Results 31 to 40 of about 581,138 (251)

CHARACTERIZATION AND ANTIPARASITIC ACTIVITY OF BENZOPHENONE THIOSEMICARBAZONES ON Trypanosoma brucei brucei [PDF]

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2011
The structure of four synthesized thiosemicarbazones, substituted or not, of benzophenone has been confirmed by spectrometrical analysis IR, NMR 1H and 13C. Their anti-trypanosomal activities were evaluated on Trypanosoma brucei brucei.
Georges C. Accrombessi, Jacques Poupaert, Raymond H. Fatondji, Salomé D. S. Kpoviessi, Fernand A. Gbaguidi, Bienvenu Glinma   +5 more
doaj   +1 more source

Anti-trypanosomal Activity of Bufonidae (Toad) Venom Crude Extract on Trypanosoma brucei brucei in Swiss Mice [PDF]

Journal of Zoological Research, 2022
Trypanosomiasis afflicts about 6 ~ 7 million people globally and to a large extent impedes livestock production in Africa. Naturally, trypanosomal parasites undergo genetic mutation and have developed resistance over a wide range of therapies.
A., Adejoh V., A., Aliyu A., A., Ashigar M., A., Odey S., A., Ombugadu, A., Pam V., E., Anyebe G., F., Ameh S., I., Maikenti J., J., Ajah L., J., Ezeobi A., J., Omalu I. C., O., Ahmed H., O., Aimankhu P., O., Ayim J., O., Ayuba S., R., Uzoigwe N., S., Attah A., S., Daramola O., S., Kure M., S., Tanko N.   +20 more
core   +3 more sources

In vitro Anti-trypanosomal Activity of Ethanolic and n-Hexane Extracts of Hymenocardia acida Stem Bark against Trypanosoma brucei brucei and Trypanosoma congolense

UMYU Journal of Microbiology Research
The development of resistance by trypanosomes to existing trypanocidal drugs necessitates the need to search for safer and more effective alternative drugs with a broad spectrum of activity.
Lawal, S. M., Inabo, H. I., Ella, E. E., Okubanjo, O. O.   +3 more
doaj   +3 more sources

Invivo Anti Trypanosomal Activity of Aqueous Extractof <i>Azadirachta indica</i> Leaves on <i>Trypanosoma brucei brucei</i> Infected Mice [PDF]

, 2018
Azadirachta indica commonly known as Neem is known to possess high medicinal value. This study aimed at determining the in vivo anti trypanosomal potential of aqueous extracts of A. indica leaves on Trypanosoma brucei brucei infected mice.
Okoh Martina Enyanwu
openalex   +2 more sources

Affinity is an important determinant of the anti-trypanosome activity of nanobodies.

PLoS Neglected Tropical Diseases, 2012
BackgroundThe discovery of Nanobodies (Nbs) with a direct toxic activity against African trypanosomes is a recent advancement towards a new strategy against these extracellular parasites.
Guy Caljon, Benoît Stijlemans, Dirk Saerens, Jan Van Den Abbeele, Serge Muyldermans, Stefan Magez, Patrick De Baetselier   +6 more
doaj   +4 more sources

Anti-Trypanosomal Bufadienolides from the Oocytes of the Toad Rhinella alata (Anura, Bufonidae) [PDF]

Molecules, 2023
Amphibians are widely known as a prolific source of bioactive metabolites. In this work, we isolated and characterized compounds with antiparasitic activity from the oocytes of the toad Rhinella alata collected in Panama.
Candelario Rodriguez, Roberto Ibáñez, Dionisio A. Olmedo, Michelle Ng, Carmenza Spadafora, Armando A. Durant-Archibold, Marcelino Gutiérrez   +6 more
doaj   +2 more sources

Toxicity study and anti-trypanosomal activities of aqueous and methanol whole plant extracts of Brillantaisia owariensis on Trypanosoma brucei-induced infection in BALB/c mice [PDF]

Clinical Phytoscience, 2021
Background The problem of drug resistance and toxicity in trypanosomiasis is ever-increasing, thereby creating a need to search for efficacious and safer alternatives that are of plant origin.
Nafisa Garba Ayawa, Suleiman Babatunde Ramon-Yusuf, Yunusa Adamu Wada, Sonnie Joshua Oniye, Dalhatu Mukhtari Shehu   +4 more
doaj   +2 more sources

Discovery of Trypanosoma brucei inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides [PDF]

Communications Chemistry
Sets of electrophilic probes are generally prepared using a narrow toolkit of robust reactions, which tends to limit both their structural and functional diversity.
Brian S. Mantilla, Jack S. White, William R. T. Mosedale, Andrew Gomm, Adam Nelson, Terry K. Smith, Megan H. Wright   +6 more
doaj   +2 more sources

Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense [PDF]

Molecules, 2017
In our continued search for natural compounds with activity against Trypanosoma brucei, causative agent of human African trypanosomiasis (HAT, “sleeping sickness”), we have investigated extracts from the leaves and bark of the West African Holarrhena ...
Charles Okeke Nnadi, Ngozi Justina Nwodo, Marcel Kaiser, Reto Brun, Thomas J. Schmidt   +4 more
doaj   +4 more sources

Anti-trypanosomal activity of crude and nano-conjugated ethanol stem bark extracts of Sterculia setigera in mice

Bayero Journal of Pure and Applied Sciences, 2021
This study was carried out to screen for anti-trypanosomal activities of Sterculia setigera crude and nano-conjugated ethanol extracts of synthesized gold nanoparticles (AuNPs). Fresh stem bark of S.
M.O. Abdulrazaq, H.Y. Adeyemi, Abdulrahman Abdulkareem, M.T. Bankole, Abubakar Ahmed   +4 more
openalex   +3 more sources