shortcomings due to their toxicity and the emergence of resistant parasites.
Shahin Nekoei, Faham Khamesipour, Solomon Habtemariam, Wanderley deSouza, Pardis Mohammadi Pour, Seyed Reza Hosseini   +5 more
doaj   +1 more source